| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,650,018 | 139,650,000 | 12.73% | ||
| 2 | BlackRock Finance, Inc. | 6,425,256 | 134,932,000 | 12.30% | ||
| 3 | SCOPIA CAPITAL MANAGEMENT LP | 5,568,306 | 116,934,000 | 10.66% | ||
| 4 | VANGUARD GROUP INC | 4,139,589 | 86,931,000 | 7.93% | ||
| 5 | BAKER BROS. ADVISORS LP | 3,301,791 | 69,338,000 | 6.32% | ||
| 6 | DIMENSIONAL FUND ADVISORS LP | 1,831,450 | 38,474,000 | 3.51% | ||
| 7 | STATE STREET CORP | 1,624,743 | 34,120,000 | 3.11% | ||
| 8 | Sio Capital Management, LLC | 1,045,400 | 21,953,000 | 2.00% | Put | |
| 9 | Clearbridge Investments, LLC | 945,338 | 19,852,000 | 1.81% | ||
| 10 | CAMBIAR INVESTORS LLC | 835,643 | 17,549,000 | 1.60% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 675,900 | 14,194,000 | 1.29% | Put | |
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 649,800 | 13,646,000 | 1.24% | Call | |
| 13 | Consonance Capital Management LP | 619,419 | 13,008,000 | 1.19% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 590,040 | 12,391,000 | 1.13% | ||
| 15 | Bank of New York Mellon Corp | 582,298 | 12,229,000 | 1.11% | ||
| 16 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 558,885 | 11,737,000 | 1.07% | ||
| 17 | NORTHERN TRUST CORP | 543,670 | 11,417,000 | 1.04% | ||
| 18 | LOOMIS SAYLES & CO L P | 520,803 | 10,937,000 | 1.00% | ||
| 19 | MACQUARIE GROUP LTD | 519,540 | 10,910,000 | 0.99% | ||
| 20 | NORGES BANK | 494,766 | 10,390,000 | 0.95% | ||
| 21 | RA CAPITAL MANAGEMENT, L.P. | 489,828 | 10,286,000 | 0.94% | ||
| 22 | D. E. Shaw & Co., Inc. | 441,624 | 9,274,000 | 0.85% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 440,824 | 9,256,000 | 0.84% | ||
| 24 | GREAT POINT PARTNERS LLC | 432,500 | 9,083,000 | 0.83% | Put | |
| 25 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 426,000 | 8,946,000 | 0.82% | ||
| 26 | Invesco Ltd. | 407,850 | 8,565,000 | 0.78% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 387,668 | 8,142,000 | 0.74% | ||
| 28 | TWO SIGMA ADVISERS, LP | 373,760 | 7,849,000 | 0.72% | ||
| 29 | PRINCIPAL FINANCIAL GROUP INC | 354,029 | 7,435,000 | 0.68% | ||
| 30 | JPMORGAN CHASE & CO | 334,793 | 7,031,000 | 0.64% | ||
| 31 | CITADEL ADVISORS LLC | 323,972 | 6,803,000 | 0.62% | ||
| 32 | GOLDMAN SACHS GROUP INC | 302,689 | 6,356,000 | 0.58% | ||
| 33 | Ghost Tree Capital, LLC | 300,000 | 6,300,000 | 0.57% | ||
| 34 | PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 297,099 | 6,239,000 | 0.57% | ||
| 35 | AMERIPRISE FINANCIAL INC | 286,001 | 6,007,000 | 0.55% | ||
| 36 | STIFEL FINANCIAL CORP | 284,786 | 6,001,000 | 0.55% | ||
| 37 | DLD ASSET MANAGEMENT, LP | 281,900 | 5,920,000 | 0.54% | ||
| 38 | DLD ASSET MANAGEMENT, LP | 281,900 | 5,914,000 | 0.54% | Put | |
| 39 | PRUDENTIAL FINANCIAL INC | 263,785 | 5,540,000 | 0.51% | ||
| 40 | JACOBS LEVY EQUITY MANAGEMENT, INC | 258,186 | 5,422,000 | 0.49% | ||
| 41 | BARCLAYS PLC | 239,300 | 5,025,000 | 0.46% | Put | |
| 42 | MILLENNIUM MANAGEMENT LLC | 212,538 | 4,463,000 | 0.41% | ||
| 43 | DEUTSCHE BANK AG\ | 207,809 | 4,362,000 | 0.40% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 204,672 | 4,298,000 | 0.39% | ||
| 45 | Spark Investment Management LLC | 192,700 | 4,046,000 | 0.37% | ||
| 46 | GOLDMAN SACHS GROUP INC | 171,200 | 3,595,000 | 0.33% | Put | |
| 47 | TWO SIGMA INVESTMENTS, LP | 169,331 | 3,556,000 | 0.32% | ||
| 48 | CREDIT SUISSE AG/ | 158,226 | 3,323,000 | 0.30% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 156,290 | 3,282,000 | 0.30% | ||
| 50 | TIAA CREF INVESTMENT MANAGEMENT LLC | 144,218 | 3,029,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
