| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 6,569,645 | 212,659,000 | 35.14% | ||
| 2 | Alphabet Inc. | 2,444,652 | 79,133,000 | 13.08% | ||
| 3 | GILDER GAGNON HOWE & CO LLC | 1,877,752 | 60,783,000 | 10.04% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,439,634 | 46,601,000 | 7.70% | ||
| 5 | FMR LLC | 877,059 | 28,390,000 | 4.69% | ||
| 6 | LORD, ABBETT & CO. LLC | 815,175 | 26,387,000 | 4.36% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 342,921 | 11,100,000 | 1.83% | ||
| 8 | WELLS FARGO & COMPANY/MN | 289,797 | 9,380,000 | 1.55% | ||
| 9 | Cupps Capital Management, LLC | 283,884 | 9,189,000 | 1.52% | ||
| 10 | Artisan Partners Limited Partnership | 282,121 | 9,132,000 | 1.51% | ||
| 11 | FRONTIER CAPITAL MANAGEMENT CO LLC | 280,982 | 9,095,000 | 1.50% | ||
| 12 | BAMCO INC /NY/ | 275,114 | 8,905,000 | 1.47% | ||
| 13 | SANDLER CAPITAL MANAGEMENT | 245,700 | 7,953,000 | 1.31% | ||
| 14 | FRED ALGER MANAGEMENT, LLC | 227,262 | 7,356,000 | 1.22% | ||
| 15 | Nokota Management, LP | 208,500 | 6,749,000 | 1.12% | ||
| 16 | VANGUARD GROUP INC | 186,790 | 6,046,000 | 1.00% | ||
| 17 | BlackRock Fund Advisors | 174,609 | 5,652,000 | 0.93% | ||
| 18 | GOLDMAN SACHS GROUP INC | 159,765 | 5,172,000 | 0.85% | ||
| 19 | TCW GROUP INC | 110,328 | 3,572,000 | 0.59% | ||
| 20 | KORNITZER CAPITAL MANAGEMENT INC /KS | 110,000 | 3,561,000 | 0.59% | ||
| 21 | PRENTISS SMITH & CO INC | 101,661 | 3,291,000 | 0.54% | ||
| 22 | STATE STREET CORP | 98,825 | 3,198,000 | 0.53% | ||
| 23 | JPMORGAN CHASE & CO | 87,275 | 2,825,000 | 0.47% | ||
| 24 | NORTHERN TRUST CORP | 84,739 | 2,743,000 | 0.45% | ||
| 25 | PRINCIPAL FINANCIAL GROUP INC | 78,987 | 2,557,000 | 0.42% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 76,466 | 2,475,000 | 0.41% | ||
| 27 | MORGAN STANLEY | 61,985 | 2,006,000 | 0.33% | ||
| 28 | GOLDMAN SACHS GROUP INC | 50,000 | 1,618,000 | 0.27% | Call | |
| 29 | GOLDMAN SACHS GROUP INC | 50,000 | 1,618,000 | 0.27% | Put | |
| 30 | EVENTIDE ASSET MANAGEMENT, LLC | 49,200 | 1,593,000 | 0.26% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 47,661 | 1,542,000 | 0.25% | ||
| 32 | Spot Trading L.L.C | 45,000 | 1,457,000 | 0.24% | Put | |
| 33 | Bank of New York Mellon Corp | 44,928 | 1,454,000 | 0.24% | ||
| 34 | BLACKROCK ADVISORS LLC | 40,602 | 1,314,000 | 0.22% | ||
| 35 | Forward Management, LLC | 54,210 | 1,310,000 | 0.22% | ||
| 36 | Calamos Advisors LLC | 33,475 | 1,084,000 | 0.18% | ||
| 37 | AMERIPRISE FINANCIAL INC | 32,805 | 1,062,000 | 0.18% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 32,693 | 1,058,000 | 0.17% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 30,357 | 983,000 | 0.16% | ||
| 40 | PRIMECAP MANAGEMENT CO/CA/ | 26,000 | 842,000 | 0.14% | ||
| 41 | CREDIT SUISSE AG/ | 22,105 | 715,000 | 0.12% | ||
| 42 | D L CARLSON INVESTMENT GROUP INC | 20,275 | 656,000 | 0.11% | ||
| 43 | Spot Trading L.L.C | 20,242 | 655,000 | 0.11% | ||
| 44 | BlackRock Investment Management, LLC | 19,865 | 643,000 | 0.11% | ||
| 45 | TEACHERS ADVISORS, LLC | 16,661 | 539,000 | 0.09% | ||
| 46 | CADENCE CAPITAL MANAGEMENT LLC | 16,540 | 535,000 | 0.09% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 18,107 | 530,000 | 0.09% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,262 | 495,000 | 0.08% | ||
| 49 | NOMURA HOLDINGS INC | 14,400 | 479,000 | 0.08% | Call | |
| 50 | SEI TRUST CO | 13,283 | 430,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
