| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,660,432 | 1,117,213,000 | 31.17% | ||
| 2 | Capital Research Global Investors | 4,044,761 | 423,891,000 | 11.83% | ||
| 3 | FMR LLC | 3,610,601 | 378,391,000 | 10.56% | ||
| 4 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 3,521,000 | 369,001,000 | 10.29% | ||
| 5 | VANGUARD GROUP INC | 1,240,381 | 129,992,000 | 3.63% | ||
| 6 | Capital World Investors | 943,698 | 98,900,000 | 2.76% | ||
| 7 | BB BIOTECH AG | 898,476 | 94,160,000 | 2.63% | ||
| 8 | BlackRock Fund Advisors | 866,311 | 90,789,000 | 2.53% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 778,106 | 81,546,000 | 2.28% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 590,125 | 61,845,000 | 1.73% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 543,916 | 57,002,000 | 1.59% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 516,445 | 54,123,000 | 1.51% | ||
| 13 | STATE STREET CORP | 511,726 | 53,628,000 | 1.50% | ||
| 14 | LORD, ABBETT & CO. LLC | 497,825 | 52,172,000 | 1.46% | ||
| 15 | Invesco Ltd. | 491,086 | 51,466,000 | 1.44% | ||
| 16 | COLUMBUS CIRCLE INVESTORS | 261,590 | 27,415,000 | 0.76% | ||
| 17 | NORTHERN TRUST CORP | 252,139 | 26,424,000 | 0.74% | ||
| 18 | NORGES BANK | 227,201 | 23,811,000 | 0.66% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 217,600 | 22,804,000 | 0.64% | Put | |
| 20 | ArrowMark Colorado Holdings LLC | 197,613 | 20,710,000 | 0.58% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 186,400 | 19,534,000 | 0.54% | Call | |
| 22 | PEAK6 Group LLC | 177,100 | 18,560,000 | 0.52% | Put | |
| 23 | FRED ALGER MANAGEMENT, LLC | 162,865 | 17,068,000 | 0.48% | ||
| 24 | AMERIPRISE FINANCIAL INC | 161,013 | 16,874,000 | 0.47% | ||
| 25 | AXA S.A. | 124,133 | 13,009,000 | 0.36% | ||
| 26 | GOLDMAN SACHS GROUP INC | 124,100 | 13,005,000 | 0.36% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 122,658 | 12,854,000 | 0.36% | ||
| 28 | PALISADE CAPITAL MANAGEMENT, LP | 120,779 | 12,658,000 | 0.35% | ||
| 29 | PICTET ASSET MANAGEMENT LTD | 119,200 | 12,492,000 | 0.35% | ||
| 30 | JPMORGAN CHASE & CO | 118,231 | 12,390,000 | 0.35% | ||
| 31 | LOOMIS SAYLES & CO L P | 113,189 | 11,862,000 | 0.33% | ||
| 32 | ORBIMED ADVISORS LLC | 111,100 | 11,643,000 | 0.32% | ||
| 33 | WELLINGTON MANAGEMENT GROUP LLP | 107,039 | 11,218,000 | 0.31% | ||
| 34 | Bank of New York Mellon Corp | 103,581 | 10,856,000 | 0.30% | ||
| 35 | Allianz Asset Management GmbH | 89,780 | 9,409,000 | 0.26% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 87,789 | 9,200,000 | 0.26% | ||
| 37 | Pier Capital, LLC | 83,493 | 8,750,000 | 0.24% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 67,000 | 7,022,000 | 0.20% | ||
| 39 | BlackRock Investment Management, LLC | 58,441 | 6,125,000 | 0.17% | ||
| 40 | PEAK6 Group LLC | 55,500 | 5,816,000 | 0.16% | Call | |
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 54,871 | 5,751,000 | 0.16% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 53,342 | 5,590,000 | 0.16% | ||
| 43 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 49,900 | 5,230,000 | 0.15% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,070 | 4,095,000 | 0.11% | ||
| 45 | MACQUARIE GROUP LTD | 37,624 | 3,943,000 | 0.11% | ||
| 46 | DRIEHAUS CAPITAL MANAGEMENT LLC | 32,198 | 3,374,000 | 0.09% | ||
| 47 | ProShare Advisors LLC | 30,472 | 3,193,000 | 0.09% | ||
| 48 | TEACHERS ADVISORS, LLC | 30,149 | 3,160,000 | 0.09% | ||
| 49 | GOLDMAN SACHS GROUP INC | 30,000 | 3,144,000 | 0.09% | Put | |
| 50 | GOLDMAN SACHS GROUP INC | 30,000 | 3,144,000 | 0.09% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
