| 1 |
Clarus Ventures, LLC |
4,644,705 |
27,357,000 |
72.51% |
|
|
| 2 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
286,801 |
1,669,000 |
4.42% |
|
|
| 3 |
Pine River Capital Management L.P. |
209,900 |
1,236,000 |
3.28% |
|
|
| 4 |
SPHERA FUNDS MANAGEMENT LTD. |
200,000 |
1,178,000 |
3.12% |
|
|
| 5 |
First Washington CORP |
194,440 |
1,145,000 |
3.03% |
|
|
| 6 |
EMERALD ADVISERS, LLC |
175,000 |
1,031,000 |
2.73% |
|
|
| 7 |
WELLINGTON MANAGEMENT GROUP LLP |
160,300 |
944,000 |
2.50% |
|
|
| 8 |
First Eagle Investment Management, LLC |
114,456 |
674,000 |
1.79% |
|
|
| 9 |
Alyeska Investment Group, L.P. |
82,943 |
489,000 |
1.30% |
|
|
| 10 |
HighTower Advisors, LLC |
66,514 |
392,000 |
1.04% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
37,853 |
223,000 |
0.59% |
|
|
| 12 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
35,900 |
211,000 |
0.56% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
32,104 |
189,000 |
0.50% |
|
|
| 14 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
32,143 |
189,000 |
0.50% |
|
|
| 15 |
MORGAN STANLEY |
31,083 |
184,000 |
0.49% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
20,903 |
123,000 |
0.33% |
|
|
| 17 |
TFS CAPITAL LLC |
19,147 |
113,000 |
0.30% |
|
|
| 18 |
Paloma Partners Management Co |
15,379 |
91,000 |
0.24% |
|
|
| 19 |
NORTHERN TRUST CORP |
15,399 |
90,000 |
0.24% |
|
|
| 20 |
BANK OF AMERICA CORP /DE/ |
14,222 |
84,000 |
0.22% |
|
|
| 21 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
10,261 |
60,000 |
0.16% |
|
|
| 22 |
GLENMEDE TRUST CO NA |
3,925 |
23,000 |
0.06% |
|
|
| 23 |
UBS AG |
2,900 |
17,000 |
0.05% |
|
|
| 24 |
BARCLAYS PLC |
2,290 |
11,000 |
0.03% |
|
|
| 25 |
BlackRock Investment Management, LLC |
668 |
4,000 |
0.01% |
|
|
| 26 |
BNP PARIBAS FINANCIAL MARKETS |
383 |
2,256 |
0.01% |
|
|
| 27 |
BANK OF MONTREAL /CAN/ |
90 |
1,000 |
0.00% |
|
|
| 28 |
ROYAL BANK OF CANADA |
64 |
0 |
0.00% |
|
|
