| 1 |
Clarus Ventures, LLC |
4,644,705 |
29,633,000 |
68.29% |
|
|
| 2 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
301,801 |
1,929,000 |
4.45% |
|
|
| 3 |
SPHERA FUNDS MANAGEMENT LTD. |
200,000 |
1,276,000 |
2.94% |
|
|
| 4 |
First Washington CORP |
185,700 |
1,185,000 |
2.73% |
|
|
| 5 |
Nicholas Investment Partners, LP |
178,166 |
1,136,000 |
2.62% |
|
|
| 6 |
EMERALD ADVISERS, LLC |
175,000 |
1,117,000 |
2.57% |
|
|
| 7 |
Pine River Capital Management L.P. |
166,800 |
1,065,000 |
2.45% |
|
|
| 8 |
WELLINGTON MANAGEMENT GROUP LLP |
160,300 |
1,023,000 |
2.36% |
|
|
| 9 |
First Eagle Investment Management, LLC |
152,800 |
975,000 |
2.25% |
|
|
| 10 |
BlackRock Fund Advisors |
84,249 |
538,000 |
1.24% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
75,659 |
483,000 |
1.11% |
|
|
| 12 |
HighTower Advisors, LLC |
66,514 |
424,000 |
0.98% |
|
|
| 13 |
GOLDMAN SACHS GROUP INC |
52,066 |
332,000 |
0.77% |
|
|
| 14 |
SAC Capital Advisors LP |
39,182 |
250,000 |
0.58% |
|
|
| 15 |
Bank of New York Mellon Corp |
36,604 |
234,000 |
0.54% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
34,164 |
217,000 |
0.50% |
|
|
| 17 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,282 |
205,000 |
0.47% |
|
|
| 18 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
32,143 |
205,000 |
0.47% |
|
|
| 19 |
MORGAN STANLEY |
28,768 |
184,000 |
0.42% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
28,757 |
183,000 |
0.42% |
|
|
| 21 |
TFS CAPITAL LLC |
23,760 |
152,000 |
0.35% |
|
|
| 22 |
STATE STREET CORP |
22,700 |
145,000 |
0.33% |
|
|
| 23 |
DEUTSCHE BANK AG\ |
18,928 |
120,000 |
0.28% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
16,300 |
104,000 |
0.24% |
|
|
| 25 |
NORTHERN TRUST CORP |
15,050 |
96,000 |
0.22% |
|
|
| 26 |
BlackRock Investment Management, LLC |
8,180 |
52,000 |
0.12% |
|
|
| 27 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
6,500 |
41,000 |
0.09% |
|
|
| 28 |
BLACKROCK ADVISORS LLC |
6,088 |
39,000 |
0.09% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
3,640 |
23,000 |
0.05% |
|
|
| 30 |
MANAGED ACCOUNT ADVISORS LLC |
1,516 |
10,000 |
0.02% |
|
|
| 31 |
Nationwide Fund Advisors |
1,114 |
7,000 |
0.02% |
|
|
| 32 |
UBS AG |
1,100 |
7,000 |
0.02% |
|
|
| 33 |
BlackRock Japan Co. Ltd |
565 |
4,000 |
0.01% |
|
|
| 34 |
BANK OF AMERICA CORP /DE/ |
100 |
1,000 |
0.00% |
|
|
| 35 |
BARCLAYS PLC |
98 |
1,000 |
0.00% |
|
|
| 36 |
Tower Research Capital LLC (TRC) |
0 |
0 |
0.00% |
|
|
