| 1 |
HighTower Advisors, LLC |
1,951,584 |
20,414,000 |
16.56% |
|
|
| 2 |
EAGLE ASSET MANAGEMENT INC |
1,625,963 |
17,007,000 |
13.80% |
|
|
| 3 |
Palo Alto Investors LP |
1,457,200 |
15,242,000 |
12.37% |
|
|
| 4 |
MPM ASSET MANAGEMENT LLC |
1,067,236 |
11,163,000 |
9.06% |
|
|
| 5 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,006,500 |
10,528,000 |
8.54% |
|
|
| 6 |
Tekla Capital Management LLC |
970,495 |
9,644,000 |
7.82% |
|
|
| 7 |
PFM Health Sciences, LP |
582,896 |
6,097,000 |
4.95% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
375,000 |
3,923,000 |
3.18% |
|
|
| 9 |
Visium Asset Management, LP |
318,943 |
3,336,000 |
2.71% |
|
|
| 10 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
300,000 |
3,138,000 |
2.55% |
|
|
| 11 |
AXA S.A. |
293,613 |
3,071,000 |
2.49% |
|
|
| 12 |
Rhenman & Partners Asset Management AB |
256,556 |
2,684,000 |
2.18% |
|
|
| 13 |
MANAGED ACCOUNT ADVISORS LLC |
229,879 |
2,404,000 |
1.95% |
|
|
| 14 |
FARALLON CAPITAL MANAGEMENT LLC |
200,000 |
2,092,000 |
1.70% |
|
|
| 15 |
VANGUARD GROUP INC |
198,338 |
2,075,000 |
1.68% |
|
|
| 16 |
SPHERA FUNDS MANAGEMENT LTD. |
185,656 |
1,942,000 |
1.58% |
|
|
| 17 |
JPMORGAN CHASE & CO |
109,700 |
1,147,000 |
0.93% |
|
|
| 18 |
WELLS FARGO & COMPANY/MN |
88,307 |
924,000 |
0.75% |
|
|
| 19 |
SHAKER INVESTMENTS LLC/OH |
71,000 |
743,000 |
0.60% |
|
|
| 20 |
SABBY MANAGEMENT, LLC |
71,000 |
743,000 |
0.60% |
|
|
| 21 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
55,900 |
585,000 |
0.47% |
|
|
| 22 |
Bank of New York Mellon Corp |
54,843 |
573,000 |
0.46% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
54,508 |
570,000 |
0.46% |
|
|
| 24 |
TD ASSET MANAGEMENT INC |
39,200 |
410,000 |
0.33% |
|
|
| 25 |
CREDIT SUISSE AG/ |
37,203 |
389,000 |
0.32% |
|
|
| 26 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
25,000 |
262,000 |
0.21% |
|
|
| 27 |
TFS CAPITAL LLC |
23,711 |
248,000 |
0.20% |
|
|
| 28 |
D. E. Shaw & Co., Inc. |
18,774 |
196,000 |
0.16% |
|
|
| 29 |
BlackRock Institutional Trust Company, N.A. |
18,640 |
195,000 |
0.16% |
|
|
| 30 |
BlackRock Fund Advisors |
17,865 |
187,000 |
0.15% |
|
|
| 31 |
SHEPHERD KAPLAN KROCHUK, LLC |
16,774 |
175,000 |
0.14% |
|
|
| 32 |
NORTHERN TRUST CORP |
15,453 |
162,000 |
0.13% |
|
|
| 33 |
BANQUE PICTET & CIE SA |
14,796 |
155,000 |
0.13% |
|
|
| 34 |
Baldwin Investment Management, LLC |
14,593 |
153,000 |
0.12% |
|
SH |
| 35 |
Alyeska Investment Group, L.P. |
14,300 |
150,000 |
0.12% |
|
|
| 36 |
Manchester Capital Management LLC |
13,468 |
141,000 |
0.11% |
|
|
| 37 |
Partner Investment Management, L.P. |
13,366 |
140,000 |
0.11% |
|
|
| 38 |
Weiss Multi-Strategy Advisers LLC |
10,000 |
105,000 |
0.09% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
9,066 |
94,000 |
0.08% |
|
|
| 40 |
BlackRock Investment Management, LLC |
1,309 |
14,000 |
0.01% |
|
|
| 41 |
BARCLAYS PLC |
1,007 |
10,000 |
0.01% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
703 |
7,000 |
0.01% |
|
|
| 43 |
PNC FINANCIAL SERVICES GROUP, INC. |
500 |
5,000 |
0.00% |
|
|
| 44 |
FEDERATED HERMES, INC. |
426 |
4,000 |
0.00% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
71 |
1,000 |
0.00% |
|
|
| 46 |
Tower Research Capital LLC (TRC) |
113 |
1,000 |
0.00% |
|
|
| 47 |
PRIVATE TRUST CO NA |
80 |
1,000 |
0.00% |
|
|
| 48 |
ROYAL BANK OF CANADA |
12 |
0 |
0.00% |
|
|
