| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 8,192,167 | 7,209,000 | 50.09% | ||
| 2 | WARBURG PINCUS LLC | 2,460,807 | 2,158,000 | 15.00% | ||
| 3 | MARXE AUSTIN W & GREENHOUSE DAVID M | 1,801,477 | 1,581,000 | 10.99% | ||
| 4 | SABBY MANAGEMENT, LLC | 1,695,700 | 1,488,000 | 10.34% | ||
| 5 | VANGUARD GROUP INC | 800,934 | 703,000 | 4.88% | ||
| 6 | Connective Capital Management, LLC | 712,753 | 625,000 | 4.34% | ||
| 7 | GABELLI FUNDS LLC | 220,000 | 193,000 | 1.34% | ||
| 8 | Virtu KCG Holdings LLC | 92,129 | 81,000 | 0.56% | ||
| 9 | RIVERHEAD CAPITAL MANAGEMENT LLC | 60,111 | 53,000 | 0.37% | ||
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 49,771 | 43,000 | 0.30% | ||
| 11 | BlackRock Fund Advisors | 43,966 | 39,000 | 0.27% | ||
| 12 | STATE STREET CORP | 38,739 | 34,000 | 0.24% | ||
| 13 | D. E. Shaw & Co., Inc. | 38,087 | 33,000 | 0.23% | ||
| 14 | Ulys, L.L.C. | 31,131 | 27,000 | 0.19% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 27,828 | 24,000 | 0.17% | ||
| 16 | CITADEL ADVISORS LLC | 20,967 | 18,000 | 0.13% | ||
| 17 | NORTHERN TRUST CORP | 18,150 | 16,000 | 0.11% | ||
| 18 | GOFEN & GLOSSBERG LLC /IL/ | 10,000 | 14,000 | 0.10% | ||
| 19 | CREDIT SUISSE AG/ | 15,920 | 14,000 | 0.10% | ||
| 20 | HSBC HOLDINGS PLC | 14,024 | 12,000 | 0.08% | ||
| 21 | GUGGENHEIM CAPITAL LLC | 10,124 | 9,000 | 0.06% | ||
| 22 | COBIZ WEALTH, LLC | 10,666 | 9,000 | 0.06% | ||
| 23 | MORGAN STANLEY | 6,102 | 5,000 | 0.03% | ||
| 24 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 769 | 1,000 | 0.01% | ||
| 25 | ALLIANCEBERNSTEIN L.P. | 1,558 | 1,000 | 0.01% | ||
| 26 | Creative Planning | 1,000 | 1,000 | 0.01% | ||
| 27 | BNP PARIBAS FINANCIAL MARKETS | 494 | 306 | 0.00% | ||
| 28 | ROYAL BANK OF CANADA | 8 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
