| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 8,192,167 | 3,359,000 | 56.53% | ||
| 2 | WARBURG PINCUS LLC | 2,460,807 | 1,009,000 | 16.98% | ||
| 3 | MARXE AUSTIN W & GREENHOUSE DAVID M | 1,614,032 | 662,000 | 11.14% | ||
| 4 | VANGUARD GROUP INC | 855,777 | 351,000 | 5.91% | ||
| 5 | SABBY MANAGEMENT, LLC | 500,000 | 205,000 | 3.45% | ||
| 6 | RENAISSANCE TECHNOLOGIES LLC | 234,700 | 96,000 | 1.62% | ||
| 7 | GABELLI FUNDS LLC | 150,000 | 62,000 | 1.04% | ||
| 8 | Virtu KCG Holdings LLC | 118,283 | 48,000 | 0.81% | ||
| 9 | ESSEX INVESTMENT MANAGEMENT CO LLC | 79,638 | 33,000 | 0.56% | ||
| 10 | D. E. Shaw & Co., Inc. | 55,688 | 23,000 | 0.39% | ||
| 11 | CITADEL ADVISORS LLC | 48,808 | 20,000 | 0.34% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 49,827 | 20,000 | 0.34% | ||
| 13 | Ulys, L.L.C. | 31,131 | 13,000 | 0.22% | ||
| 14 | GOLDMAN SACHS GROUP INC | 18,352 | 8,000 | 0.13% | ||
| 15 | NORTHERN TRUST CORP | 18,150 | 7,000 | 0.12% | ||
| 16 | Tower Research Capital LLC (TRC) | 14,727 | 6,000 | 0.10% | ||
| 17 | HSBC HOLDINGS PLC | 14,024 | 6,000 | 0.10% | ||
| 18 | GOFEN & GLOSSBERG LLC /IL/ | 10,000 | 4,000 | 0.07% | ||
| 19 | COBIZ WEALTH, LLC | 10,666 | 4,000 | 0.07% | ||
| 20 | UBS AG | 6,359 | 3,000 | 0.05% | ||
| 21 | MORGAN STANLEY | 5,200 | 2,000 | 0.03% | ||
| 22 | Creative Planning | 2,000 | 1,000 | 0.02% | ||
| 23 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 769 | 0 | 0.00% | ||
| 24 | D.A. DAVIDSON & CO. | 1,000 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
