| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,160,958 | 316,357,000 | 16.26% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,236,701 | 170,056,000 | 8.74% | ||
| 3 | BlackRock Finance, Inc. | 1,708,386 | 129,888,000 | 6.68% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,625,211 | 123,565,000 | 6.35% | ||
| 5 | VANGUARD GROUP INC | 1,194,809 | 90,841,000 | 4.67% | ||
| 6 | VHCP MANAGEMENT II, LLC | 1,035,657 | 78,741,000 | 4.05% | ||
| 7 | BOXER CAPITAL, LLC | 1,028,763 | 78,217,000 | 4.02% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,000,466 | 76,065,000 | 3.91% | ||
| 9 | FRANKLIN RESOURCES INC | 913,518 | 69,455,000 | 3.57% | ||
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 811,906 | 61,729,000 | 3.17% | ||
| 11 | Point72 Asset Management, L.P. | 717,514 | 54,553,000 | 2.80% | ||
| 12 | RTW INVESTMENTS, LP | 623,330 | 47,392,000 | 2.44% | ||
| 13 | Hound Partners, LLC | 576,700 | 43,846,000 | 2.25% | ||
| 14 | JANUS HENDERSON INVESTORS US LLC | 521,772 | 39,668,000 | 2.04% | ||
| 15 | BAKER BROS. ADVISORS LP | 500,000 | 38,015,000 | 1.95% | ||
| 16 | STATE STREET CORP | 489,812 | 37,236,000 | 1.91% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 448,501 | 34,100,000 | 1.75% | ||
| 18 | VIKING GLOBAL INVESTORS LP | 381,626 | 29,015,000 | 1.49% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 377,352 | 28,690,000 | 1.47% | ||
| 20 | BB BIOTECH AG | 332,800 | 25,303,000 | 1.30% | ||
| 21 | CITADEL ADVISORS LLC | 296,342 | 22,531,000 | 1.16% | ||
| 22 | PointState Capital LP | 249,067 | 18,937,000 | 0.97% | ||
| 23 | GOLDMAN SACHS GROUP INC | 227,961 | 17,332,000 | 0.89% | ||
| 24 | Avoro Capital Advisors LLC | 225,370 | 17,135,000 | 0.88% | ||
| 25 | QVT Financial LP | 220,356 | 16,754,000 | 0.86% | ||
| 26 | GREAT POINT PARTNERS LLC | 200,000 | 15,206,000 | 0.78% | ||
| 27 | JENNISON ASSOCIATES LLC | 183,786 | 13,973,000 | 0.72% | ||
| 28 | Ghost Tree Capital, LLC | 175,000 | 13,305,000 | 0.68% | ||
| 29 | PICTET ASSET MANAGEMENT LTD | 153,606 | 11,679,000 | 0.60% | ||
| 30 | Rock Springs Capital Management LP | 140,000 | 10,644,000 | 0.55% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 127,512 | 9,694,000 | 0.50% | ||
| 32 | Bain Capital Public Equity Management, LLC | 121,000 | 9,200,000 | 0.47% | ||
| 33 | Artal Group S.A. | 120,000 | 9,124,000 | 0.47% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,200 | 8,150,000 | 0.42% | Call | |
| 35 | NORTHERN TRUST CORP | 103,817 | 7,893,000 | 0.41% | ||
| 36 | DEUTSCHE BANK AG\ | 90,118 | 6,850,000 | 0.35% | ||
| 37 | Spark Investment Management LLC | 89,400 | 6,797,000 | 0.35% | ||
| 38 | CRAWFORD LAKE CAPITAL MANAGEMENT, LLC | 89,000 | 6,767,000 | 0.35% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 81,000 | 6,158,000 | 0.32% | ||
| 40 | PURA VIDA INVESTMENTS, LLC | 72,625 | 5,522,000 | 0.28% | ||
| 41 | PFM Health Sciences, LP | 70,170 | 5,335,000 | 0.27% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 70,000 | 5,322,000 | 0.27% | Call | |
| 43 | CREDIT SUISSE AG/ | 63,228 | 4,807,000 | 0.25% | ||
| 44 | Bank of New York Mellon Corp | 62,922 | 4,784,000 | 0.25% | ||
| 45 | GAM Holding AG | 62,700 | 4,767,000 | 0.25% | ||
| 46 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 60,881 | 4,629,000 | 0.24% | ||
| 47 | BARCLAYS PLC | 60,570 | 4,606,000 | 0.24% | ||
| 48 | ACUTA CAPITAL PARTNERS, LLC | 56,000 | 4,258,000 | 0.22% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 54,865 | 4,172,000 | 0.21% | ||
| 50 | TEACHERS ADVISORS, LLC | 54,217 | 4,122,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
