| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,660,432 | 733,225,000 | 30.00% | ||
| 2 | Capital Research Global Investors | 4,062,772 | 279,437,000 | 11.43% | ||
| 3 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 3,927,006 | 270,099,000 | 11.05% | ||
| 4 | FMR LLC | 3,883,041 | 267,076,000 | 10.93% | ||
| 5 | VANGUARD GROUP INC | 1,294,021 | 89,002,000 | 3.64% | ||
| 6 | BB BIOTECH AG | 1,093,476 | 75,209,000 | 3.08% | ||
| 7 | Capital World Investors | 943,698 | 64,908,000 | 2.66% | ||
| 8 | BlackRock Fund Advisors | 868,703 | 59,749,000 | 2.44% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 823,488 | 56,640,000 | 2.32% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 602,345 | 41,429,000 | 1.70% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 593,209 | 40,801,000 | 1.67% | ||
| 12 | ALLIANCEBERNSTEIN L.P. | 584,409 | 40,196,000 | 1.64% | ||
| 13 | WELLS FARGO & COMPANY/MN | 578,260 | 39,773,000 | 1.63% | ||
| 14 | STATE STREET CORP | 570,042 | 39,210,000 | 1.60% | ||
| 15 | Invesco Ltd. | 463,824 | 31,902,000 | 1.31% | ||
| 16 | LORD, ABBETT & CO. LLC | 456,547 | 31,401,000 | 1.28% | ||
| 17 | NORTHERN TRUST CORP | 241,476 | 16,608,000 | 0.68% | ||
| 18 | Tekla Capital Management LLC | 223,020 | 15,339,000 | 0.63% | ||
| 19 | ArrowMark Colorado Holdings LLC | 221,169 | 15,212,000 | 0.62% | ||
| 20 | NORGES BANK | 190,589 | 13,108,000 | 0.54% | ||
| 21 | SABBY MANAGEMENT, LLC | 145,200 | 9,987,000 | 0.41% | ||
| 22 | AXA S.A. | 143,660 | 9,881,000 | 0.40% | ||
| 23 | FRED ALGER MANAGEMENT, LLC | 141,993 | 9,766,000 | 0.40% | ||
| 24 | AMERIPRISE FINANCIAL INC | 141,593 | 9,738,000 | 0.40% | ||
| 25 | EAGLE ASSET MANAGEMENT INC | 134,395 | 9,243,000 | 0.38% | ||
| 26 | Allianz Asset Management GmbH | 131,105 | 9,018,000 | 0.37% | ||
| 27 | GOLDMAN SACHS GROUP INC | 123,118 | 8,468,000 | 0.35% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 122,641 | 8,435,000 | 0.35% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,700 | 8,027,000 | 0.33% | Put | |
| 30 | JPMORGAN CHASE & CO | 116,431 | 8,008,000 | 0.33% | ||
| 31 | ORBIMED ADVISORS LLC | 111,100 | 7,641,000 | 0.31% | ||
| 32 | Bank of New York Mellon Corp | 110,087 | 7,572,000 | 0.31% | ||
| 33 | WELLINGTON MANAGEMENT GROUP LLP | 105,457 | 7,254,000 | 0.30% | ||
| 34 | Cormorant Asset Management, LP | 100,000 | 6,878,000 | 0.28% | ||
| 35 | ASCEND CAPITAL, LLC | 85,000 | 5,846,000 | 0.24% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 83,027 | 5,711,000 | 0.23% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 70,423 | 4,844,000 | 0.20% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 67,000 | 4,608,000 | 0.19% | ||
| 39 | GUGGENHEIM CAPITAL LLC | 65,548 | 4,508,000 | 0.18% | ||
| 40 | BlackRock Investment Management, LLC | 58,355 | 4,014,000 | 0.16% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 57,667 | 3,967,000 | 0.16% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,200 | 3,865,000 | 0.16% | Call | |
| 43 | MACQUARIE GROUP LTD | 51,000 | 3,508,000 | 0.14% | ||
| 44 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,700 | 3,281,000 | 0.13% | ||
| 45 | Asset Management One Co., Ltd. | 41,258 | 2,857,000 | 0.12% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,010 | 2,821,000 | 0.12% | ||
| 47 | PICTET ASSET MANAGEMENT LTD | 40,400 | 2,779,000 | 0.11% | ||
| 48 | Pier Capital, LLC | 39,646 | 2,727,000 | 0.11% | ||
| 49 | PARADIGM ASSET MANAGEMENT CO LLC | 33,200 | 2,283,496 | 0.09% | ||
| 50 | DEUTSCHE BANK AG\ | 31,461 | 2,163,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
