| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Cormorant Asset Management, LP | 2,333,333 | 20,860,000 | 19.66% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 1,644,300 | 14,701,000 | 13.85% | ||
| 3 | FMR LLC | 1,029,600 | 9,205,000 | 8.67% | ||
| 4 | Rock Springs Capital Management LP | 935,000 | 8,359,000 | 7.88% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 712,062 | 6,365,000 | 6.00% | ||
| 6 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 600,000 | 5,364,000 | 5.05% | ||
| 7 | VANGUARD GROUP INC | 585,405 | 5,234,000 | 4.93% | ||
| 8 | BlackRock Fund Advisors | 551,171 | 4,927,000 | 4.64% | ||
| 9 | MARSHALL WACE, LLP | 449,820 | 4,021,000 | 3.79% | ||
| 10 | ORBIMED ADVISORS LLC | 300,000 | 2,682,000 | 2.53% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 300,000 | 2,682,000 | 2.53% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 291,716 | 2,608,000 | 2.46% | ||
| 13 | Opaleye Management Inc. | 270,000 | 2,414,000 | 2.27% | ||
| 14 | Laurion Capital Management LP | 204,500 | 1,828,000 | 1.72% | ||
| 15 | ACUTA CAPITAL PARTNERS, LLC | 175,000 | 1,565,000 | 1.47% | ||
| 16 | TUDOR INVESTMENT CORP ET AL | 132,432 | 1,184,000 | 1.12% | ||
| 17 | AWM Investment Company, Inc. | 125,000 | 1,117,000 | 1.05% | ||
| 18 | NEXTHERA CAPITAL LP | 120,763 | 1,080,000 | 1.02% | ||
| 19 | STATE STREET CORP | 102,278 | 911,000 | 0.86% | ||
| 20 | FIRST MANHATTAN CO. LLC. | 100,000 | 894,000 | 0.84% | ||
| 21 | NORTHERN TRUST CORP | 91,540 | 818,000 | 0.77% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 90,728 | 811,000 | 0.76% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 87,062 | 778,000 | 0.73% | ||
| 24 | MONASHEE INVESTMENT MANAGEMENT LLC | 75,000 | 671,000 | 0.63% | ||
| 25 | KORNITZER CAPITAL MANAGEMENT INC /KS | 75,000 | 670,000 | 0.63% | ||
| 26 | NORGES BANK | 46,685 | 417,000 | 0.39% | ||
| 27 | GOLDMAN SACHS GROUP INC | 32,880 | 294,000 | 0.28% | ||
| 28 | BlackRock Investment Management, LLC | 32,450 | 290,000 | 0.27% | ||
| 29 | Bank of New York Mellon Corp | 31,419 | 281,000 | 0.26% | ||
| 30 | MORGAN STANLEY | 29,001 | 260,000 | 0.25% | ||
| 31 | Swiss National Bank | 28,200 | 252,000 | 0.24% | ||
| 32 | STIFEL FINANCIAL CORP | 27,050 | 242,000 | 0.23% | ||
| 33 | Neuberger Berman Group LLC | 25,000 | 224,000 | 0.21% | ||
| 34 | ELLINGTON MANAGEMENT GROUP LLC | 22,700 | 203,000 | 0.19% | ||
| 35 | ALPS ADVISORS INC | 19,765 | 177,000 | 0.17% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,000 | 152,000 | 0.14% | ||
| 37 | DEUTSCHE BANK AG\ | 15,257 | 134,000 | 0.13% | ||
| 38 | ProShare Advisors LLC | 14,915 | 133,000 | 0.13% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 14,730 | 132,000 | 0.12% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,000 | 126,000 | 0.12% | ||
| 41 | SUNTRUST BANKS INC | 13,300 | 118,000 | 0.11% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,070 | 117,000 | 0.11% | ||
| 43 | TEACHERS ADVISORS, LLC | 12,918 | 115,000 | 0.11% | ||
| 44 | CREDIT SUISSE AG/ | 12,708 | 114,000 | 0.11% | ||
| 45 | A.R.T. Advisors, LLC | 11,400 | 101,000 | 0.10% | ||
| 46 | Trexquant Investment LP | 10,700 | 96,000 | 0.09% | ||
| 47 | CITIGROUP INC | 9,722 | 87,000 | 0.08% | ||
| 48 | Nationwide Fund Advisors | 5,360 | 48,000 | 0.05% | ||
| 49 | WELLS FARGO & COMPANY/MN | 3,939 | 35,000 | 0.03% | ||
| 50 | BARCLAYS PLC | 3,788 | 33,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
