| 1 |
EcoR1 Capital, LLC |
1,986,413 |
5,860,000 |
32.93% |
|
|
| 2 |
Cormorant Asset Management, LP |
1,262,835 |
3,725,000 |
20.93% |
|
|
| 3 |
BlackRock Institutional Trust Company, N.A. |
801,249 |
2,364,000 |
13.28% |
|
|
| 4 |
PERCEPTIVE ADVISORS LLC |
615,844 |
1,811,000 |
10.18% |
|
|
| 5 |
SPHERA FUNDS MANAGEMENT LTD. |
528,325 |
1,559,000 |
8.76% |
|
|
| 6 |
VANGUARD GROUP INC |
160,595 |
472,000 |
2.65% |
|
|
| 7 |
ACUTA CAPITAL PARTNERS, LLC |
154,508 |
456,000 |
2.56% |
|
|
| 8 |
DAFNA Capital Management LLC |
100,000 |
295,000 |
1.66% |
|
SH |
| 9 |
JENNISON ASSOCIATES LLC |
98,368 |
289,000 |
1.62% |
|
|
| 10 |
GEODE CAPITAL MANAGEMENT, LLC |
64,739 |
190,000 |
1.07% |
|
|
| 11 |
Rotella Capital Management, Inc. |
42,600 |
126,000 |
0.71% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
34,600 |
102,000 |
0.57% |
|
|
| 13 |
GOLDMAN SACHS GROUP INC |
30,396 |
90,000 |
0.51% |
|
|
| 14 |
NORTHERN TRUST CORP |
26,030 |
77,000 |
0.43% |
|
|
| 15 |
ClariVest Asset Management LLC |
23,541 |
69,000 |
0.39% |
|
|
| 16 |
MORGAN STANLEY |
21,557 |
63,000 |
0.35% |
|
|
| 17 |
CITADEL ADVISORS LLC |
17,613 |
52,000 |
0.29% |
|
|
| 18 |
BlackRock Fund Advisors |
17,173 |
51,000 |
0.29% |
|
|
| 19 |
JBF Capital, Inc. |
11,800 |
35,000 |
0.20% |
|
|
| 20 |
Spark Investment Management LLC |
10,300 |
30,000 |
0.17% |
|
|
| 21 |
BLACKROCK ADVISORS LLC |
8,267 |
24,000 |
0.13% |
|
|
| 22 |
CITIGROUP INC |
8,092 |
24,000 |
0.13% |
|
|
| 23 |
UBS Group AG |
4,650 |
14,000 |
0.08% |
|
|
| 24 |
BlackRock Investment Management, LLC |
2,984 |
9,000 |
0.05% |
|
|
| 25 |
Tower Research Capital LLC (TRC) |
1,531 |
5,000 |
0.03% |
|
|
| 26 |
WELLS FARGO & COMPANY/MN |
1,000 |
3,000 |
0.02% |
|
|
| 27 |
BANK OF AMERICA CORP /DE/ |
500 |
1,000 |
0.01% |
|
|
| 28 |
BANK OF MONTREAL /CAN/ |
500 |
1,000 |
0.01% |
|
|
| 29 |
Apriem Advisors |
100 |
0 |
0.00% |
|
|
| 30 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
150 |
0 |
0.00% |
|
|
