| 1 |
JENNISON ASSOCIATES LLC |
1,445,713 |
6,289,000 |
25.81% |
|
|
| 2 |
ORBIMED ADVISORS LLC |
1,360,224 |
5,917,000 |
24.28% |
|
|
| 3 |
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
524,929 |
2,283,000 |
9.37% |
|
|
| 4 |
Rock Springs Capital Management LP |
524,089 |
2,280,000 |
9.36% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
404,230 |
1,758,000 |
7.21% |
|
|
| 6 |
DAFNA Capital Management LLC |
350,392 |
1,524,000 |
6.25% |
|
|
| 7 |
VHCP MANAGEMENT II, LLC |
350,133 |
1,523,000 |
6.25% |
|
|
| 8 |
Sio Capital Management, LLC |
188,485 |
820,000 |
3.36% |
|
|
| 9 |
Alyeska Investment Group, L.P. |
119,707 |
521,000 |
2.14% |
|
|
| 10 |
PERCEPTIVE ADVISORS LLC |
103,585 |
451,000 |
1.85% |
|
|
| 11 |
NORGES BANK |
63,200 |
275,000 |
1.13% |
|
|
| 12 |
VANGUARD GROUP INC |
54,958 |
239,000 |
0.98% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
23,311 |
101,000 |
0.41% |
|
|
| 14 |
LEE FINANCIAL CORP |
22,408 |
97,000 |
0.40% |
|
|
| 15 |
WELLS FARGO & COMPANY/MN |
17,281 |
75,000 |
0.31% |
|
|
| 16 |
BlackRock Fund Advisors |
13,810 |
60,000 |
0.25% |
|
|
| 17 |
Spark Investment Management LLC |
12,000 |
52,000 |
0.21% |
|
|
| 18 |
GOLDMAN SACHS GROUP INC |
10,386 |
45,000 |
0.18% |
|
|
| 19 |
VHCP Management, LLC |
6,000 |
26,000 |
0.11% |
|
|
| 20 |
IFP ADVISORS, INC |
2,860 |
12,000 |
0.05% |
|
|
| 21 |
MORGAN STANLEY |
2,732 |
12,000 |
0.05% |
|
|
| 22 |
BlackRock Investment Management, LLC |
821 |
4,000 |
0.02% |
|
|
| 23 |
UBS Group AG |
800 |
3,000 |
0.01% |
|
|
| 24 |
ACADIAN ASSET MANAGEMENT LLC |
484 |
2,000 |
0.01% |
|
|
| 25 |
Tower Research Capital LLC (TRC) |
200 |
1,000 |
0.00% |
|
|
| 26 |
BANK OF MONTREAL /CAN/ |
20 |
0 |
0.00% |
|
|
