| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 9,948,030 | 116,391,000 | 22.43% | ||
| 2 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 6,568,646 | 76,722,000 | 14.79% | ||
| 3 | MORGAN STANLEY | 3,480,619 | 40,723,000 | 7.85% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,368,170 | 39,408,000 | 7.59% | ||
| 5 | BAILLIE GIFFORD & CO | 1,794,820 | 20,999,000 | 4.05% | ||
| 6 | PUTNAM INVESTMENTS LLC | 1,612,426 | 18,865,000 | 3.64% | ||
| 7 | VANGUARD GROUP INC | 1,562,108 | 18,277,000 | 3.52% | ||
| 8 | Capital World Investors | 1,979,167 | 17,575,000 | 3.39% | ||
| 9 | LORD, ABBETT & CO. LLC | 1,256,135 | 14,697,000 | 2.83% | ||
| 10 | Redmile Group, LLC | 1,247,268 | 14,593,000 | 2.81% | ||
| 11 | JENNISON ASSOCIATES LLC | 1,229,053 | 14,380,000 | 2.77% | ||
| 12 | MAVERICK CAPITAL LTD | 1,144,324 | 13,389,000 | 2.58% | ||
| 13 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,071,300 | 12,535,000 | 2.42% | ||
| 14 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,016,119 | 11,888,000 | 2.29% | ||
| 15 | BAMCO INC /NY/ | 828,286 | 9,691,000 | 1.87% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 678,982 | 7,944,000 | 1.53% | ||
| 17 | GAGNON SECURITIES LLC | 483,580 | 5,658,000 | 1.09% | ||
| 18 | GILDER GAGNON HOWE & CO LLC | 472,837 | 5,532,000 | 1.07% | ||
| 19 | CI Global Investments Inc. | 400,000 | 4,680,000 | 0.90% | ||
| 20 | BlackRock Fund Advisors | 339,349 | 3,970,000 | 0.77% | ||
| 21 | Gagnon Advisors, LLC | 331,925 | 3,884,000 | 0.75% | ||
| 22 | D. E. Shaw & Co., Inc. | 309,643 | 3,623,000 | 0.70% | ||
| 23 | JPMORGAN CHASE & CO | 290,463 | 3,398,000 | 0.65% | ||
| 24 | Rock Springs Capital Management LP | 260,200 | 3,044,000 | 0.59% | ||
| 25 | Artal Group S.A. | 250,000 | 2,925,000 | 0.56% | ||
| 26 | GLG LLC | 187,000 | 2,188,000 | 0.42% | ||
| 27 | Alyeska Investment Group, L.P. | 180,442 | 2,111,000 | 0.41% | ||
| 28 | STATE STREET CORP | 170,349 | 1,994,000 | 0.38% | ||
| 29 | ALLEN OPERATIONS LLC | 157,372 | 1,841,000 | 0.35% | ||
| 30 | BlackRock Institutional Trust Company, N.A. | 146,502 | 1,714,000 | 0.33% | ||
| 31 | NORTHERN TRUST CORP | 137,253 | 1,606,000 | 0.31% | ||
| 32 | COLUMBUS CIRCLE INVESTORS | 122,640 | 1,435,000 | 0.28% | ||
| 33 | RAYMOND JAMES & ASSOCIATES | 117,700 | 1,377,000 | 0.27% | ||
| 34 | STONERIDGE INVESTMENT PARTNERS LLC | 116,554 | 1,364,000 | 0.26% | ||
| 35 | TIGER GLOBAL MANAGEMENT LLC | 115,000 | 1,346,000 | 0.26% | ||
| 36 | Teton Advisors, Inc. | 89,924 | 1,052,000 | 0.20% | ||
| 37 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 89,472 | 1,046,822 | 0.20% | ||
| 38 | Weiss Multi-Strategy Advisers LLC | 80,000 | 936,000 | 0.18% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,700 | 862,000 | 0.17% | Call | |
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 69,928 | 818,000 | 0.16% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 66,141 | 773,000 | 0.15% | ||
| 42 | DEUTSCHE BANK AG\ | 61,642 | 721,000 | 0.14% | ||
| 43 | Bank of New York Mellon Corp | 60,415 | 707,000 | 0.14% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 56,550 | 662,000 | 0.13% | ||
| 45 | WESTERLY CAPITAL MANAGEMENT, LLC | 54,000 | 632,000 | 0.12% | ||
| 46 | I.G. INVESTMENT MANAGEMENT, LTD. | 46,534 | 544,000 | 0.10% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 45,038 | 527,000 | 0.10% | ||
| 48 | TD ASSET MANAGEMENT INC | 43,011 | 503,000 | 0.10% | ||
| 49 | Jefferies Group LLC | 40,000 | 468,000 | 0.09% | Call | |
| 50 | FEDERATED HERMES, INC. | 40,000 | 468,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
