| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 1,424,947 | 9,131,000 | 24.05% | ||
| 2 | ORBIMED ADVISORS LLC | 1,360,224 | 8,719,000 | 22.96% | ||
| 3 | UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 524,929 | 3,365,000 | 8.86% | ||
| 4 | Rock Springs Capital Management LP | 524,089 | 3,359,000 | 8.85% | ||
| 5 | BAKER BROS. ADVISORS LP | 404,230 | 2,591,000 | 6.82% | ||
| 6 | DAFNA Capital Management LLC | 350,392 | 2,246,000 | 5.91% | ||
| 7 | VHCP MANAGEMENT II, LLC | 350,133 | 2,235,000 | 5.89% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 336,134 | 2,155,000 | 5.68% | ||
| 9 | Sio Capital Management, LLC | 154,332 | 989,000 | 2.60% | ||
| 10 | Alyeska Investment Group, L.P. | 109,645 | 703,000 | 1.85% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 103,585 | 664,000 | 1.75% | ||
| 12 | NORGES BANK | 63,200 | 387,000 | 1.02% | ||
| 13 | Ghost Tree Capital, LLC | 50,000 | 321,000 | 0.85% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 35,955 | 230,000 | 0.61% | ||
| 15 | GOLDMAN SACHS GROUP INC | 33,026 | 212,000 | 0.56% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 19,219 | 123,000 | 0.32% | ||
| 17 | UBS Group AG | 17,371 | 112,000 | 0.29% | ||
| 18 | VANGUARD GROUP INC | 14,636 | 94,000 | 0.25% | ||
| 19 | BlackRock Fund Advisors | 13,160 | 84,000 | 0.22% | ||
| 20 | TLP GROUP LLC | 11,913 | 76,000 | 0.20% | ||
| 21 | CREDIT SUISSE AG/ | 10,000 | 64,000 | 0.17% | ||
| 22 | VHCP Management, LLC | 6,000 | 38,000 | 0.10% | ||
| 23 | MORGAN STANLEY | 3,790 | 25,000 | 0.07% | ||
| 24 | IFP ADVISORS, INC | 2,860 | 18,000 | 0.05% | ||
| 25 | WELLS FARGO & COMPANY/MN | 2,800 | 18,000 | 0.05% | ||
| 26 | Tower Research Capital LLC (TRC) | 703 | 5,000 | 0.01% | ||
| 27 | BlackRock Investment Management, LLC | 821 | 5,000 | 0.01% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 445 | 3,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
