| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,660,432 | 989,182,000 | 27.65% | ||
| 2 | Capital Research Global Investors | 4,455,058 | 513,312,000 | 14.35% | ||
| 3 | FMR LLC | 4,584,091 | 425,357,000 | 11.89% | ||
| 4 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 3,847,094 | 356,972,000 | 9.98% | ||
| 5 | Capital World Investors | 1,222,698 | 140,879,000 | 3.94% | ||
| 6 | VANGUARD GROUP INC | 1,320,921 | 122,569,000 | 3.43% | ||
| 7 | BB BIOTECH AG | 1,130,476 | 104,897,000 | 2.93% | ||
| 8 | BlackRock Fund Advisors | 939,346 | 87,162,000 | 2.44% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 852,852 | 79,136,000 | 2.21% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 580,981 | 53,909,000 | 1.51% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 550,812 | 51,110,000 | 1.43% | ||
| 12 | STATE STREET CORP | 530,650 | 49,236,000 | 1.38% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 490,700 | 45,532,000 | 1.27% | ||
| 14 | Invesco Ltd. | 465,800 | 43,222,000 | 1.21% | ||
| 15 | WELLS FARGO & COMPANY/MN | 434,542 | 40,321,000 | 1.13% | ||
| 16 | LORD, ABBETT & CO. LLC | 433,042 | 40,182,000 | 1.12% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 363,884 | 33,765,000 | 0.94% | ||
| 18 | ArrowMark Colorado Holdings LLC | 239,660 | 22,238,000 | 0.62% | ||
| 19 | NORTHERN TRUST CORP | 233,084 | 21,628,000 | 0.60% | ||
| 20 | JPMORGAN CHASE & CO | 229,340 | 21,280,000 | 0.59% | ||
| 21 | Tekla Capital Management LLC | 223,020 | 20,694,000 | 0.58% | ||
| 22 | Allianz Asset Management GmbH | 211,645 | 19,639,000 | 0.55% | ||
| 23 | NORGES BANK | 205,265 | 19,046,000 | 0.53% | ||
| 24 | AXA S.A. | 150,727 | 13,986,000 | 0.39% | ||
| 25 | AMERIPRISE FINANCIAL INC | 141,773 | 13,155,000 | 0.37% | ||
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 137,587 | 12,766,000 | 0.36% | ||
| 27 | EAGLE ASSET MANAGEMENT INC | 132,345 | 12,280,000 | 0.34% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 127,652 | 11,844,000 | 0.33% | ||
| 29 | GOLDMAN SACHS GROUP INC | 113,279 | 10,511,000 | 0.29% | ||
| 30 | Bank of New York Mellon Corp | 111,185 | 10,316,000 | 0.29% | ||
| 31 | Cormorant Asset Management, LP | 100,000 | 9,279,000 | 0.26% | ||
| 32 | PICTET ASSET MANAGEMENT LTD | 96,493 | 8,954,000 | 0.25% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 88,058 | 8,171,000 | 0.23% | ||
| 34 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 67,000 | 8,025,000 | 0.22% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,400 | 7,646,000 | 0.21% | Put | |
| 36 | BLUE JAY CAPITAL MANAGEMENT, LLC | 80,000 | 7,423,000 | 0.21% | ||
| 37 | ORBIMED ADVISORS LLC | 77,800 | 7,219,000 | 0.20% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 75,200 | 6,978,000 | 0.20% | ||
| 39 | Asset Management One Co., Ltd. | 71,075 | 6,623,000 | 0.19% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 63,848 | 5,924,000 | 0.17% | ||
| 41 | BlackRock Investment Management, LLC | 58,122 | 5,393,000 | 0.15% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 57,917 | 5,375,000 | 0.15% | ||
| 43 | DEUTSCHE BANK AG\ | 51,640 | 4,791,000 | 0.13% | ||
| 44 | MACQUARIE GROUP LTD | 51,000 | 4,732,000 | 0.13% | ||
| 45 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,600 | 4,417,000 | 0.12% | ||
| 46 | Candriam S.C.A. | 40,000 | 3,712,000 | 0.10% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,863 | 3,699,000 | 0.10% | ||
| 48 | Pier Capital, LLC | 37,305 | 3,462,000 | 0.10% | ||
| 49 | GOLDMAN SACHS GROUP INC | 35,900 | 3,331,000 | 0.09% | Call | |
| 50 | GOLDMAN SACHS GROUP INC | 35,900 | 3,331,000 | 0.09% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
