| 1 |
Clarus Ventures, LLC |
4,644,705 |
20,345,000 |
71.78% |
|
|
| 2 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
263,827 |
1,156,000 |
4.08% |
|
|
| 3 |
First Washington CORP |
188,850 |
827,000 |
2.92% |
|
|
| 4 |
EMERALD ADVISERS, LLC |
163,540 |
662,000 |
2.34% |
|
|
| 5 |
VANGUARD GROUP INC |
132,315 |
580,000 |
2.05% |
|
|
| 6 |
WELLINGTON MANAGEMENT GROUP LLP |
131,490 |
576,000 |
2.03% |
|
|
| 7 |
Point72 Asset Management, L.P. |
125,559 |
550,000 |
1.94% |
|
|
| 8 |
First Eagle Investment Management, LLC |
114,456 |
501,000 |
1.77% |
|
|
| 9 |
Iguana Healthcare Management, LLC |
100,000 |
438,000 |
1.55% |
|
|
| 10 |
Alyeska Investment Group, L.P. |
82,429 |
361,000 |
1.27% |
|
|
| 11 |
PURA VIDA INVESTMENTS, LLC |
80,500 |
353,000 |
1.25% |
|
|
| 12 |
Catalyst Capital Advisors LLC |
70,000 |
307,000 |
1.08% |
|
|
| 13 |
HighTower Advisors, LLC |
61,514 |
269,000 |
0.95% |
|
|
| 14 |
MORGAN STANLEY |
52,353 |
229,000 |
0.81% |
|
|
| 15 |
WHITEBOX ADVISORS LLC |
49,800 |
218,000 |
0.77% |
|
|
| 16 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
35,900 |
205,000 |
0.72% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
42,936 |
188,000 |
0.66% |
|
|
| 18 |
GOLDMAN SACHS GROUP INC |
31,110 |
136,000 |
0.48% |
|
|
| 19 |
Virtu KCG Holdings LLC |
19,534 |
86,000 |
0.30% |
|
|
| 20 |
Nicholas Investment Partners, LP |
19,188 |
84,000 |
0.30% |
|
|
| 21 |
MYCIO WEALTH PARTNERS, LLC |
12,000 |
53,000 |
0.19% |
|
|
| 22 |
Bank of New York Mellon Corp |
12,068 |
53,000 |
0.19% |
|
|
| 23 |
NORTHERN TRUST CORP |
10,554 |
46,000 |
0.16% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
10,050 |
44,000 |
0.16% |
|
|
| 25 |
UBS Group AG |
7,967 |
35,000 |
0.12% |
|
|
| 26 |
GLENMEDE TRUST CO NA |
3,925 |
17,000 |
0.06% |
|
|
| 27 |
Burt Wealth Advisors |
2,625 |
10,000 |
0.04% |
|
|
| 28 |
WELLS FARGO & COMPANY/MN |
1,000 |
4,000 |
0.01% |
|
|
| 29 |
PNC FINANCIAL SERVICES GROUP, INC. |
1,000 |
4,000 |
0.01% |
|
|
| 30 |
BANK OF MONTREAL /CAN/ |
1,000 |
4,000 |
0.01% |
|
|
| 31 |
BlackRock Investment Management, LLC |
668 |
3,000 |
0.01% |
|
|
