| 1 |
WELLINGTON MANAGEMENT GROUP LLP |
2,539,820 |
34,847,000 |
21.80% |
|
|
| 2 |
MPM ASSET MANAGEMENT LLC |
2,168,691 |
29,754,000 |
18.61% |
|
|
| 3 |
BlackRock Finance, Inc. |
1,469,908 |
20,167,000 |
12.61% |
|
|
| 4 |
FMR LLC |
1,250,316 |
17,154,000 |
10.73% |
|
|
| 5 |
ArrowMark Colorado Holdings LLC |
504,697 |
6,924,000 |
4.33% |
|
|
| 6 |
ORBIMED ADVISORS LLC |
484,800 |
6,651,000 |
4.16% |
|
|
| 7 |
VANGUARD GROUP INC |
409,924 |
5,624,000 |
3.52% |
|
|
| 8 |
MILLENNIUM MANAGEMENT LLC |
297,480 |
4,081,000 |
2.55% |
|
|
| 9 |
HILLHOUSE INVESTMENT MANAGEMENT, LTD. |
245,449 |
3,368,000 |
2.11% |
|
|
| 10 |
Cormorant Asset Management, LP |
240,403 |
3,298,000 |
2.06% |
|
|
| 11 |
BOXER CAPITAL, LLC |
234,220 |
3,213,000 |
2.01% |
|
|
| 12 |
Artal Group S.A. |
200,000 |
2,744,000 |
1.72% |
|
|
| 13 |
Alyeska Investment Group, L.P. |
172,386 |
2,365,000 |
1.48% |
|
|
| 14 |
SPHERA FUNDS MANAGEMENT LTD. |
166,310 |
2,282,000 |
1.43% |
|
|
| 15 |
MORGAN STANLEY |
119,987 |
1,646,000 |
1.03% |
|
|
| 16 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
103,540 |
1,421,000 |
0.89% |
|
|
| 17 |
Point72 Asset Management, L.P. |
99,000 |
1,358,000 |
0.85% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
98,962 |
1,357,000 |
0.85% |
|
|
| 19 |
TIVERTON ASSET MANAGEMENT LLC |
83,172 |
1,141,000 |
0.71% |
|
|
| 20 |
NORTHERN TRUST CORP |
66,860 |
917,000 |
0.57% |
|
|
| 21 |
STATE STREET CORP |
61,221 |
841,000 |
0.53% |
|
|
| 22 |
ASYMMETRY CAPITAL MANAGEMENT, L.P. |
60,087 |
824,000 |
0.52% |
|
|
| 23 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
50,500 |
693,000 |
0.43% |
|
|
| 24 |
Granite Point Capital Management, L.P. |
50,000 |
686,000 |
0.43% |
|
|
| 25 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
38,130 |
523,000 |
0.33% |
|
|
| 26 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
36,900 |
506,000 |
0.32% |
|
|
| 27 |
EcoR1 Capital, LLC |
35,301 |
484,000 |
0.30% |
|
|
| 28 |
MEADOW CREEK INVESTMENT MANAGEMENT LLC |
34,510 |
474,000 |
0.30% |
|
|
| 29 |
DEUTSCHE BANK AG\ |
32,841 |
449,000 |
0.28% |
|
|
| 30 |
Bank of New York Mellon Corp |
29,227 |
401,000 |
0.25% |
|
|
| 31 |
PRELUDE CAPITAL MANAGEMENT, LLC |
28,742 |
394,000 |
0.25% |
|
|
| 32 |
ELKFORK PARTNERS LLC |
28,420 |
390,000 |
0.24% |
|
|
| 33 |
OPPENHEIMER & CO INC |
26,594 |
365,000 |
0.23% |
|
|
| 34 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
22,924 |
315,000 |
0.20% |
|
|
| 35 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
22,654 |
311,000 |
0.19% |
|
|
| 36 |
GLEN HARBOR CAPITAL MANAGEMENT LLC |
22,330 |
306,000 |
0.19% |
|
|
| 37 |
Trexquant Investment LP |
20,595 |
283,000 |
0.18% |
|
|
| 38 |
NEUBURGH ADVISERS LLC |
16,240 |
223,000 |
0.14% |
|
|
| 39 |
C WorldWide Group Holding A/S |
11,900 |
163,000 |
0.10% |
|
|
| 40 |
Numeric Investors LLC |
11,057 |
152,000 |
0.10% |
|
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
10,100 |
139,000 |
0.09% |
|
|
| 42 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,687 |
133,000 |
0.08% |
|
|
| 43 |
TEACHERS ADVISORS, LLC |
7,360 |
101,000 |
0.06% |
|
|
| 44 |
BARCLAYS PLC |
6,111 |
83,000 |
0.05% |
|
|
| 45 |
JPMORGAN CHASE & CO |
3,863 |
53,000 |
0.03% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,902 |
40,000 |
0.03% |
|
|
| 47 |
Nationwide Fund Advisors |
2,850 |
39,000 |
0.02% |
|
|
| 48 |
Creative Planning |
2,000 |
27,000 |
0.02% |
|
|
| 49 |
NEW YORK STATE COMMON RETIREMENT FUND |
1,801 |
25,000 |
0.02% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
1,648 |
23,000 |
0.01% |
|
|
