| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,648,182 | 883,480,000 | 32.70% | ||
| 2 | Capital Research Global Investors | 4,034,637 | 334,754,000 | 12.39% | ||
| 3 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 3,093,000 | 256,626,000 | 9.50% | ||
| 4 | FMR LLC | 2,686,964 | 222,937,000 | 8.25% | ||
| 5 | VANGUARD GROUP INC | 1,063,652 | 88,251,000 | 3.27% | ||
| 6 | Capital World Investors | 1,028,398 | 85,326,000 | 3.16% | ||
| 7 | BB BIOTECH AG | 939,957 | 77,988,000 | 2.89% | ||
| 8 | BlackRock Fund Advisors | 897,356 | 74,454,000 | 2.76% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 830,580 | 68,913,000 | 2.55% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 582,309 | 48,314,000 | 1.79% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 535,911 | 44,465,000 | 1.65% | ||
| 12 | STATE STREET CORP | 521,767 | 43,286,000 | 1.60% | ||
| 13 | SECTORAL ASSET MANAGEMENT INC | 465,145 | 38,593,000 | 1.43% | ||
| 14 | Invesco Ltd. | 382,397 | 31,727,000 | 1.17% | ||
| 15 | LORD, ABBETT & CO. LLC | 353,685 | 29,345,000 | 1.09% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 317,678 | 26,358,000 | 0.98% | ||
| 17 | NORTHERN TRUST CORP | 256,345 | 21,269,000 | 0.79% | ||
| 18 | NORGES BANK | 227,201 | 18,851,000 | 0.70% | ||
| 19 | FRED ALGER MANAGEMENT, LLC | 211,402 | 17,540,000 | 0.65% | ||
| 20 | COLUMBUS CIRCLE INVESTORS | 186,304 | 15,458,000 | 0.57% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 160,600 | 13,325,000 | 0.49% | Put | |
| 22 | GOLDMAN SACHS GROUP INC | 134,694 | 11,175,000 | 0.41% | ||
| 23 | AMERIPRISE FINANCIAL INC | 131,784 | 10,934,000 | 0.40% | ||
| 24 | AXA S.A. | 128,061 | 10,625,000 | 0.39% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 127,500 | 10,578,000 | 0.39% | Call | |
| 26 | PEAK6 Group LLC | 116,900 | 9,699,000 | 0.36% | Put | |
| 27 | WELLS FARGO & COMPANY/MN | 113,583 | 9,423,000 | 0.35% | ||
| 28 | JPMORGAN CHASE & CO | 113,401 | 9,408,000 | 0.35% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 113,327 | 9,402,000 | 0.35% | ||
| 30 | ArrowMark Colorado Holdings LLC | 111,556 | 9,256,000 | 0.34% | ||
| 31 | ORBIMED ADVISORS LLC | 111,100 | 9,218,000 | 0.34% | ||
| 32 | Bank of New York Mellon Corp | 109,722 | 9,104,000 | 0.34% | ||
| 33 | WELLINGTON MANAGEMENT GROUP LLP | 107,069 | 8,884,000 | 0.33% | ||
| 34 | PICTET ASSET MANAGEMENT LTD | 92,600 | 7,683,000 | 0.28% | ||
| 35 | LOOMIS SAYLES & CO L P | 88,358 | 7,331,000 | 0.27% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 80,931 | 6,715,000 | 0.25% | ||
| 37 | D. E. Shaw & Co., Inc. | 80,084 | 6,645,000 | 0.25% | ||
| 38 | Pier Capital, LLC | 77,786 | 6,454,000 | 0.24% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 75,338 | 5,933,000 | 0.22% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 60,673 | 5,034,000 | 0.19% | ||
| 41 | Tourbillon Capital Partners, L.P. | 60,000 | 4,978,000 | 0.18% | ||
| 42 | BlackRock Investment Management, LLC | 56,949 | 4,725,000 | 0.17% | ||
| 43 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 54,709 | 4,539,000 | 0.17% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 53,051 | 4,402,000 | 0.16% | ||
| 45 | ASCEND CAPITAL, LLC | 48,202 | 3,999,000 | 0.15% | ||
| 46 | Nicholas Investment Partners, LP | 43,094 | 3,575,000 | 0.13% | ||
| 47 | ProShare Advisors LLC | 42,969 | 3,565,000 | 0.13% | ||
| 48 | DEUTSCHE BANK AG\ | 42,075 | 3,490,000 | 0.13% | ||
| 49 | Laurion Capital Management LP | 38,714 | 3,212,000 | 0.12% | ||
| 50 | MACQUARIE GROUP LTD | 37,624 | 3,122,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
