| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 2,171,723 | 32,923,000 | 18.72% | ||
| 2 | MPM ASSET MANAGEMENT LLC | 2,168,691 | 32,877,000 | 18.70% | ||
| 3 | FMR LLC | 2,094,464 | 31,752,000 | 18.06% | ||
| 4 | BLACKROCK ADVISORS LLC | 1,025,772 | 15,550,000 | 8.84% | ||
| 5 | ORBIMED ADVISORS LLC | 757,365 | 11,482,000 | 6.53% | ||
| 6 | ArrowMark Colorado Holdings LLC | 467,461 | 7,087,000 | 4.03% | ||
| 7 | JENNISON ASSOCIATES LLC | 383,776 | 5,818,000 | 3.31% | ||
| 8 | EcoR1 Capital, LLC | 357,365 | 5,418,000 | 3.08% | ||
| 9 | VANGUARD GROUP INC | 292,924 | 4,441,000 | 2.53% | ||
| 10 | Cormorant Asset Management, LP | 240,403 | 3,645,000 | 2.07% | ||
| 11 | BOXER CAPITAL, LLC | 234,220 | 3,551,000 | 2.02% | ||
| 12 | BlackRock Group LTD | 175,926 | 2,667,000 | 1.52% | ||
| 13 | Alyeska Investment Group, L.P. | 168,772 | 2,559,000 | 1.46% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 166,310 | 2,521,000 | 1.43% | ||
| 15 | BlackRock Fund Advisors | 130,363 | 1,976,000 | 1.12% | ||
| 16 | TIVERTON ASSET MANAGEMENT LLC | 123,136 | 1,867,000 | 1.06% | ||
| 17 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 89,200 | 1,352,000 | 0.77% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 87,035 | 1,319,000 | 0.75% | ||
| 19 | STATE STREET CORP | 55,322 | 840,000 | 0.48% | ||
| 20 | NORTHERN TRUST CORP | 52,951 | 802,000 | 0.46% | ||
| 21 | GENERAL ELECTRIC CO | 47,945 | 726,000 | 0.41% | ||
| 22 | BlackRock Finance, Inc. | 44,851 | 680,000 | 0.39% | ||
| 23 | KORNITZER CAPITAL MANAGEMENT INC /KS | 36,900 | 559,000 | 0.32% | ||
| 24 | BlackRock Investment Management, LLC | 36,068 | 547,000 | 0.31% | ||
| 25 | BlackRock Institutional Trust Company, N.A. | 26,166 | 397,000 | 0.23% | ||
| 26 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 23,591 | 358,000 | 0.20% | ||
| 27 | ALPS ADVISORS INC | 22,669 | 344,000 | 0.20% | ||
| 28 | Laurion Capital Management LP | 20,091 | 305,000 | 0.17% | ||
| 29 | MORGAN STANLEY | 17,937 | 272,000 | 0.15% | ||
| 30 | Bank of New York Mellon Corp | 16,641 | 253,000 | 0.14% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 10,760 | 163,000 | 0.09% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,100 | 154,000 | 0.09% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,787 | 148,000 | 0.08% | ||
| 34 | UBS Group AG | 8,997 | 136,000 | 0.08% | ||
| 35 | BARCLAYS PLC | 5,637 | 85,000 | 0.05% | ||
| 36 | TEACHERS ADVISORS, LLC | 4,911 | 74,000 | 0.04% | ||
| 37 | Nationwide Fund Advisors | 2,850 | 43,000 | 0.02% | ||
| 38 | AMERICAN INTERNATIONAL GROUP, INC. | 2,718 | 41,205 | 0.02% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 1,800 | 27,000 | 0.02% | ||
| 40 | WELLS FARGO & COMPANY/MN | 1,648 | 25,000 | 0.01% | ||
| 41 | STRS OHIO | 1,500 | 22,000 | 0.01% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 848 | 14,000 | 0.01% | ||
| 43 | DEUTSCHE BANK AG\ | 777 | 11,000 | 0.01% | ||
| 44 | CITIGROUP INC | 384 | 6,000 | 0.00% | ||
| 45 | BNP PARIBAS FINANCIAL MARKETS | 321 | 4,866 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
