| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 2,610,674 | 238,537,000 | 17.64% | ||
| 2 | FMR LLC | 2,176,499 | 198,867,000 | 14.71% | ||
| 3 | PRUDENTIAL PLC | 1,131,600 | 103,394,000 | 7.65% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 833,115 | 76,121,000 | 5.63% | ||
| 5 | Bank of New York Mellon Corp | 812,940 | 74,278,000 | 5.49% | ||
| 6 | BANK OF AMERICA CORP /DE/ | 708,805 | 64,764,000 | 4.79% | ||
| 7 | FEDERATED HERMES, INC. | 590,200 | 53,927,000 | 3.99% | ||
| 8 | Capital World Investors | 437,100 | 39,938,000 | 2.95% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 391,122 | 35,737,000 | 2.64% | ||
| 10 | ORBIMED ADVISORS LLC | 377,100 | 34,456,000 | 2.55% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 346,121 | 31,625,000 | 2.34% | ||
| 12 | VHCP Management, LLC | 311,853 | 28,494,000 | 2.11% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 300,000 | 27,411,000 | 2.03% | Put | |
| 14 | WELLS FARGO & COMPANY/MN | 299,524 | 27,367,000 | 2.02% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 283,900 | 25,940,000 | 1.92% | Put | |
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 253,000 | 23,117,000 | 1.71% | Call | |
| 17 | BlackRock Fund Advisors | 211,420 | 19,317,000 | 1.43% | ||
| 18 | HAYMAN CAPITAL MANAGEMENT, L.P. | 210,715 | 19,253,000 | 1.42% | ||
| 19 | CLOUGH CAPITAL PARTNERS L P | 193,027 | 17,637,000 | 1.30% | ||
| 20 | JENNISON ASSOCIATES LLC | 192,343 | 17,574,000 | 1.30% | ||
| 21 | Lamond Capital Partners LLC | 120,000 | 10,964,000 | 0.81% | ||
| 22 | MORGAN STANLEY | 115,024 | 10,510,000 | 0.78% | ||
| 23 | FRANKLIN RESOURCES INC | 110,274 | 10,076,000 | 0.75% | ||
| 24 | GREAT POINT PARTNERS LLC | 103,800 | 9,484,000 | 0.70% | Call | |
| 25 | GREAT POINT PARTNERS LLC | 100,000 | 9,137,000 | 0.68% | Put | |
| 26 | OppenheimerFunds, Inc. | 1,200,000 | 9,137,000 | 0.68% | ||
| 27 | Tekla Capital Management LLC | 94,000 | 8,589,000 | 0.64% | ||
| 28 | Fiera Capital Corp | 93,300 | 8,525,000 | 0.63% | ||
| 29 | Rock Springs Capital Management LP | 85,500 | 7,812,000 | 0.58% | ||
| 30 | D. E. Shaw & Co., Inc. | 80,200 | 7,328,000 | 0.54% | Put | |
| 31 | GOLDMAN SACHS GROUP INC | 75,000 | 6,853,000 | 0.51% | Put | |
| 32 | SABBY MANAGEMENT, LLC | 71,757 | 6,556,000 | 0.48% | ||
| 33 | JPMORGAN CHASE & CO | 69,587 | 6,358,000 | 0.47% | ||
| 34 | EVENTIDE ASSET MANAGEMENT, LLC | 68,700 | 6,277,000 | 0.46% | ||
| 35 | Asset Management One Co., Ltd. | 67,396 | 5,983,000 | 0.44% | ||
| 36 | SPHERA FUNDS MANAGEMENT LTD. | 43,100 | 3,938,000 | 0.29% | ||
| 37 | Advisors Asset Management, Inc. | 42,563 | 3,889,000 | 0.29% | ||
| 38 | Tekla Capital Management LLC | 41,400 | 3,783,000 | 0.28% | Call | |
| 39 | Iguana Healthcare Management, LLC | 40,000 | 3,655,000 | 0.27% | ||
| 40 | GOLDMAN SACHS GROUP INC | 37,400 | 3,417,000 | 0.25% | Call | |
| 41 | MILLENNIUM MANAGEMENT LLC | 30,316 | 2,770,000 | 0.20% | ||
| 42 | Ghost Tree Capital, LLC | 30,000 | 2,741,000 | 0.20% | ||
| 43 | CITADEL ADVISORS LLC | 28,369 | 2,592,000 | 0.19% | ||
| 44 | AMERIPRISE FINANCIAL INC | 28,192 | 2,575,000 | 0.19% | ||
| 45 | CITIGROUP INC | 26,400 | 2,412,000 | 0.18% | Put | |
| 46 | ASCEND CAPITAL, LLC | 24,960 | 2,281,000 | 0.17% | ||
| 47 | D. E. Shaw & Co., Inc. | 23,800 | 2,175,000 | 0.16% | Call | |
| 48 | D. E. Shaw & Co., Inc. | 22,731 | 2,077,000 | 0.15% | ||
| 49 | A.R.T. Advisors, LLC | 22,201 | 2,028,000 | 0.15% | ||
| 50 | Nationwide Fund Advisors | 22,000 | 2,010,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
