| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRUDENTIAL PLC | 870,905 | 51,706,000 | 11.55% | ||
| 2 | Capital Research Global Investors | 808,500 | 48,001,000 | 10.72% | ||
| 3 | FMR LLC | 807,827 | 47,960,000 | 10.71% | ||
| 4 | FARALLON CAPITAL MANAGEMENT LLC | 664,000 | 39,422,000 | 8.80% | ||
| 5 | VHCP Management, LLC | 644,376 | 38,257,000 | 8.54% | ||
| 6 | FRANKLIN RESOURCES INC | 471,500 | 27,993,000 | 6.25% | ||
| 7 | FEDERATED HERMES, INC. | 327,814 | 19,463,000 | 4.35% | ||
| 8 | Redmile Group, LLC | 323,583 | 19,211,000 | 4.29% | ||
| 9 | WELLS FARGO & COMPANY/MN | 323,040 | 19,179,000 | 4.28% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 298,839 | 17,742,000 | 3.96% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 281,840 | 16,733,000 | 3.74% | ||
| 12 | JANUS HENDERSON INVESTORS US LLC | 265,745 | 15,777,000 | 3.52% | ||
| 13 | MORGAN STANLEY | 215,440 | 12,790,000 | 2.86% | ||
| 14 | JENNISON ASSOCIATES LLC | 190,573 | 11,314,000 | 2.53% | ||
| 15 | CHESAPEAKE PARTNERS MANAGEMENT CO INC/MD | 155,355 | 9,223,000 | 2.06% | ||
| 16 | Abingworth LLP | 102,200 | 6,067,000 | 1.36% | ||
| 17 | ORBIMED ADVISORS LLC | 95,500 | 5,670,000 | 1.27% | ||
| 18 | Manatuck Hill Partners, LLC | 58,900 | 3,497,000 | 0.78% | ||
| 19 | Tourbillon Capital Partners, L.P. | 56,000 | 3,325,000 | 0.74% | ||
| 20 | CITADEL ADVISORS LLC | 53,187 | 3,157,000 | 0.71% | ||
| 21 | DRIEHAUS CAPITAL MANAGEMENT LLC | 47,490 | 2,819,000 | 0.63% | ||
| 22 | LORD, ABBETT & CO. LLC | 42,828 | 2,543,000 | 0.57% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,003 | 2,316,000 | 0.52% | ||
| 24 | PDT Partners, LLC | 37,411 | 2,221,000 | 0.50% | ||
| 25 | MOORE CAPITAL MANAGEMENT, LP | 34,200 | 2,030,000 | 0.45% | ||
| 26 | A.R.T. Advisors, LLC | 31,548 | 1,873,000 | 0.42% | ||
| 27 | Nationwide Fund Advisors | 26,900 | 1,597,000 | 0.36% | ||
| 28 | Ghost Tree Capital, LLC | 25,000 | 1,484,000 | 0.33% | ||
| 29 | Iguana Healthcare Management, LLC | 25,000 | 1,484,000 | 0.33% | ||
| 30 | TURNER INVESTMENTS LLC | 24,470 | 1,453,000 | 0.32% | ||
| 31 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 22,200 | 1,318,000 | 0.29% | ||
| 32 | CREDIT SUISSE AG/ | 18,801 | 1,116,000 | 0.25% | ||
| 33 | Rock Springs Capital Management LP | 17,750 | 1,054,000 | 0.24% | ||
| 34 | COLUMBUS CIRCLE INVESTORS | 16,761 | 995,000 | 0.22% | ||
| 35 | DEUTSCHE BANK AG\ | 15,700 | 931,000 | 0.21% | ||
| 36 | GOLDMAN SACHS GROUP INC | 10,000 | 594,000 | 0.13% | Call | |
| 37 | GOLDMAN SACHS GROUP INC | 10,000 | 594,000 | 0.13% | Put | |
| 38 | Ulysses Management LLC | 9,700 | 575,889 | 0.13% | ||
| 39 | SG Americas Securities, LLC | 6,900 | 410,000 | 0.09% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 6,692 | 397,000 | 0.09% | ||
| 41 | TD ASSET MANAGEMENT INC | 6,600 | 392,000 | 0.09% | ||
| 42 | UBS AG | 6,479 | 385,000 | 0.09% | ||
| 43 | JANE STREET GROUP, LLC | 6,226 | 346,000 | 0.08% | ||
| 44 | Commonwealth Equity Services, Inc | 5,645 | 335,000 | 0.07% | ||
| 45 | MILLENNIUM MANAGEMENT LLC | 5,094 | 302,000 | 0.07% | ||
| 46 | BLUE ARROW CAPITAL MANAGEMENT LLC | 5,000 | 297,000 | 0.07% | ||
| 47 | Schonfeld Group Holdings LLC | 4,454 | 264,000 | 0.06% | ||
| 48 | ROYAL BANK OF CANADA | 4,115 | 244,000 | 0.05% | ||
| 49 | PEAK6 Group LLC | 3,400 | 202,000 | 0.05% | Call | |
| 50 | GROUP ONE TRADING LLC | 2,665 | 158,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
