| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,876,023 | 65,350,000 | 19.17% | ||
| 2 | RHO CAPITAL PARTNERS INC | 2,668,057 | 44,983,000 | 13.19% | ||
| 3 | SECTORAL ASSET MANAGEMENT INC | 1,212,578 | 20,444,000 | 6.00% | ||
| 4 | EverPoint Asset Management, LLC | 900,000 | 15,174,000 | 4.45% | ||
| 5 | BlackRock Fund Advisors | 853,145 | 14,384,000 | 4.22% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 781,255 | 13,172,000 | 3.86% | ||
| 7 | VANGUARD GROUP INC | 657,030 | 11,077,000 | 3.25% | ||
| 8 | JENNISON ASSOCIATES LLC | 656,467 | 11,068,000 | 3.25% | ||
| 9 | Ridgeback Capital Investments L.P. | 622,140 | 10,489,000 | 3.08% | ||
| 10 | CHESAPEAKE PARTNERS MANAGEMENT CO INC/MD | 618,140 | 10,422,000 | 3.06% | ||
| 11 | FRANKLIN RESOURCES INC | 611,400 | 10,308,000 | 3.02% | ||
| 12 | Point72 Asset Management, L.P. | 530,200 | 8,939,000 | 2.62% | ||
| 13 | Allianz Asset Management GmbH | 443,636 | 7,480,000 | 2.19% | ||
| 14 | Opaleye Management Inc. | 427,000 | 7,199,000 | 2.11% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 421,247 | 7,102,000 | 2.08% | ||
| 16 | JPMORGAN CHASE & CO | 349,610 | 5,894,000 | 1.73% | ||
| 17 | STATE STREET CORP | 282,766 | 4,765,000 | 1.40% | ||
| 18 | C WorldWide Group Holding A/S | 262,000 | 4,417,000 | 1.30% | ||
| 19 | TIVERTON ASSET MANAGEMENT LLC | 250,000 | 4,215,000 | 1.24% | ||
| 20 | Private Capital Advisors, Inc. | 246,850 | 4,162,000 | 1.22% | ||
| 21 | NORTHERN TRUST CORP | 230,879 | 3,893,000 | 1.14% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 197,820 | 3,335,000 | 0.98% | ||
| 23 | WALL STREET ASSOCIATES | 192,300 | 3,242,000 | 0.95% | ||
| 24 | Invesco Ltd. | 184,811 | 3,116,000 | 0.91% | ||
| 25 | DAFNA Capital Management LLC | 169,331 | 2,855,000 | 0.84% | ||
| 26 | TEACHERS ADVISORS, LLC | 152,367 | 2,569,000 | 0.75% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 142,500 | 2,403,000 | 0.70% | ||
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 136,685 | 2,304,000 | 0.68% | ||
| 29 | PICTET ASSET MANAGEMENT LTD | 116,700 | 1,968,000 | 0.58% | ||
| 30 | D. E. Shaw & Co., Inc. | 116,604 | 1,966,000 | 0.58% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 113,954 | 1,921,000 | 0.56% | ||
| 32 | AQR CAPITAL MANAGEMENT LLC | 111,428 | 1,878,000 | 0.55% | ||
| 33 | Informed Momentum Co LLC | 109,599 | 1,848,000 | 0.54% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 102,866 | 1,734,000 | 0.51% | ||
| 35 | Bank of New York Mellon Corp | 97,703 | 1,647,000 | 0.48% | ||
| 36 | CITADEL ADVISORS LLC | 92,021 | 1,551,000 | 0.45% | ||
| 37 | GSA CAPITAL PARTNERS LLP | 91,073 | 1,535,000 | 0.45% | ||
| 38 | BLACKROCK ADVISORS LLC | 85,740 | 1,446,000 | 0.42% | ||
| 39 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 73,567 | 1,240,000 | 0.36% | ||
| 40 | BlackRock Investment Management, LLC | 69,347 | 1,169,000 | 0.34% | ||
| 41 | SHEPHERD KAPLAN KROCHUK, LLC | 63,458 | 1,070,000 | 0.31% | ||
| 42 | BALDWIN WEALTH PARTNERS LLC/MA | 52,029 | 877,000 | 0.26% | ||
| 43 | TFS CAPITAL LLC | 49,708 | 838,000 | 0.25% | ||
| 44 | RENAISSANCE TECHNOLOGIES LLC | 47,540 | 802,000 | 0.24% | ||
| 45 | RUSSELL FRANK CO/ | 50,600 | 799,000 | 0.23% | ||
| 46 | Janney Montgomery Scott LLC | 44,639 | 753,000 | 0.22% | ||
| 47 | Trexquant Investment LP | 43,500 | 733,000 | 0.21% | ||
| 48 | TWO SIGMA INVESTMENTS, LP | 40,055 | 675,000 | 0.20% | ||
| 49 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 37,882 | 638,000 | 0.19% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,820 | 621,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
