| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Palo Alto Investors LP | 1,491,500 | 17,779,000 | 24.37% | ||
| 2 | MPM ASSET MANAGEMENT LLC | 1,066,774 | 12,716,000 | 17.43% | ||
| 3 | Tekla Capital Management LLC | 970,495 | 9,833,000 | 13.48% | ||
| 4 | JPMORGAN CHASE & CO | 522,975 | 6,233,000 | 8.54% | ||
| 5 | PFM Health Sciences, LP | 385,110 | 4,591,000 | 6.29% | ||
| 6 | Visium Asset Management, LP | 367,175 | 4,377,000 | 6.00% | ||
| 7 | FARALLON CAPITAL MANAGEMENT LLC | 271,712 | 3,239,000 | 4.44% | ||
| 8 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 300,000 | 3,147,000 | 4.31% | ||
| 9 | BlackRock Fund Advisors | 173,276 | 2,065,000 | 2.83% | ||
| 10 | HighTower Advisors, LLC | 133,083 | 1,586,000 | 2.17% | ||
| 11 | VANGUARD GROUP INC | 100,842 | 1,202,000 | 1.65% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 86,601 | 1,032,000 | 1.41% | ||
| 13 | SHAKER INVESTMENTS LLC/OH | 71,000 | 846,000 | 1.16% | ||
| 14 | STATE STREET CORP | 40,235 | 480,000 | 0.66% | ||
| 15 | SAC Capital Advisors LP | 34,821 | 415,000 | 0.57% | ||
| 16 | GOLDMAN SACHS GROUP INC | 33,815 | 403,000 | 0.55% | ||
| 17 | Nationwide Fund Advisors | 31,246 | 372,000 | 0.51% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 25,778 | 307,000 | 0.42% | ||
| 19 | MORGAN STANLEY | 24,704 | 294,000 | 0.40% | ||
| 20 | NORTHERN TRUST CORP | 24,376 | 290,000 | 0.40% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 21,486 | 256,000 | 0.35% | ||
| 22 | SHEPHERD KAPLAN KROCHUK, LLC | 20,525 | 245,000 | 0.34% | ||
| 23 | TEACHERS ADVISORS, LLC | 15,310 | 182,000 | 0.25% | ||
| 24 | Partner Investment Management, L.P. | 15,222 | 181,000 | 0.25% | ||
| 25 | Baldwin Investment Management, LLC | 14,593 | 174,000 | 0.24% | SH | |
| 26 | Bank of New York Mellon Corp | 14,305 | 170,000 | 0.23% | ||
| 27 | BlackRock Investment Management, LLC | 14,218 | 169,000 | 0.23% | ||
| 28 | BANQUE PICTET & CIE SA | 12,945 | 154,000 | 0.21% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,500 | 137,000 | 0.19% | ||
| 30 | Tower Research Capital LLC (TRC) | 2,800 | 33,000 | 0.05% | ||
| 31 | DEUTSCHE BANK AG\ | 1,603 | 18,000 | 0.02% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 1,000 | 12,000 | 0.02% | ||
| 33 | BLACKROCK ADVISORS LLC | 941 | 11,000 | 0.02% | ||
| 34 | CITIGROUP INC | 166 | 2,000 | 0.00% | ||
| 35 | BARCLAYS PLC | 173 | 2,000 | 0.00% | ||
| 36 | UBS AG | 61 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
