| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 4,927,234 | 109,483,000 | 22.47% | ||
| 2 | FMR LLC | 3,223,812 | 71,633,000 | 14.70% | ||
| 3 | GILDER GAGNON HOWE & CO LLC | 3,044,610 | 67,651,000 | 13.89% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,698,369 | 37,738,000 | 7.75% | ||
| 5 | LORD, ABBETT & CO. LLC | 1,160,818 | 25,793,000 | 5.29% | ||
| 6 | Alphabet Inc. | 1,144,652 | 25,434,000 | 5.22% | ||
| 7 | STATE STREET CORP | 915,064 | 20,332,000 | 4.17% | ||
| 8 | Bain Capital Public Equity Management, LLC | 895,800 | 19,905,000 | 4.09% | ||
| 9 | BlackRock Fund Advisors | 682,459 | 15,164,000 | 3.11% | ||
| 10 | VANGUARD GROUP INC | 628,233 | 13,959,000 | 2.87% | ||
| 11 | JPMORGAN CHASE & CO | 362,519 | 8,056,000 | 1.65% | ||
| 12 | FRED ALGER MANAGEMENT, LLC | 223,834 | 4,974,000 | 1.02% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 194,055 | 4,312,000 | 0.89% | ||
| 14 | BAILLIE GIFFORD & CO | 165,000 | 3,666,000 | 0.75% | ||
| 15 | NORTHERN TRUST CORP | 154,229 | 3,427,000 | 0.70% | ||
| 16 | BAKER BROS. ADVISORS LP | 126,147 | 2,803,000 | 0.58% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 120,167 | 2,670,000 | 0.55% | ||
| 18 | Chevy Chase Trust Holdings, LLC | 116,867 | 2,597,000 | 0.53% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 113,900 | 2,531,000 | 0.52% | Put | |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 111,181 | 2,470,000 | 0.51% | ||
| 21 | EQUITEC PROPRIETARY MARKETS, LLC | 95,700 | 2,125,000 | 0.44% | Put | |
| 22 | OPPENHEIMER & CO INC | 94,319 | 2,096,000 | 0.43% | ||
| 23 | BAMCO INC /NY/ | 93,600 | 2,080,000 | 0.43% | ||
| 24 | ALLIANCEBERNSTEIN L.P. | 91,380 | 2,030,000 | 0.42% | ||
| 25 | HARBOURVEST PARTNERS LLC | 87,991 | 1,955,000 | 0.40% | ||
| 26 | BLAIR WILLIAM & CO/IL | 87,154 | 1,936,000 | 0.40% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 80,000 | 1,778,000 | 0.36% | Call | |
| 28 | Bank of New York Mellon Corp | 72,820 | 1,619,000 | 0.33% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 70,953 | 1,577,000 | 0.32% | ||
| 30 | EQUITEC PROPRIETARY MARKETS, LLC | 64,487 | 1,433,000 | 0.29% | ||
| 31 | NORGES BANK | 63,563 | 1,412,000 | 0.29% | ||
| 32 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 62,254 | 1,383,284 | 0.28% | ||
| 33 | BlackRock Group LTD | 57,098 | 1,269,000 | 0.26% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 52,943 | 1,176,000 | 0.24% | ||
| 35 | GROUP ONE TRADING LLC | 51,876 | 1,153,000 | 0.24% | ||
| 36 | GOLDMAN SACHS GROUP INC | 50,000 | 1,111,000 | 0.23% | Put | |
| 37 | GOLDMAN SACHS GROUP INC | 50,000 | 1,111,000 | 0.23% | Call | |
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 48,195 | 1,071,000 | 0.22% | ||
| 39 | CREDIT SUISSE AG/ | 39,698 | 882,000 | 0.18% | ||
| 40 | BlackRock Investment Management, LLC | 38,525 | 856,000 | 0.18% | ||
| 41 | J&P(CHINA)CAPITAL MANAGEMENT CO.,LTD | 38,276 | 850,000 | 0.17% | ||
| 42 | DEUTSCHE BANK AG\ | 27,875 | 617,000 | 0.13% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,756 | 572,000 | 0.12% | ||
| 44 | TEACHERS ADVISORS, LLC | 24,784 | 551,000 | 0.11% | ||
| 45 | MORGAN STANLEY | 23,173 | 515,000 | 0.11% | ||
| 46 | ProShare Advisors LLC | 21,755 | 483,000 | 0.10% | ||
| 47 | GOLDMAN SACHS GROUP INC | 21,547 | 479,000 | 0.10% | ||
| 48 | RENAISSANCE TECHNOLOGIES LLC | 19,500 | 433,000 | 0.09% | ||
| 49 | Calamos Advisors LLC | 18,310 | 407,000 | 0.08% | ||
| 50 | Swiss National Bank | 17,500 | 389,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
