| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 8,665,700 | 65,426,000 | 9.72% | ||
| 2 | FMR LLC | 5,232,300 | 39,504,000 | 5.87% | ||
| 3 | VANGUARD GROUP INC | 4,656,341 | 35,155,000 | 5.23% | ||
| 4 | KORNITZER CAPITAL MANAGEMENT INC /KS | 4,585,490 | 34,620,000 | 5.15% | ||
| 5 | BRIDGER MANAGEMENT, LLC | 3,787,260 | 28,594,000 | 4.25% | ||
| 6 | ORACLE INVESTMENT MANAGEMENT INC | 3,657,700 | 27,616,000 | 4.10% | ||
| 7 | JPMORGAN CHASE & CO | 3,251,652 | 24,550,000 | 3.65% | ||
| 8 | Boston Partners | 3,046,920 | 23,004,000 | 3.42% | ||
| 9 | Lapides Asset Management, LLC | 2,735,000 | 20,649,000 | 3.07% | ||
| 10 | BlackRock Fund Advisors | 2,427,905 | 18,331,000 | 2.72% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,274,013 | 17,169,000 | 2.55% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 2,262,281 | 17,080,000 | 2.54% | ||
| 13 | CLOUGH CAPITAL PARTNERS L P | 2,080,600 | 15,709,000 | 2.33% | ||
| 14 | NORTH TIDE CAPITAL, LLC | 2,000,000 | 15,100,000 | 2.24% | ||
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,953,209 | 14,747,000 | 2.19% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,870,943 | 14,126,000 | 2.10% | ||
| 17 | ROYCE & ASSOCIATES LP | 1,713,000 | 12,933,000 | 1.92% | ||
| 18 | BLACKROCK ADVISORS LLC | 1,556,356 | 11,750,000 | 1.75% | ||
| 19 | Redmile Group, LLC | 1,535,475 | 11,593,000 | 1.72% | ||
| 20 | HEARTLAND ADVISORS INC | 1,500,000 | 11,325,000 | 1.68% | ||
| 21 | DECADE CAPITAL MANAGEMENT LLC | 1,466,131 | 11,069,000 | 1.65% | ||
| 22 | THB ASSET MANAGEMENT | 1,458,510 | 11,011,000 | 1.64% | ||
| 23 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,325,000 | 10,004,000 | 1.49% | ||
| 24 | STATE STREET CORP | 1,288,761 | 9,728,000 | 1.45% | ||
| 25 | BALYASNY ASSET MANAGEMENT L.P. | 1,261,819 | 9,527,000 | 1.42% | ||
| 26 | Neuberger Berman Group LLC | 1,242,590 | 9,381,000 | 1.39% | ||
| 27 | D. E. Shaw & Co., Inc. | 1,116,740 | 8,432,000 | 1.25% | ||
| 28 | NORGES BANK | 1,062,339 | 8,020,000 | 1.19% | ||
| 29 | RENAISSANCE TECHNOLOGIES LLC | 992,983 | 7,497,000 | 1.11% | ||
| 30 | WELLS FARGO & COMPANY/MN | 979,806 | 7,398,000 | 1.10% | ||
| 31 | Elk Creek Partners, LLC | 974,663 | 7,359,000 | 1.09% | ||
| 32 | Point72 Asset Management, L.P. | 952,100 | 7,188,000 | 1.07% | ||
| 33 | NORTHERN TRUST CORP | 862,254 | 6,510,000 | 0.97% | ||
| 34 | PFM Health Sciences, LP | 834,285 | 6,299,000 | 0.94% | ||
| 35 | Tekla Capital Management LLC | 731,943 | 5,526,000 | 0.82% | ||
| 36 | Phocas Financial Corp. | 718,275 | 5,423,000 | 0.81% | SH | |
| 37 | Broadfin Capital, LLC | 700,000 | 5,285,000 | 0.79% | ||
| 38 | KENNEDY CAPITAL MANAGEMENT LLC | 685,982 | 5,179,000 | 0.77% | ||
| 39 | DIMENSIONAL FUND ADVISORS LP | 591,269 | 4,464,000 | 0.66% | ||
| 40 | J. Goldman & Co LP | 589,200 | 4,448,000 | 0.66% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 537,784 | 4,061,000 | 0.60% | ||
| 42 | Bank of New York Mellon Corp | 490,400 | 3,703,000 | 0.55% | ||
| 43 | WHV Investments, Inc. | 471,148 | 3,557,000 | 0.53% | ||
| 44 | CITADEL ADVISORS LLC | 470,588 | 3,553,000 | 0.53% | ||
| 45 | GEODE CAPITAL MANAGEMENT, LLC | 434,381 | 3,279,000 | 0.49% | ||
| 46 | Ghost Tree Capital, LLC | 300,000 | 2,265,000 | 0.34% | ||
| 47 | MORGAN STANLEY | 291,053 | 2,198,000 | 0.33% | ||
| 48 | Index Management Solutions, LLC | 289,473 | 2,186,000 | 0.32% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 272,739 | 2,059,000 | 0.31% | ||
| 50 | APG Asset Management N.V. | 262,500 | 1,982,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
