| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 1,388,079 | 6,688,000 | 25.11% | ||
| 2 | ORBIMED ADVISORS LLC | 1,360,224 | 6,611,000 | 24.82% | ||
| 3 | Rock Springs Capital Management LP | 524,089 | 2,547,000 | 9.56% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 521,550 | 2,535,000 | 9.52% | ||
| 5 | BAKER BROS. ADVISORS LP | 404,230 | 1,965,000 | 7.38% | ||
| 6 | DAFNA Capital Management LLC | 350,392 | 1,703,000 | 6.39% | ||
| 7 | VHCP MANAGEMENT II, LLC | 350,133 | 1,527,000 | 5.73% | ||
| 8 | Sio Capital Management, LLC | 141,874 | 690,000 | 2.59% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 105,893 | 515,000 | 1.93% | ||
| 10 | Alyeska Investment Group, L.P. | 100,000 | 486,000 | 1.82% | ||
| 11 | NORGES BANK | 70,000 | 340,000 | 1.28% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 62,654 | 304,000 | 1.14% | ||
| 13 | GOLDMAN SACHS GROUP INC | 56,234 | 273,000 | 1.02% | ||
| 14 | Ghost Tree Capital, LLC | 50,000 | 243,000 | 0.91% | ||
| 15 | CITADEL ADVISORS LLC | 12,859 | 62,000 | 0.23% | ||
| 16 | BlackRock Fund Advisors | 11,035 | 54,000 | 0.20% | ||
| 17 | UBS Group AG | 7,200 | 35,000 | 0.13% | ||
| 18 | VHCP Management, LLC | 6,000 | 29,000 | 0.11% | ||
| 19 | WELLS FARGO & COMPANY/MN | 2,300 | 11,000 | 0.04% | ||
| 20 | Tower Research Capital LLC (TRC) | 776 | 4,000 | 0.02% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 845 | 4,000 | 0.02% | ||
| 22 | BlackRock Investment Management, LLC | 821 | 4,000 | 0.02% | ||
| 23 | DEUTSCHE BANK AG\ | 925 | 4,000 | 0.02% | ||
| 24 | WOLVERINE TRADING LP /BD | 719 | 3,760 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
