| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 8,192,167 | 5,489,000 | 60.96% | ||
| 2 | WARBURG PINCUS LLC | 2,460,807 | 1,649,000 | 18.31% | ||
| 3 | SABBY MANAGEMENT, LLC | 1,484,866 | 989,000 | 10.98% | ||
| 4 | VANGUARD GROUP INC | 800,934 | 534,000 | 5.93% | ||
| 5 | GABELLI FUNDS LLC | 170,000 | 113,000 | 1.25% | ||
| 6 | RENAISSANCE TECHNOLOGIES LLC | 102,500 | 68,000 | 0.76% | ||
| 7 | D. E. Shaw & Co., Inc. | 55,688 | 37,000 | 0.41% | ||
| 8 | GEODE CAPITAL MANAGEMENT, LLC | 49,715 | 33,000 | 0.37% | ||
| 9 | Ulys, L.L.C. | 31,131 | 21,000 | 0.23% | ||
| 10 | CITADEL ADVISORS LLC | 24,661 | 16,000 | 0.18% | ||
| 11 | NORTHERN TRUST CORP | 18,150 | 12,000 | 0.13% | ||
| 12 | GUGGENHEIM CAPITAL LLC | 17,252 | 11,000 | 0.12% | ||
| 13 | HSBC HOLDINGS PLC | 14,024 | 9,000 | 0.10% | ||
| 14 | GOFEN & GLOSSBERG LLC /IL/ | 10,000 | 7,000 | 0.08% | ||
| 15 | COBIZ WEALTH, LLC | 10,666 | 7,000 | 0.08% | ||
| 16 | MORGAN STANLEY | 5,581 | 3,000 | 0.03% | ||
| 17 | Tower Research Capital LLC (TRC) | 3,515 | 2,000 | 0.02% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 1,231 | 1,000 | 0.01% | ||
| 19 | CITIGROUP INC | 934 | 1,000 | 0.01% | ||
| 20 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 769 | 1,000 | 0.01% | ||
| 21 | Creative Planning | 2,000 | 1,000 | 0.01% | ||
| 22 | BNP PARIBAS FINANCIAL MARKETS | 494 | 331 | 0.00% | ||
| 23 | D.A. DAVIDSON & CO. | 1,000 | 0 | 0.00% | ||
| 24 | DEUTSCHE BANK AG\ | 378 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
