| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 4,927,234 | 237,049,000 | 21.29% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 3,749,960 | 180,411,000 | 16.20% | ||
| 3 | FMR LLC | 2,310,900 | 111,177,000 | 9.98% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,194,875 | 57,486,000 | 5.16% | ||
| 5 | Alphabet Inc. | 1,144,652 | 55,069,000 | 4.95% | ||
| 6 | LORD, ABBETT & CO. LLC | 1,027,423 | 49,429,000 | 4.44% | ||
| 7 | BAMCO INC /NY/ | 843,768 | 40,594,000 | 3.65% | ||
| 8 | BlackRock Fund Advisors | 712,857 | 34,296,000 | 3.08% | ||
| 9 | STATE STREET CORP | 675,493 | 32,500,000 | 2.92% | ||
| 10 | VANGUARD GROUP INC | 587,411 | 28,260,000 | 2.54% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 511,894 | 24,627,000 | 2.21% | ||
| 12 | JPMORGAN CHASE & CO | 345,312 | 16,613,000 | 1.49% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 344,999 | 16,598,000 | 1.49% | ||
| 14 | CSS LLC/IL | 340,214 | 16,368,000 | 1.47% | ||
| 15 | BANK OF AMERICA CORP /DE/ | 339,834 | 16,350,000 | 1.47% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 292,100 | 14,053,000 | 1.26% | Put | |
| 17 | CHESAPEAKE PARTNERS MANAGEMENT CO INC/MD | 221,538 | 10,658,000 | 0.96% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 200,000 | 9,622,000 | 0.86% | Call | |
| 19 | BANK OF AMERICA CORP /DE/ | 174,700 | 8,405,000 | 0.75% | Put | |
| 20 | BARCLAYS PLC | 167,000 | 8,016,000 | 0.72% | Call | |
| 21 | BAILLIE GIFFORD & CO | 165,000 | 7,938,000 | 0.71% | ||
| 22 | NORTHERN TRUST CORP | 157,553 | 7,580,000 | 0.68% | ||
| 23 | Chevy Chase Trust Holdings, LLC | 129,561 | 6,233,000 | 0.56% | ||
| 24 | BAKER BROS. ADVISORS LP | 124,255 | 5,978,000 | 0.54% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 113,807 | 5,474,000 | 0.49% | ||
| 26 | CSS LLC/IL | 101,400 | 4,878,000 | 0.44% | Put | |
| 27 | OPPENHEIMER & CO INC | 91,920 | 4,423,000 | 0.40% | ||
| 28 | Pentwater Capital Management LP | 85,200 | 4,099,000 | 0.37% | ||
| 29 | Bank of New York Mellon Corp | 80,759 | 3,885,000 | 0.35% | ||
| 30 | EQUITEC PROPRIETARY MARKETS, LLC | 77,197 | 3,714,000 | 0.33% | ||
| 31 | Jefferies Group LLC | 76,100 | 3,661,000 | 0.33% | Put | |
| 32 | Weiss Multi-Strategy Advisers LLC | 74,100 | 3,565,000 | 0.32% | Call | |
| 33 | BLAIR WILLIAM & CO/IL | 70,574 | 3,395,000 | 0.30% | ||
| 34 | NORGES BANK | 63,563 | 3,058,000 | 0.27% | ||
| 35 | CITADEL ADVISORS LLC | 63,402 | 3,050,000 | 0.27% | ||
| 36 | MACQUARIE GROUP LTD | 60,000 | 2,887,000 | 0.26% | ||
| 37 | EQUITEC PROPRIETARY MARKETS, LLC | 58,400 | 2,810,000 | 0.25% | Call | |
| 38 | EQUITEC PROPRIETARY MARKETS, LLC | 58,300 | 2,805,000 | 0.25% | Put | |
| 39 | Spot Trading L.L.C | 57,400 | 2,762,000 | 0.25% | Call | |
| 40 | Walleye Trading LLC | 56,400 | 2,713,000 | 0.24% | Call | |
| 41 | GOLDMAN SACHS GROUP INC | 54,156 | 2,605,000 | 0.23% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 53,590 | 2,578,000 | 0.23% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 52,543 | 2,528,000 | 0.23% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 52,019 | 2,503,000 | 0.22% | ||
| 45 | Sculptor Capital LP | 51,300 | 2,468,000 | 0.22% | Call | |
| 46 | Jefferies Group LLC | 50,000 | 2,406,000 | 0.22% | Call | |
| 47 | GOLDMAN SACHS GROUP INC | 50,000 | 2,406,000 | 0.22% | Put | |
| 48 | GOLDMAN SACHS GROUP INC | 50,000 | 2,406,000 | 0.22% | Call | |
| 49 | MOORE CAPITAL MANAGEMENT, LP | 50,000 | 2,406,000 | 0.22% | Put | |
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,900 | 2,353,000 | 0.21% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
