| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 8,544,500 | 49,387,000 | 10.75% | ||
| 2 | PFM Health Sciences, LP | 5,884,218 | 34,011,000 | 7.40% | ||
| 3 | VANGUARD GROUP INC | 5,633,705 | 32,563,000 | 7.09% | ||
| 4 | Boston Partners | 4,382,520 | 25,331,000 | 5.51% | ||
| 5 | Neuberger Berman Group LLC | 3,041,371 | 17,579,000 | 3.83% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,853,207 | 16,492,000 | 3.59% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 2,781,400 | 16,076,000 | 3.50% | ||
| 8 | HEARTLAND ADVISORS INC | 2,742,327 | 15,851,000 | 3.45% | ||
| 9 | ORACLE INVESTMENT MANAGEMENT INC | 2,553,218 | 14,758,000 | 3.21% | ||
| 10 | BlackRock Fund Advisors | 2,379,968 | 13,756,000 | 2.99% | ||
| 11 | Elk Creek Partners, LLC | 2,170,258 | 12,544,000 | 2.73% | ||
| 12 | Lapides Asset Management, LLC | 2,142,200 | 12,382,000 | 2.69% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 2,107,667 | 12,182,000 | 2.65% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 2,011,671 | 11,627,000 | 2.53% | ||
| 15 | ROYCE & ASSOCIATES LP | 1,999,500 | 11,557,000 | 2.51% | ||
| 16 | WELLS FARGO & COMPANY/MN | 1,823,665 | 10,541,000 | 2.29% | ||
| 17 | Point72 Asset Management, L.P. | 1,640,800 | 9,484,000 | 2.06% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 1,627,722 | 9,408,000 | 2.05% | ||
| 19 | BLACKROCK ADVISORS LLC | 1,451,597 | 8,390,000 | 1.83% | ||
| 20 | D. E. Shaw & Co., Inc. | 1,424,439 | 8,233,000 | 1.79% | ||
| 21 | KORNITZER CAPITAL MANAGEMENT INC /KS | 1,397,848 | 8,080,000 | 1.76% | ||
| 22 | NORGES BANK | 1,362,339 | 7,874,000 | 1.71% | ||
| 23 | STATE STREET CORP | 1,320,617 | 7,633,000 | 1.66% | ||
| 24 | RK Capital Management, LLC | 1,219,350 | 7,048,000 | 1.53% | ||
| 25 | RUSSELL FRANK CO/ | 1,218,378 | 7,043,000 | 1.53% | ||
| 26 | KENNEDY CAPITAL MANAGEMENT LLC | 1,144,308 | 6,614,000 | 1.44% | ||
| 27 | NORTHERN TRUST CORP | 941,012 | 5,439,000 | 1.18% | ||
| 28 | SECTORAL ASSET MANAGEMENT INC | 771,950 | 4,462,000 | 0.97% | ||
| 29 | PICTET ASSET MANAGEMENT LTD | 879,741 | 4,443,000 | 0.97% | ||
| 30 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 717,099 | 4,145,000 | 0.90% | ||
| 31 | Bank of New York Mellon Corp | 552,737 | 3,195,000 | 0.70% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 551,483 | 3,187,000 | 0.69% | ||
| 33 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 488,378 | 2,822,000 | 0.61% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 478,859 | 2,768,000 | 0.60% | ||
| 35 | VOCE CAPITAL MANAGEMENT LLC | 475,035 | 2,746,000 | 0.60% | ||
| 36 | Granahan Investment Management, LLC | 462,600 | 2,674,000 | 0.58% | ||
| 37 | PURA VIDA INVESTMENTS, LLC | 441,300 | 2,551,000 | 0.56% | ||
| 38 | MORGAN STANLEY | 361,551 | 2,089,000 | 0.45% | ||
| 39 | GOLDMAN SACHS GROUP INC | 297,582 | 1,720,000 | 0.37% | ||
| 40 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 292,200 | 1,689,000 | 0.37% | ||
| 41 | BlackRock Investment Management, LLC | 283,283 | 1,637,000 | 0.36% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 252,022 | 1,457,000 | 0.32% | ||
| 43 | Asset Management One Co., Ltd. | 215,500 | 1,246,000 | 0.27% | ||
| 44 | JACOBS LEVY EQUITY MANAGEMENT, INC | 214,959 | 1,242,000 | 0.27% | ||
| 45 | DIMENSIONAL FUND ADVISORS LP | 211,454 | 1,222,000 | 0.27% | ||
| 46 | PUTNAM INVESTMENTS LLC | 183,337 | 1,059,000 | 0.23% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 167,337 | 967,000 | 0.21% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 160,297 | 927,000 | 0.20% | ||
| 49 | Spark Investment Management LLC | 159,900 | 924,000 | 0.20% | ||
| 50 | WASHINGTON CAPITAL MANAGEMENT, INC | 145,524 | 841,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
