| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RHO CAPITAL PARTNERS INC | 3,068,057 | 19,083,000 | 18.77% | ||
| 2 | FMR LLC | 1,592,261 | 9,904,000 | 9.74% | ||
| 3 | SECTORAL ASSET MANAGEMENT INC | 1,212,578 | 7,542,000 | 7.42% | ||
| 4 | CHESAPEAKE PARTNERS MANAGEMENT CO INC/MD | 996,834 | 6,200,000 | 6.10% | ||
| 5 | BlackRock Fund Advisors | 870,309 | 5,413,000 | 5.32% | ||
| 6 | Opaleye Management Inc. | 855,000 | 5,318,000 | 5.23% | ||
| 7 | VANGUARD GROUP INC | 687,439 | 4,276,000 | 4.21% | ||
| 8 | JENNISON ASSOCIATES LLC | 660,691 | 4,109,000 | 4.04% | ||
| 9 | FRANKLIN RESOURCES INC | 611,400 | 3,803,000 | 3.74% | ||
| 10 | JPMORGAN CHASE & CO | 513,382 | 3,194,000 | 3.14% | ||
| 11 | Allianz Asset Management GmbH | 441,618 | 2,747,000 | 2.70% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 416,111 | 2,588,000 | 2.55% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 391,045 | 2,432,000 | 2.39% | ||
| 14 | STATE STREET CORP | 324,157 | 2,018,000 | 1.99% | ||
| 15 | DAFNA Capital Management LLC | 267,046 | 1,661,000 | 1.63% | ||
| 16 | C WorldWide Group Holding A/S | 262,000 | 1,630,000 | 1.60% | ||
| 17 | TIVERTON ASSET MANAGEMENT LLC | 229,639 | 1,429,000 | 1.41% | ||
| 18 | NORTHERN TRUST CORP | 229,293 | 1,426,000 | 1.40% | ||
| 19 | WALL STREET ASSOCIATES | 192,300 | 1,196,000 | 1.18% | ||
| 20 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 142,500 | 886,000 | 0.87% | ||
| 21 | SHEPHERD KAPLAN KROCHUK, LLC | 141,857 | 882,000 | 0.87% | ||
| 22 | A.R.T. Advisors, LLC | 139,303 | 866,000 | 0.85% | ||
| 23 | AQR CAPITAL MANAGEMENT LLC | 125,291 | 779,000 | 0.77% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 116,068 | 721,000 | 0.71% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 102,866 | 640,000 | 0.63% | ||
| 26 | Bank of New York Mellon Corp | 102,992 | 640,000 | 0.63% | ||
| 27 | PICTET ASSET MANAGEMENT LTD | 116,700 | 574,000 | 0.56% | ||
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 89,968 | 559,000 | 0.55% | ||
| 29 | RENAISSANCE TECHNOLOGIES LLC | 89,400 | 556,000 | 0.55% | ||
| 30 | BLACKROCK ADVISORS LLC | 85,644 | 533,000 | 0.52% | ||
| 31 | TUDOR INVESTMENT CORP ET AL | 79,875 | 497,000 | 0.49% | ||
| 32 | BlackRock Investment Management, LLC | 70,406 | 438,000 | 0.43% | ||
| 33 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 58,867 | 366,000 | 0.36% | ||
| 34 | GSA CAPITAL PARTNERS LLP | 56,019 | 348,000 | 0.34% | ||
| 35 | Trexquant Investment LP | 55,676 | 346,000 | 0.34% | ||
| 36 | Numeric Investors LLC | 50,600 | 315,000 | 0.31% | ||
| 37 | Invesco Ltd. | 50,437 | 314,000 | 0.31% | ||
| 38 | Janney Montgomery Scott LLC | 49,128 | 306,000 | 0.30% | ||
| 39 | BALDWIN WEALTH PARTNERS LLC/MA | 48,854 | 304,000 | 0.30% | ||
| 40 | ALAMBIC INVESTMENT MANAGEMENT, L.P. | 48,888 | 304,000 | 0.30% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,729 | 266,000 | 0.26% | ||
| 42 | DEUTSCHE BANK AG\ | 41,625 | 258,000 | 0.25% | ||
| 43 | TEACHERS ADVISORS, LLC | 30,737 | 191,000 | 0.19% | ||
| 44 | ALPS ADVISORS INC | 30,625 | 190,000 | 0.19% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 30,198 | 188,000 | 0.18% | ||
| 46 | Swiss National Bank | 30,100 | 182,000 | 0.18% | ||
| 47 | TFS CAPITAL LLC | 27,708 | 172,000 | 0.17% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,617 | 172,000 | 0.17% | ||
| 49 | D. E. Shaw & Co., Inc. | 24,420 | 152,000 | 0.15% | ||
| 50 | ProShare Advisors LLC | 22,436 | 140,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
