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Institutional Investment Manager
RA CAPITAL MANAGEMENT, L.P.
RA CAPITAL MANAGEMENT, L.P. (CIK: 0001346824) incorporated in Delaware, located at 200 Berkeley Street, 18th Floor, Boston, MA. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q3)
Portfolio Summary: 30 holdings with a total value of $969,369,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 WAVE LIFE SCIENCES LTD 7,088,651 230,168,000 23.74%
2 ACHILLION PHARMACEUTICALS INC COM 12,033,220 97,469,000 10.05%
3 Ascendis Pharma 3,681,491 73,998,000 7.63%
4 AVEXIS INC COM 1,732,274 71,387,000 7.36%
5 AXOVANT SCIENCES LTD 5,000,000 70,000,000 7.22%
6 NEKTAR THERAPEUTICS COM 3,664,154 62,950,000 6.49%
7 ARDELYX INC COM 3,266,045 42,263,000 4.36%
8 ACLARIS THERAPEUTICS INC COM 1,547,152 39,623,000 4.09%
9 TG THERAPEUTICS INC COM 4,631,114 35,845,000 3.70%
10 ZOGENIX INC 2,656,166 31,451,000 3.24%
11 Aquinox Pharmaceuticals Inc 2,191,977 29,285,000 3.02%
12 AIMMUNE THERAPEUTICS INC COM 1,292,940 19,394,000 2.00%
13 Foamix Pharmaceuticals Ltd. 1,820,138 16,854,000 1.74%
14 Protagonist Therapeutics, Inc. 754,411 15,941,000 1.64%
15 Proteon Therapeutics 1,626,931 15,179,000 1.57%
16 Dicerna Pharmaceuticals 2,428,571 14,280,000 1.47%
17 BIOCRYST PHARMACEUTICALS 2,989,795 13,185,000 1.36%
18 Strongbridge Biopharma plc 2,501,667 13,059,000 1.35%
19 Audentes Therapeutics, Inc. 707,426 12,599,000 1.30%
20 DIMENSION THERAPEUTICS INC COM 1,548,033 12,369,000 1.28%
21 ACCELERON PHARMA 318,565 11,529,000 1.19%
22 ARROWHEAD PHARMACEUTICALS IN 1,525,424 11,212,000 1.16%
23 TENAX THERAPEUTICS INC COM 2,389,700 5,532,000 0.57%
24 BEIGENE LTD 170,000 5,238,000 0.54%
25 ALCOBRA LTD 2,044,756 5,051,000 0.52%
26 EIGER BIOPHARMACEUTICALS INC 354,200 4,743,000 0.49%
27 SANGAMO BIOSCIENCES INCORPORATED 899,438 4,164,000 0.43%
28 AEGLEA BIOTHERAPEUTICS INC COM 336,134 2,155,000 0.22%
29 ARCA BIOPHARMA INCORPORATED COM PAR .001 521,606 1,476,000 0.15%
30 AKARI THERAPEUTICS PLC 114,039 970,000 0.10%

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-134325, filed 2016.11.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.