| 1 |
HighTower Advisors, LLC |
1,950,184 |
31,242,000 |
24.49% |
|
|
| 2 |
Palo Alto Investors LP |
1,468,300 |
23,522,000 |
18.44% |
|
|
| 3 |
MPM ASSET MANAGEMENT LLC |
1,066,774 |
17,090,000 |
13.40% |
|
|
| 4 |
Tekla Capital Management LLC |
970,495 |
13,215,000 |
10.36% |
|
|
| 5 |
EAGLE ASSET MANAGEMENT INC |
476,589 |
7,634,000 |
5.98% |
|
|
| 6 |
PFM Health Sciences, LP |
397,516 |
6,368,000 |
4.99% |
|
|
| 7 |
Visium Asset Management, LP |
331,680 |
5,314,000 |
4.17% |
|
|
| 8 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
300,000 |
4,806,000 |
3.77% |
|
|
| 9 |
FARALLON CAPITAL MANAGEMENT LLC |
200,000 |
3,204,000 |
2.51% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
150,000 |
2,403,000 |
1.88% |
|
|
| 11 |
JPMORGAN CHASE & CO |
113,197 |
1,814,000 |
1.42% |
|
|
| 12 |
VANGUARD GROUP INC |
110,568 |
1,771,000 |
1.39% |
|
|
| 13 |
SHAKER INVESTMENTS LLC/OH |
71,000 |
1,137,000 |
0.89% |
|
|
| 14 |
NORTHERN TRUST CORP |
59,442 |
952,000 |
0.75% |
|
|
| 15 |
Bank of New York Mellon Corp |
54,843 |
879,000 |
0.69% |
|
|
| 16 |
AXA S.A. |
48,315 |
774,000 |
0.61% |
|
|
| 17 |
Rhenman & Partners Asset Management AB |
46,000 |
737,000 |
0.58% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
29,598 |
474,000 |
0.37% |
|
|
| 19 |
Paloma Partners Management Co |
27,119 |
434,000 |
0.34% |
|
|
| 20 |
BANK OF AMERICA CORP /DE/ |
25,519 |
409,000 |
0.32% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
21,438 |
343,000 |
0.27% |
|
|
| 22 |
BlackRock Fund Advisors |
19,157 |
307,000 |
0.24% |
|
|
| 23 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
18,091 |
290,000 |
0.23% |
|
|
| 24 |
SHEPHERD KAPLAN KROCHUK, LLC |
15,354 |
246,000 |
0.19% |
|
|
| 25 |
Partner Investment Management, L.P. |
15,222 |
244,000 |
0.19% |
|
|
| 26 |
BANQUE PICTET & CIE SA |
15,220 |
244,000 |
0.19% |
|
|
| 27 |
Baldwin Investment Management, LLC |
14,593 |
234,000 |
0.18% |
|
SH |
| 28 |
LMR Partners LLP |
13,691 |
219,000 |
0.17% |
|
|
| 29 |
GOLDMAN SACHS GROUP INC |
13,679 |
219,000 |
0.17% |
|
|
| 30 |
TFS CAPITAL LLC |
13,456 |
216,000 |
0.17% |
|
|
| 31 |
MILLENNIUM MANAGEMENT LLC |
12,166 |
195,000 |
0.15% |
|
|
| 32 |
CREDIT SUISSE AG/ |
11,262 |
180,000 |
0.14% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
9,274 |
148,000 |
0.12% |
|
|
| 34 |
BARCLAYS PLC |
7,564 |
121,000 |
0.09% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
5,318 |
85,000 |
0.07% |
|
|
| 36 |
MORGAN STANLEY |
2,363 |
38,000 |
0.03% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
1,000 |
16,000 |
0.01% |
|
|
| 38 |
BlackRock Investment Management, LLC |
1,022 |
16,000 |
0.01% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
501 |
8,000 |
0.01% |
|
|
| 40 |
BANK OF MONTREAL /CAN/ |
170 |
3,000 |
0.00% |
|
|
| 41 |
ROYAL BANK OF CANADA |
124 |
2,000 |
0.00% |
|
|
