| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 9,275,565 | 81,625,000 | 10.94% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 8,690,700 | 76,478,000 | 10.25% | ||
| 3 | KORNITZER CAPITAL MANAGEMENT INC /KS | 5,029,725 | 44,262,000 | 5.93% | ||
| 4 | VANGUARD GROUP INC | 4,532,762 | 39,888,000 | 5.35% | ||
| 5 | ORACLE INVESTMENT MANAGEMENT INC | 3,616,293 | 31,823,378 | 4.27% | ||
| 6 | BRIDGER MANAGEMENT, LLC | 3,000,000 | 26,400,000 | 3.54% | ||
| 7 | Boston Partners | 2,432,860 | 21,409,000 | 2.87% | ||
| 8 | Lapides Asset Management, LLC | 2,339,600 | 20,588,000 | 2.76% | ||
| 9 | BlackRock Fund Advisors | 2,131,309 | 18,756,000 | 2.51% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,131,270 | 18,755,000 | 2.51% | ||
| 11 | Redmile Group, LLC | 1,866,260 | 16,423,000 | 2.20% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,861,569 | 16,382,000 | 2.20% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,832,293 | 16,124,000 | 2.16% | ||
| 14 | ROYCE & ASSOCIATES LP | 1,690,500 | 14,876,000 | 1.99% | ||
| 15 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 1,542,100 | 13,570,000 | 1.82% | ||
| 16 | HEARTLAND ADVISORS INC | 1,500,000 | 13,200,000 | 1.77% | ||
| 17 | DECADE CAPITAL MANAGEMENT LLC | 1,449,325 | 12,754,000 | 1.71% | ||
| 18 | DIMENSIONAL FUND ADVISORS LP | 1,362,417 | 11,990,000 | 1.61% | ||
| 19 | STATE STREET CORP | 1,269,412 | 11,173,000 | 1.50% | ||
| 20 | March Altus Capital Management LP | 1,102,494 | 9,702,000 | 1.30% | ||
| 21 | THB ASSET MANAGEMENT | 1,056,320 | 9,295,000 | 1.25% | ||
| 22 | APG Asset Management N.V. | 1,050,000 | 9,240,000 | 1.24% | ||
| 23 | Point72 Asset Management, L.P. | 1,028,900 | 9,054,000 | 1.21% | ||
| 24 | NORTH TIDE CAPITAL, LLC | 1,000,000 | 8,800,000 | 1.18% | ||
| 25 | Visium Asset Management, LP | 1,000,000 | 8,800,000 | 1.18% | ||
| 26 | GOLDMAN SACHS GROUP INC | 941,600 | 8,286,000 | 1.11% | Put | |
| 27 | NORTHERN TRUST CORP | 911,883 | 8,026,000 | 1.08% | ||
| 28 | Phocas Financial Corp. | 878,172 | 7,728,000 | 1.04% | SH | |
| 29 | WELLS FARGO & COMPANY/MN | 865,211 | 7,614,000 | 1.02% | ||
| 30 | ArrowMark Colorado Holdings LLC | 844,600 | 7,432,000 | 1.00% | ||
| 31 | PRICE T ROWE ASSOCIATES INC /MD/ | 832,720 | 7,328,000 | 0.98% | ||
| 32 | Tekla Capital Management LLC | 731,943 | 6,441,000 | 0.86% | ||
| 33 | Neuberger Berman Group LLC | 730,733 | 6,430,000 | 0.86% | ||
| 34 | CITADEL ADVISORS LLC | 685,114 | 6,029,000 | 0.81% | ||
| 35 | GOLDMAN SACHS GROUP INC | 676,800 | 5,956,000 | 0.80% | Call | |
| 36 | WHV Investments, Inc. | 596,788 | 5,252,000 | 0.70% | ||
| 37 | RENAISSANCE TECHNOLOGIES LLC | 529,123 | 4,656,000 | 0.62% | ||
| 38 | SECTORAL ASSET MANAGEMENT INC | 491,505 | 4,325,000 | 0.58% | ||
| 39 | Elk Creek Partners, LLC | 485,865 | 4,276,000 | 0.57% | ||
| 40 | FULLER & THALER ASSET MANAGEMENT, INC. | 454,600 | 4,000,000 | 0.54% | ||
| 41 | BALYASNY ASSET MANAGEMENT L.P. | 442,467 | 3,894,000 | 0.52% | ||
| 42 | Bank of New York Mellon Corp | 432,356 | 3,806,000 | 0.51% | ||
| 43 | D. E. Shaw & Co., Inc. | 414,390 | 3,647,000 | 0.49% | ||
| 44 | GEODE CAPITAL MANAGEMENT, LLC | 400,279 | 3,521,000 | 0.47% | ||
| 45 | GOLDMAN SACHS GROUP INC | 380,601 | 3,349,000 | 0.45% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 292,261 | 2,572,000 | 0.34% | ||
| 47 | NORGES BANK | 282,414 | 2,485,000 | 0.33% | ||
| 48 | MORGAN STANLEY | 268,650 | 2,364,000 | 0.32% | ||
| 49 | KENNEDY CAPITAL MANAGEMENT LLC | 260,651 | 2,294,000 | 0.31% | ||
| 50 | Ghost Tree Capital, LLC | 250,000 | 2,200,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
