| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 9,515,764 | 144,640,000 | 26.01% | ||
| 2 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 6,568,646 | 99,843,000 | 17.96% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,087,145 | 59,607,000 | 10.72% | ||
| 4 | GILDER GAGNON HOWE & CO LLC | 1,883,338 | 28,627,000 | 5.15% | ||
| 5 | BAILLIE GIFFORD & CO | 1,794,820 | 27,281,000 | 4.91% | ||
| 6 | MORGAN STANLEY | 1,276,549 | 19,403,000 | 3.49% | ||
| 7 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,109,000 | 16,857,000 | 3.03% | ||
| 8 | Redmile Group, LLC | 1,164,257 | 16,463,000 | 2.96% | ||
| 9 | Capital World Investors | 1,079,167 | 16,403,000 | 2.95% | ||
| 10 | LORD, ABBETT & CO. LLC | 888,757 | 13,509,000 | 2.43% | ||
| 11 | BLACKROCK ADVISORS LLC | 788,411 | 11,984,000 | 2.16% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 678,982 | 10,321,000 | 1.86% | ||
| 13 | VANGUARD GROUP INC | 597,903 | 9,088,000 | 1.63% | ||
| 14 | MAVERICK CAPITAL LTD | 450,000 | 6,566,000 | 1.18% | ||
| 15 | BlackRock Fund Advisors | 288,429 | 4,384,000 | 0.79% | ||
| 16 | Capital Research Global Investors | 266,300 | 4,048,000 | 0.73% | ||
| 17 | Artal Group S.A. | 250,000 | 3,800,000 | 0.68% | ||
| 18 | BlackRock Group LTD | 249,897 | 3,798,000 | 0.68% | ||
| 19 | BAMCO INC /NY/ | 246,000 | 3,739,000 | 0.67% | ||
| 20 | GLG LLC | 216,981 | 3,298,000 | 0.59% | ||
| 21 | JPMORGAN CHASE & CO | 193,734 | 2,945,000 | 0.53% | ||
| 22 | Espalier Global Management LLC | 176,573 | 2,684,000 | 0.48% | ||
| 23 | ALLEN OPERATIONS LLC | 157,372 | 2,392,000 | 0.43% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 144,329 | 2,194,000 | 0.39% | ||
| 25 | Alyeska Investment Group, L.P. | 125,663 | 1,910,000 | 0.34% | ||
| 26 | STATE STREET CORP | 118,424 | 1,802,000 | 0.32% | ||
| 27 | TIGER GLOBAL MANAGEMENT LLC | 115,000 | 1,748,000 | 0.31% | ||
| 28 | JENNISON ASSOCIATES LLC | 107,008 | 1,627,000 | 0.29% | ||
| 29 | BlackRock Investment Management, LLC | 105,806 | 1,608,000 | 0.29% | ||
| 30 | D. E. Shaw & Co., Inc. | 105,700 | 1,607,000 | 0.29% | Call | |
| 31 | Artal Group S.A. | 100,000 | 1,520,000 | 0.27% | Call | |
| 32 | Nicholas Investment Partners, LP | 95,787 | 1,456,000 | 0.26% | ||
| 33 | JANUS HENDERSON INVESTORS US LLC | 93,044 | 1,414,000 | 0.25% | ||
| 34 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 91,110 | 1,385,000 | 0.25% | ||
| 35 | Teton Advisors, Inc. | 89,711 | 1,364,000 | 0.25% | ||
| 36 | COLUMBUS CIRCLE INVESTORS | 85,933 | 1,306,000 | 0.23% | ||
| 37 | RAYMOND JAMES & ASSOCIATES | 82,350 | 1,252,000 | 0.23% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,200 | 1,249,000 | 0.22% | Put | |
| 39 | Zweig-DiMenna Associates LLC | 76,500 | 1,163,000 | 0.21% | ||
| 40 | Antipodean Advisors LLC | 76,000 | 1,155,000 | 0.21% | ||
| 41 | Bank of New York Mellon Corp | 66,873 | 1,016,000 | 0.18% | ||
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 66,141 | 1,005,000 | 0.18% | ||
| 43 | D. E. Shaw & Co., Inc. | 62,627 | 952,000 | 0.17% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 58,362 | 887,000 | 0.16% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 53,100 | 807,000 | 0.15% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 50,708 | 771,000 | 0.14% | ||
| 47 | AMERIPRISE FINANCIAL INC | 49,000 | 745,000 | 0.13% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,040 | 700,000 | 0.13% | ||
| 49 | TWO SIGMA INVESTMENTS, LP | 43,601 | 663,000 | 0.12% | ||
| 50 | D. E. Shaw & Co., Inc. | 40,000 | 608,000 | 0.11% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
