| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,899,623 | 55,726,000 | 20.51% | ||
| 2 | RHO CAPITAL PARTNERS INC | 2,668,057 | 38,127,000 | 14.03% | ||
| 3 | SECTORAL ASSET MANAGEMENT INC | 1,023,309 | 14,623,000 | 5.38% | ||
| 4 | BlackRock Fund Advisors | 902,949 | 12,903,000 | 4.75% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 822,400 | 11,752,000 | 4.33% | ||
| 6 | JENNISON ASSOCIATES LLC | 654,458 | 9,352,000 | 3.44% | ||
| 7 | FRANKLIN RESOURCES INC | 611,400 | 8,737,000 | 3.22% | ||
| 8 | CHESAPEAKE PARTNERS MANAGEMENT CO INC/MD | 609,157 | 8,705,000 | 3.20% | ||
| 9 | VANGUARD GROUP INC | 537,667 | 7,684,000 | 2.83% | ||
| 10 | EverPoint Asset Management, LLC | 450,000 | 6,431,000 | 2.37% | ||
| 11 | ALPS ADVISORS INC | 41,616 | 5,947,000 | 2.19% | ||
| 12 | Opaleye Management Inc. | 415,000 | 5,930,000 | 2.18% | ||
| 13 | JPMORGAN CHASE & CO | 387,522 | 5,538,000 | 2.04% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 366,233 | 5,233,000 | 1.93% | ||
| 15 | C WorldWide Group Holding A/S | 338,081 | 4,831,000 | 1.78% | ||
| 16 | WALL STREET ASSOCIATES | 311,000 | 4,444,000 | 1.64% | ||
| 17 | STATE STREET CORP | 260,682 | 3,723,000 | 1.37% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 251,600 | 3,595,000 | 1.32% | ||
| 19 | TIVERTON ASSET MANAGEMENT LLC | 250,000 | 3,573,000 | 1.32% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 219,800 | 3,141,000 | 1.16% | ||
| 21 | NORTHERN TRUST CORP | 201,670 | 2,882,000 | 1.06% | ||
| 22 | Allianz Asset Management GmbH | 190,886 | 2,728,000 | 1.00% | ||
| 23 | Invesco Ltd. | 175,664 | 2,510,000 | 0.92% | ||
| 24 | D. E. Shaw & Co., Inc. | 169,148 | 2,417,000 | 0.89% | ||
| 25 | WELLINGTON MANAGEMENT GROUP LLP | 150,815 | 2,154,000 | 0.79% | ||
| 26 | TEACHERS ADVISORS, LLC | 148,213 | 2,118,000 | 0.78% | ||
| 27 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 142,529 | 2,036,000 | 0.75% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 142,500 | 2,036,000 | 0.75% | ||
| 29 | SHEPHERD KAPLAN KROCHUK, LLC | 114,633 | 1,638,000 | 0.60% | ||
| 30 | SMITH ASSET MANAGEMENT GROUP LP | 114,110 | 1,631,000 | 0.60% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 112,301 | 1,604,000 | 0.59% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,183 | 1,432,000 | 0.53% | ||
| 33 | A.R.T. Advisors, LLC | 96,332 | 1,376,000 | 0.51% | ||
| 34 | DAFNA Capital Management LLC | 93,574 | 1,337,000 | 0.49% | ||
| 35 | BLACKROCK ADVISORS LLC | 87,918 | 1,256,000 | 0.46% | ||
| 36 | DEUTSCHE BANK AG\ | 81,820 | 1,168,000 | 0.43% | ||
| 37 | AQR CAPITAL MANAGEMENT LLC | 76,093 | 1,087,000 | 0.40% | ||
| 38 | PICTET ASSET MANAGEMENT LTD | 75,400 | 1,078,000 | 0.40% | ||
| 39 | MPAM CREDIT TRADING PARTNERS L.P. | 74,938 | 1,071,000 | 0.39% | ||
| 40 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 73,567 | 1,051,000 | 0.39% | ||
| 41 | GSA CAPITAL PARTNERS LLP | 70,319 | 1,005,000 | 0.37% | ||
| 42 | BlackRock Investment Management, LLC | 68,571 | 980,000 | 0.36% | ||
| 43 | TFS CAPITAL LLC | 66,307 | 948,000 | 0.35% | ||
| 44 | Bank of New York Mellon Corp | 65,653 | 938,000 | 0.35% | ||
| 45 | CITADEL ADVISORS LLC | 60,659 | 867,000 | 0.32% | ||
| 46 | Trexquant Investment LP | 57,350 | 819,000 | 0.30% | ||
| 47 | Informed Momentum Co LLC | 55,553 | 794,000 | 0.29% | ||
| 48 | RUSSELL FRANK CO/ | 53,794 | 768,000 | 0.28% | ||
| 49 | BALDWIN WEALTH PARTNERS LLC/MA | 52,029 | 743,000 | 0.27% | ||
| 50 | Alyeska Investment Group, L.P. | 41,278 | 590,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
