| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 3,370,306 | 17,458,000 | 18.49% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,100,000 | 10,878,000 | 11.52% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,720,838 | 8,914,000 | 9.44% | ||
| 4 | Opaleye Management Inc. | 1,500,000 | 7,770,000 | 8.23% | ||
| 5 | VANGUARD GROUP INC | 1,155,752 | 5,987,000 | 6.34% | ||
| 6 | BlackRock Fund Advisors | 886,435 | 4,592,000 | 4.86% | ||
| 7 | BAKER BROS. ADVISORS LP | 880,539 | 4,561,000 | 4.83% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 760,167 | 3,938,000 | 4.17% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 648,053 | 3,357,000 | 3.56% | ||
| 10 | DLD ASSET MANAGEMENT, LP | 555,000 | 2,880,000 | 3.05% | Call | |
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 450,000 | 2,331,000 | 2.47% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 376,600 | 1,951,000 | 2.07% | Call | |
| 13 | CASDIN CAPITAL, LLC | 375,000 | 1,943,000 | 2.06% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 362,700 | 1,879,000 | 1.99% | ||
| 15 | STATE STREET CORP | 345,698 | 1,789,000 | 1.89% | ||
| 16 | NORTHERN TRUST CORP | 299,277 | 1,550,000 | 1.64% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 293,460 | 1,520,000 | 1.61% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 209,910 | 1,087,000 | 1.15% | ||
| 19 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 187,500 | 971,000 | 1.03% | ||
| 20 | Parallax Volatility Advisers, L.P. | 166,900 | 865,000 | 0.92% | Call | |
| 21 | SABBY MANAGEMENT, LLC | 138,195 | 716,000 | 0.76% | ||
| 22 | Bank of New York Mellon Corp | 112,637 | 583,000 | 0.62% | ||
| 23 | BlackRock Investment Management, LLC | 96,621 | 500,000 | 0.53% | ||
| 24 | MORGAN STANLEY | 84,870 | 440,000 | 0.47% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 83,753 | 434,000 | 0.46% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,836 | 357,000 | 0.38% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,992 | 290,000 | 0.31% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 51,000 | 264,000 | 0.28% | ||
| 29 | Birchview Capital, LP | 48,000 | 249,000 | 0.26% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 47,995 | 249,000 | 0.26% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,012 | 228,000 | 0.24% | ||
| 32 | TFS CAPITAL LLC | 43,622 | 226,000 | 0.24% | ||
| 33 | LPL Financial LLC | 39,126 | 213,000 | 0.23% | ||
| 34 | WORTH VENTURE PARTNERS, LLC | 119,000 | 211,000 | 0.22% | Call | |
| 35 | DLD ASSET MANAGEMENT, LP | 39,900 | 207,000 | 0.22% | Put | |
| 36 | TEACHERS ADVISORS, LLC | 39,332 | 204,000 | 0.22% | ||
| 37 | NORTHERN CAPITAL MANAGEMENT LLC | 35,950 | 186,000 | 0.20% | ||
| 38 | CARL DOMINO INC | 33,273 | 172,000 | 0.18% | ||
| 39 | Squarepoint Ops LLC | 31,152 | 161,000 | 0.17% | ||
| 40 | CITADEL ADVISORS LLC | 28,081 | 145,000 | 0.15% | ||
| 41 | CITADEL ADVISORS LLC | 27,200 | 141,000 | 0.15% | Call | |
| 42 | RHUMBLINE ADVISERS | 26,911 | 139,000 | 0.15% | ||
| 43 | JPMORGAN CHASE & CO | 24,863 | 129,000 | 0.14% | ||
| 44 | MASSEY QUICK SIMON & CO., LLC | 24,390 | 126,000 | 0.13% | ||
| 45 | WELLS FARGO & COMPANY/MN | 23,054 | 119,000 | 0.13% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,422 | 111,000 | 0.12% | ||
| 47 | WHITE PINE CAPITAL LLC | 20,000 | 104,000 | 0.11% | ||
| 48 | GOLDMAN SACHS GROUP INC | 18,178 | 94,000 | 0.10% | ||
| 49 | Nationwide Fund Advisors | 17,399 | 90,000 | 0.10% | ||
| 50 | BLACKROCK ADVISORS LLC | 16,692 | 86,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
