| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 2,051,274 | 186,933,000 | 18.42% | ||
| 2 | FMR LLC | 1,686,135 | 153,657,000 | 15.14% | ||
| 3 | Bank of New York Mellon Corp | 682,523 | 62,198,000 | 6.13% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 554,749 | 50,554,000 | 4.98% | ||
| 5 | PRUDENTIAL PLC | 530,000 | 48,299,000 | 4.76% | ||
| 6 | FEDERATED HERMES, INC. | 504,200 | 45,948,000 | 4.53% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 453,280 | 41,307,000 | 4.07% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 363,700 | 33,144,000 | 3.27% | ||
| 9 | Capital World Investors | 350,100 | 31,905,000 | 3.14% | ||
| 10 | BANK OF AMERICA CORP /DE/ | 328,373 | 29,925,000 | 2.95% | ||
| 11 | VHCP Management, LLC | 311,853 | 28,419,000 | 2.80% | ||
| 12 | WELLS FARGO & COMPANY/MN | 306,574 | 27,937,000 | 2.75% | ||
| 13 | JENNISON ASSOCIATES LLC | 304,196 | 27,721,000 | 2.73% | ||
| 14 | MANAGED ACCOUNT ADVISORS LLC | 278,254 | 25,357,000 | 2.50% | ||
| 15 | FRANKLIN RESOURCES INC | 235,270 | 21,440,000 | 2.11% | ||
| 16 | CLOUGH CAPITAL PARTNERS L P | 232,200 | 21,160,000 | 2.08% | ||
| 17 | ORBIMED ADVISORS LLC | 202,000 | 18,408,000 | 1.81% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 181,900 | 16,577,000 | 1.63% | Call | |
| 19 | Lamond Capital Partners LLC | 171,496 | 15,628,000 | 1.54% | ||
| 20 | BlackRock Fund Advisors | 146,982 | 13,394,000 | 1.32% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 127,500 | 11,619,000 | 1.14% | Put | |
| 22 | Redmile Group, LLC | 119,114 | 10,855,000 | 1.07% | ||
| 23 | Fiera Capital Corp | 88,800 | 8,092,000 | 0.80% | ||
| 24 | Asset Management One Co., Ltd. | 80,649 | 7,129,000 | 0.70% | ||
| 25 | MORGAN STANLEY | 72,555 | 6,612,000 | 0.65% | ||
| 26 | Rock Springs Capital Management LP | 70,000 | 6,379,000 | 0.63% | ||
| 27 | SABBY MANAGEMENT, LLC | 52,776 | 4,809,000 | 0.47% | ||
| 28 | Iguana Healthcare Management, LLC | 50,000 | 4,557,000 | 0.45% | ||
| 29 | PEAK6 Group LLC | 48,800 | 4,447,000 | 0.44% | Call | |
| 30 | Ghost Tree Capital, LLC | 45,000 | 4,101,000 | 0.40% | ||
| 31 | SPHERA FUNDS MANAGEMENT LTD. | 35,000 | 3,190,000 | 0.31% | ||
| 32 | EVENTIDE ASSET MANAGEMENT, LLC | 33,500 | 3,053,000 | 0.30% | ||
| 33 | CHESAPEAKE PARTNERS MANAGEMENT CO INC/MD | 30,000 | 2,734,000 | 0.27% | ||
| 34 | JPMORGAN CHASE & CO | 29,007 | 2,643,000 | 0.26% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 26,020 | 2,371,000 | 0.23% | ||
| 36 | MOORE CAPITAL MANAGEMENT, LP | 25,000 | 2,278,000 | 0.22% | ||
| 37 | Nationwide Fund Advisors | 24,900 | 2,269,000 | 0.22% | ||
| 38 | Advisors Asset Management, Inc. | 23,154 | 2,110,000 | 0.21% | ||
| 39 | CREDIT SUISSE AG/ | 21,606 | 1,969,000 | 0.19% | ||
| 40 | PDT Partners, LLC | 21,500 | 1,959,000 | 0.19% | ||
| 41 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 20,679 | 1,884,000 | 0.19% | ||
| 42 | CITIGROUP INC | 17,900 | 1,631,000 | 0.16% | Put | |
| 43 | D. E. Shaw & Co., Inc. | 17,700 | 1,613,000 | 0.16% | Put | |
| 44 | Sigma Planning Corp | 13,127 | 1,196,000 | 0.12% | ||
| 45 | D. E. Shaw & Co., Inc. | 12,300 | 1,121,000 | 0.11% | Call | |
| 46 | PEAK6 Group LLC | 10,500 | 957,000 | 0.09% | Put | |
| 47 | D. E. Shaw & Co., Inc. | 9,729 | 887,000 | 0.09% | ||
| 48 | CITIGROUP INC | 9,500 | 866,000 | 0.09% | Call | |
| 49 | ProShare Advisors LLC | 9,497 | 865,000 | 0.09% | ||
| 50 | A.R.T. Advisors, LLC | 9,286 | 846,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
