| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | EAGLE ASSET MANAGEMENT INC | 2,325,479 | 44,044,000 | 13.41% | ||
| 2 | HighTower Advisors, LLC | 1,930,868 | 36,571,000 | 11.14% | ||
| 3 | Palo Alto Investors LP | 1,445,100 | 27,370,000 | 8.34% | ||
| 4 | MANGROVE PARTNERS IM, LLC | 1,000,000 | 18,940,000 | 5.77% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 972,000 | 18,410,000 | 5.61% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 887,135 | 16,802,000 | 5.12% | ||
| 7 | MPM ASSET MANAGEMENT LLC | 800,542 | 15,162,000 | 4.62% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 474,500 | 8,987,000 | 2.74% | Call | |
| 9 | FRONTIER CAPITAL MANAGEMENT CO LLC | 371,996 | 7,046,000 | 2.15% | ||
| 10 | BAKER BROS. ADVISORS LP | 366,806 | 6,947,000 | 2.12% | ||
| 11 | FMR LLC | 331,400 | 6,277,000 | 1.91% | ||
| 12 | BlackRock Fund Advisors | 312,441 | 5,918,000 | 1.80% | ||
| 13 | C WorldWide Group Holding A/S | 300,000 | 5,682,000 | 1.73% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 298,300 | 5,650,000 | 1.72% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 293,200 | 5,553,000 | 1.69% | Put | |
| 16 | VANGUARD GROUP INC | 293,029 | 5,550,000 | 1.69% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 290,500 | 5,502,000 | 1.68% | Call | |
| 18 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 300,000 | 5,418,000 | 1.65% | ||
| 19 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 275,990 | 5,227,000 | 1.59% | ||
| 20 | AXA S.A. | 273,270 | 5,176,000 | 1.58% | ||
| 21 | FRANKLIN RESOURCES INC | 236,285 | 4,475,000 | 1.36% | ||
| 22 | MANAGED ACCOUNT ADVISORS LLC | 217,926 | 4,127,000 | 1.26% | ||
| 23 | Candriam S.C.A. | 185,000 | 3,505,000 | 1.07% | ||
| 24 | JPMORGAN CHASE & CO | 170,400 | 3,227,000 | 0.98% | ||
| 25 | PFM Health Sciences, LP | 166,681 | 3,157,000 | 0.96% | ||
| 26 | Sio Capital Management, LLC | 138,800 | 2,629,000 | 0.80% | Put | |
| 27 | ASCEND CAPITAL, LLC | 130,000 | 2,463,000 | 0.75% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 125,400 | 2,375,000 | 0.72% | Call | |
| 29 | DEUTSCHE BANK AG\ | 122,893 | 2,326,000 | 0.71% | ||
| 30 | Rhenman & Partners Asset Management AB | 120,053 | 2,274,000 | 0.69% | ||
| 31 | SOROS FUND MANAGEMENT LLC | 120,000 | 2,273,000 | 0.69% | ||
| 32 | CREDIT SUISSE AG/ | 108,636 | 2,058,000 | 0.63% | ||
| 33 | BlackRock Institutional Trust Company, N.A. | 107,095 | 2,028,000 | 0.62% | ||
| 34 | MORGAN STANLEY | 105,765 | 2,003,000 | 0.61% | ||
| 35 | PERCEPTIVE ADVISORS LLC | 100,000 | 1,894,000 | 0.58% | Put | |
| 36 | Ghost Tree Capital, LLC | 100,000 | 1,894,000 | 0.58% | ||
| 37 | BARCLAYS PLC | 100,600 | 1,811,000 | 0.55% | Call | |
| 38 | BARCLAYS PLC | 98,573 | 1,774,000 | 0.54% | ||
| 39 | WELLS FARGO & COMPANY/MN | 93,417 | 1,769,000 | 0.54% | ||
| 40 | BARCLAYS PLC | 88,600 | 1,595,000 | 0.49% | Put | |
| 41 | Bank of New York Mellon Corp | 77,082 | 1,459,000 | 0.44% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 72,991 | 1,382,000 | 0.42% | ||
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 58,739 | 1,112,000 | 0.34% | ||
| 44 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 55,900 | 1,059,000 | 0.32% | ||
| 45 | SHAKER INVESTMENTS LLC/OH | 55,000 | 1,042,000 | 0.32% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,026 | 947,000 | 0.29% | ||
| 47 | BLACKROCK ADVISORS LLC | 49,229 | 932,000 | 0.28% | ||
| 48 | Opus Point Partners Management, LLC | 42,414 | 803,000 | 0.24% | ||
| 49 | TD ASSET MANAGEMENT INC | 41,700 | 790,000 | 0.24% | ||
| 50 | RA CAPITAL MANAGEMENT, L.P. | 40,900 | 775,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
