| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 11,660,432 | 1,137,242,000 | 28.64% | ||
| 2 | FMR LLC | 5,543,741 | 540,681,000 | 13.62% | ||
| 3 | Capital Research Global Investors | 4,527,358 | 441,553,000 | 11.12% | ||
| 4 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 3,245,542 | 316,538,000 | 7.97% | ||
| 5 | VANGUARD GROUP INC | 1,554,979 | 151,658,000 | 3.82% | ||
| 6 | Capital World Investors | 1,262,798 | 123,161,000 | 3.10% | ||
| 7 | BlackRock Fund Advisors | 1,058,768 | 103,262,000 | 2.60% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,037,935 | 101,230,000 | 2.55% | ||
| 9 | BB BIOTECH AG | 1,025,476 | 100,015,000 | 2.52% | ||
| 10 | WELLS FARGO & COMPANY/MN | 797,807 | 77,810,000 | 1.96% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 610,716 | 59,563,000 | 1.50% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 593,823 | 57,916,000 | 1.46% | ||
| 13 | STATE STREET CORP | 583,000 | 56,863,000 | 1.43% | ||
| 14 | JANUS HENDERSON INVESTORS US LLC | 572,037 | 55,791,000 | 1.41% | ||
| 15 | ALLIANCEBERNSTEIN L.P. | 492,190 | 48,003,000 | 1.21% | ||
| 16 | LORD, ABBETT & CO. LLC | 388,980 | 37,937,000 | 0.96% | ||
| 17 | EAGLE ASSET MANAGEMENT INC | 371,816 | 36,263,000 | 0.91% | ||
| 18 | SECTORAL ASSET MANAGEMENT INC | 365,684 | 35,665,000 | 0.90% | ||
| 19 | Invesco Ltd. | 364,160 | 35,517,000 | 0.89% | ||
| 20 | Alpha Wave Global, LP | 304,000 | 29,649,000 | 0.75% | Put | |
| 21 | JPMORGAN CHASE & CO | 286,447 | 27,938,000 | 0.70% | ||
| 22 | NORTHERN TRUST CORP | 266,963 | 26,038,000 | 0.66% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 244,500 | 23,846,000 | 0.60% | Put | |
| 24 | NORGES BANK | 201,582 | 19,660,000 | 0.50% | ||
| 25 | Tekla Capital Management LLC | 198,689 | 19,378,000 | 0.49% | ||
| 26 | BLACKROCK ADVISORS LLC | 187,036 | 18,241,000 | 0.46% | ||
| 27 | AXA S.A. | 176,224 | 17,187,000 | 0.43% | ||
| 28 | ArrowMark Colorado Holdings LLC | 161,970 | 15,797,000 | 0.40% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 158,319 | 15,440,000 | 0.39% | ||
| 30 | Allianz Asset Management GmbH | 148,775 | 14,510,000 | 0.37% | ||
| 31 | Bank of New York Mellon Corp | 124,767 | 12,168,000 | 0.31% | ||
| 32 | AMERIPRISE FINANCIAL INC | 116,228 | 11,336,000 | 0.29% | ||
| 33 | GOLDMAN SACHS GROUP INC | 114,476 | 11,165,000 | 0.28% | ||
| 34 | BARCLAYS PLC | 106,100 | 10,292,000 | 0.26% | Put | |
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 67,000 | 8,025,000 | 0.20% | ||
| 36 | GUGGENHEIM CAPITAL LLC | 81,971 | 7,995,000 | 0.20% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 79,147 | 7,719,000 | 0.19% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 74,869 | 7,302,000 | 0.18% | ||
| 39 | BlackRock Investment Management, LLC | 74,379 | 7,254,000 | 0.18% | ||
| 40 | Tekla Capital Management LLC | 71,000 | 6,925,000 | 0.17% | Call | |
| 41 | Pier Capital, LLC | 61,028 | 5,952,000 | 0.15% | ||
| 42 | MACQUARIE GROUP LTD | 60,556 | 5,906,000 | 0.15% | ||
| 43 | GOLDMAN SACHS GROUP INC | 60,000 | 5,852,000 | 0.15% | Call | |
| 44 | PICTET ASSET MANAGEMENT LTD | 60,475 | 5,561,000 | 0.14% | ||
| 45 | LMCG INVESTMENTS, LLC | 56,342 | 5,496,000 | 0.14% | ||
| 46 | Candriam S.C.A. | 55,000 | 5,365,000 | 0.14% | ||
| 47 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 51,000 | 4,974,000 | 0.13% | ||
| 48 | D. E. Shaw & Co., Inc. | 50,303 | 4,906,000 | 0.12% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,563 | 4,151,000 | 0.10% | ||
| 50 | Cormorant Asset Management, LP | 42,500 | 4,145,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
