| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 4,927,234 | 132,838,000 | 25.83% | ||
| 2 | FMR LLC | 2,654,112 | 71,555,000 | 13.91% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,148,923 | 57,936,000 | 11.27% | ||
| 4 | GILDER GAGNON HOWE & CO LLC | 1,883,585 | 50,781,000 | 9.87% | ||
| 5 | LORD, ABBETT & CO. LLC | 1,192,937 | 32,162,000 | 6.25% | ||
| 6 | Alphabet Inc. | 1,144,652 | 30,860,000 | 6.00% | ||
| 7 | Bain Capital Public Equity Management, LLC | 446,400 | 12,035,000 | 2.34% | ||
| 8 | VANGUARD GROUP INC | 330,782 | 8,918,000 | 1.73% | ||
| 9 | WELLS FARGO & COMPANY/MN | 322,577 | 8,697,000 | 1.69% | ||
| 10 | Artisan Partners Limited Partnership | 310,941 | 8,383,000 | 1.63% | ||
| 11 | BlackRock Fund Advisors | 306,697 | 8,269,000 | 1.61% | ||
| 12 | BAMCO INC /NY/ | 240,946 | 6,496,000 | 1.26% | ||
| 13 | FRED ALGER MANAGEMENT, LLC | 220,994 | 5,958,000 | 1.16% | ||
| 14 | Nokota Management, LP | 208,500 | 5,621,000 | 1.09% | ||
| 15 | GOLDMAN SACHS GROUP INC | 193,160 | 5,208,000 | 1.01% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 175,000 | 4,718,000 | 0.92% | ||
| 17 | STATE STREET CORP | 166,930 | 4,500,000 | 0.87% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 163,499 | 4,408,000 | 0.86% | ||
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 137,021 | 3,694,000 | 0.72% | ||
| 20 | PRENTISS SMITH & CO INC | 100,244 | 2,703,000 | 0.53% | ||
| 21 | TCW GROUP INC | 88,699 | 2,391,000 | 0.46% | ||
| 22 | KORNITZER CAPITAL MANAGEMENT INC /KS | 85,000 | 2,292,000 | 0.45% | ||
| 23 | NORTHERN TRUST CORP | 83,302 | 2,246,000 | 0.44% | ||
| 24 | BAKER BROS. ADVISORS LP | 78,162 | 2,107,000 | 0.41% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,500 | 2,089,000 | 0.41% | Put | |
| 26 | MILLENNIUM MANAGEMENT LLC | 77,500 | 2,089,000 | 0.41% | Put | |
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,855 | 1,506,000 | 0.29% | ||
| 28 | SANDLER CAPITAL MANAGEMENT | 53,700 | 1,448,000 | 0.28% | ||
| 29 | BLACKROCK ADVISORS LLC | 53,308 | 1,437,000 | 0.28% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 52,989 | 1,428,000 | 0.28% | ||
| 31 | Bank of New York Mellon Corp | 52,288 | 1,410,000 | 0.27% | ||
| 32 | GOLDMAN SACHS GROUP INC | 50,000 | 1,348,000 | 0.26% | Put | |
| 33 | GOLDMAN SACHS GROUP INC | 50,000 | 1,348,000 | 0.26% | Call | |
| 34 | BARCLAYS PLC | 50,000 | 1,300,000 | 0.25% | Call | |
| 35 | JPMORGAN CHASE & CO | 44,887 | 1,210,000 | 0.24% | ||
| 36 | PRICE T ROWE ASSOCIATES INC /MD/ | 44,413 | 1,197,000 | 0.23% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,753 | 1,126,000 | 0.22% | ||
| 38 | BlackRock Investment Management, LLC | 37,952 | 1,023,000 | 0.20% | ||
| 39 | Jefferies Group LLC | 36,400 | 981,000 | 0.19% | Call | |
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 34,105 | 919,000 | 0.18% | ||
| 41 | Calamos Advisors LLC | 32,515 | 877,000 | 0.17% | ||
| 42 | AMERIPRISE FINANCIAL INC | 31,980 | 863,000 | 0.17% | ||
| 43 | JANE STREET GROUP, LLC | 29,849 | 805,000 | 0.16% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,666 | 692,000 | 0.13% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,500 | 687,000 | 0.13% | ||
| 46 | Spot Trading L.L.C | 25,000 | 674,000 | 0.13% | Put | |
| 47 | TEACHERS ADVISORS, LLC | 24,853 | 670,000 | 0.13% | ||
| 48 | Jasper Ridge Partners, L.P. | 21,741 | 586,000 | 0.11% | ||
| 49 | MORGAN STANLEY | 21,005 | 567,000 | 0.11% | ||
| 50 | ROYAL BANK OF CANADA | 20,500 | 553,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
