| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 6,568,646 | 27,523,000 | 15.36% | ||
| 2 | FMR LLC | 5,945,257 | 24,970,000 | 13.94% | ||
| 3 | MORGAN STANLEY | 3,226,724 | 13,553,000 | 7.57% | ||
| 4 | VANGUARD GROUP INC | 2,157,158 | 9,060,000 | 5.06% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,865,220 | 7,834,000 | 4.37% | ||
| 6 | BAILLIE GIFFORD & CO | 1,794,820 | 7,538,000 | 4.21% | ||
| 7 | PUTNAM INVESTMENTS LLC | 1,685,154 | 7,078,000 | 3.95% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,677,273 | 7,045,000 | 3.93% | ||
| 9 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,177,095 | 4,944,000 | 2.76% | ||
| 10 | MAVERICK CAPITAL LTD | 1,144,324 | 4,806,000 | 2.68% | ||
| 11 | Alyeska Investment Group, L.P. | 1,090,604 | 4,581,000 | 2.56% | ||
| 12 | Rock Springs Capital Management LP | 1,000,000 | 4,200,000 | 2.34% | ||
| 13 | GAGNON SECURITIES LLC | 930,173 | 3,907,000 | 2.18% | ||
| 14 | BlackRock Fund Advisors | 822,016 | 3,452,000 | 1.93% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 783,600 | 3,291,000 | 1.84% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 766,734 | 3,220,000 | 1.80% | ||
| 17 | Redmile Group, LLC | 734,397 | 3,084,000 | 1.72% | ||
| 18 | Gagnon Advisors, LLC | 733,745 | 3,082,000 | 1.72% | ||
| 19 | Endurant Capital Management LP | 718,208 | 3,016,000 | 1.68% | ||
| 20 | GILDER GAGNON HOWE & CO LLC | 638,732 | 2,683,000 | 1.50% | ||
| 21 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 578,982 | 2,432,000 | 1.36% | ||
| 22 | Teton Advisors, Inc. | 416,997 | 1,751,000 | 0.98% | ||
| 23 | STATE STREET CORP | 412,359 | 1,732,000 | 0.97% | ||
| 24 | ROYCE & ASSOCIATES LP | 385,600 | 1,620,000 | 0.90% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 369,910 | 1,554,000 | 0.87% | ||
| 26 | NORTHERN TRUST CORP | 358,308 | 1,505,000 | 0.84% | ||
| 27 | CITADEL ADVISORS LLC | 323,129 | 1,357,000 | 0.76% | ||
| 28 | ArrowMark Colorado Holdings LLC | 298,737 | 1,255,000 | 0.70% | ||
| 29 | STONERIDGE INVESTMENT PARTNERS LLC | 282,402 | 1,186,000 | 0.66% | ||
| 30 | OPPENHEIMER & CO INC | 261,115 | 1,097,000 | 0.61% | ||
| 31 | KORNITZER CAPITAL MANAGEMENT INC /KS | 250,000 | 1,050,000 | 0.59% | ||
| 32 | NEW YORK STATE COMMON RETIREMENT FUND | 209,661 | 881,000 | 0.49% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 194,961 | 818,000 | 0.46% | ||
| 34 | GLG LLC | 188,744 | 793,000 | 0.44% | ||
| 35 | Bank of New York Mellon Corp | 177,800 | 746,000 | 0.42% | ||
| 36 | GOLDMAN SACHS GROUP INC | 176,964 | 743,000 | 0.41% | ||
| 37 | ALLEN OPERATIONS LLC | 157,372 | 661,000 | 0.37% | ||
| 38 | RENAISSANCE TECHNOLOGIES LLC | 128,900 | 541,000 | 0.30% | ||
| 39 | Empire Capital Management, L.L.C. | 125,000 | 525,000 | 0.29% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 118,300 | 497,000 | 0.28% | Call | |
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 118,070 | 496,000 | 0.28% | ||
| 42 | Concourse Capital Management, LLC | 117,650 | 494,000 | 0.28% | ||
| 43 | BlackRock Investment Management, LLC | 115,590 | 485,000 | 0.27% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 104,150 | 437,000 | 0.24% | ||
| 45 | RAYMOND JAMES & ASSOCIATES | 96,700 | 406,000 | 0.23% | ||
| 46 | CONTINENTAL ADVISORS LLC | 93,200 | 391,000 | 0.22% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,932 | 374,000 | 0.21% | ||
| 48 | CREDIT SUISSE AG/ | 68,619 | 288,000 | 0.16% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,400 | 275,000 | 0.15% | Put | |
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,416 | 258,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
