| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | EAGLE ASSET MANAGEMENT INC | 2,211,517 | 43,190,000 | 17.43% | ||
| 2 | HighTower Advisors, LLC | 1,929,068 | 37,675,000 | 15.21% | ||
| 3 | Palo Alto Investors LP | 1,403,800 | 27,416,000 | 11.07% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,104,396 | 21,569,000 | 8.71% | ||
| 5 | MPM ASSET MANAGEMENT LLC | 800,542 | 15,635,000 | 6.31% | ||
| 6 | Tekla Capital Management LLC | 606,482 | 11,845,000 | 4.78% | ||
| 7 | PFM Health Sciences, LP | 456,831 | 8,922,000 | 3.60% | ||
| 8 | FRONTIER CAPITAL MANAGEMENT CO LLC | 390,280 | 7,622,000 | 3.08% | ||
| 9 | BAKER BROS. ADVISORS LP | 375,000 | 7,324,000 | 2.96% | ||
| 10 | EverPoint Asset Management, LLC | 300,000 | 5,859,000 | 2.37% | ||
| 11 | BlackRock Fund Advisors | 291,765 | 5,698,000 | 2.30% | ||
| 12 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 300,000 | 5,418,000 | 2.19% | ||
| 13 | VANGUARD GROUP INC | 233,764 | 4,565,000 | 1.84% | ||
| 14 | MANAGED ACCOUNT ADVISORS LLC | 220,008 | 4,296,000 | 1.73% | ||
| 15 | AXA S.A. | 201,845 | 3,942,000 | 1.59% | ||
| 16 | FARALLON CAPITAL MANAGEMENT LLC | 200,000 | 3,906,000 | 1.58% | ||
| 17 | Rhenman & Partners Asset Management AB | 196,000 | 3,828,000 | 1.55% | ||
| 18 | JPMORGAN CHASE & CO | 168,500 | 3,291,000 | 1.33% | ||
| 19 | Candriam S.C.A. | 160,000 | 3,125,000 | 1.26% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 150,656 | 2,942,000 | 1.19% | ||
| 21 | WELLS FARGO & COMPANY/MN | 94,791 | 1,851,000 | 0.75% | ||
| 22 | CREDIT SUISSE AG/ | 79,794 | 1,558,000 | 0.63% | ||
| 23 | Bank of New York Mellon Corp | 60,122 | 1,174,000 | 0.47% | ||
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 55,900 | 1,092,000 | 0.44% | ||
| 25 | SHAKER INVESTMENTS LLC/OH | 55,000 | 1,074,000 | 0.43% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 54,661 | 1,067,000 | 0.43% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 43,611 | 852,000 | 0.34% | ||
| 28 | Opus Point Partners Management, LLC | 42,414 | 828,000 | 0.33% | ||
| 29 | TFS CAPITAL LLC | 42,061 | 821,000 | 0.33% | ||
| 30 | TD ASSET MANAGEMENT INC | 41,700 | 814,000 | 0.33% | ||
| 31 | RA CAPITAL MANAGEMENT, L.P. | 40,900 | 799,000 | 0.32% | ||
| 32 | Ghost Tree Capital, LLC | 40,000 | 781,000 | 0.32% | ||
| 33 | Polar Capital LLP | 34,800 | 680,000 | 0.27% | ||
| 34 | PURA VIDA INVESTMENTS, LLC | 33,587 | 656,000 | 0.26% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 22,614 | 442,000 | 0.18% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 21,600 | 422,000 | 0.17% | ||
| 37 | D. E. Shaw & Co., Inc. | 19,212 | 375,000 | 0.15% | ||
| 38 | DEUTSCHE BANK AG\ | 19,249 | 375,000 | 0.15% | ||
| 39 | BlackRock Institutional Trust Company, N.A. | 18,640 | 364,000 | 0.15% | ||
| 40 | RAYMOND JAMES & ASSOCIATES | 18,181 | 355,000 | 0.14% | ||
| 41 | NORTHERN TRUST CORP | 16,828 | 329,000 | 0.13% | ||
| 42 | ProShare Advisors LLC | 15,433 | 301,000 | 0.12% | ||
| 43 | Baldwin Investment Management, LLC | 14,593 | 285,000 | 0.12% | SH | |
| 44 | GOLDMAN SACHS GROUP INC | 14,296 | 279,000 | 0.11% | ||
| 45 | Manchester Capital Management LLC | 13,468 | 263,000 | 0.11% | ||
| 46 | Airain ltd | 12,897 | 252,000 | 0.10% | ||
| 47 | A.R.T. Advisors, LLC | 11,462 | 223,000 | 0.09% | ||
| 48 | Connor, Clark & Lunn Investment Management Ltd. | 10,900 | 213,000 | 0.09% | ||
| 49 | Partner Investment Management, L.P. | 10,273 | 201,000 | 0.08% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,195 | 199,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
