| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 6,568,646 | 53,403,000 | 15.71% | ||
| 2 | FMR LLC | 5,304,380 | 43,178,000 | 12.71% | ||
| 3 | MORGAN STANLEY | 3,258,853 | 26,527,000 | 7.81% | ||
| 4 | PUTNAM INVESTMENTS LLC | 2,710,518 | 22,064,000 | 6.49% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,648,423 | 21,558,000 | 6.34% | ||
| 6 | Redmile Group, LLC | 1,984,631 | 16,155,000 | 4.75% | ||
| 7 | VANGUARD GROUP INC | 1,878,925 | 15,295,000 | 4.50% | ||
| 8 | BAILLIE GIFFORD & CO | 1,794,820 | 14,610,000 | 4.30% | ||
| 9 | GILDER GAGNON HOWE & CO LLC | 1,489,850 | 12,127,000 | 3.57% | ||
| 10 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,275,278 | 10,381,000 | 3.05% | ||
| 11 | MAVERICK CAPITAL LTD | 1,144,324 | 9,315,000 | 2.74% | ||
| 12 | Alyeska Investment Group, L.P. | 875,000 | 7,123,000 | 2.10% | ||
| 13 | GAGNON SECURITIES LLC | 864,527 | 7,037,000 | 2.07% | ||
| 14 | BlackRock Fund Advisors | 809,689 | 6,591,000 | 1.94% | ||
| 15 | Rock Springs Capital Management LP | 800,000 | 6,512,000 | 1.92% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 578,982 | 4,713,000 | 1.39% | ||
| 17 | Gagnon Advisors, LLC | 557,822 | 4,541,000 | 1.34% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 550,600 | 4,482,000 | 1.32% | ||
| 19 | JPMORGAN CHASE & CO | 427,640 | 3,480,000 | 1.02% | ||
| 20 | ROYCE & ASSOCIATES LP | 360,600 | 2,935,000 | 0.86% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 346,015 | 2,817,000 | 0.83% | ||
| 22 | STATE STREET CORP | 328,425 | 2,675,000 | 0.79% | ||
| 23 | Endurant Capital Management LP | 326,223 | 2,655,000 | 0.78% | ||
| 24 | ArrowMark Colorado Holdings LLC | 272,341 | 2,217,000 | 0.65% | ||
| 25 | OPPENHEIMER & CO INC | 261,715 | 2,130,000 | 0.63% | ||
| 26 | Artal Group S.A. | 250,000 | 2,035,000 | 0.60% | ||
| 27 | Teton Advisors, Inc. | 239,263 | 1,948,000 | 0.57% | ||
| 28 | GLG LLC | 210,125 | 1,710,000 | 0.50% | ||
| 29 | STONERIDGE INVESTMENT PARTNERS LLC | 190,923 | 1,554,000 | 0.46% | ||
| 30 | D. E. Shaw & Co., Inc. | 185,003 | 1,506,000 | 0.44% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 183,400 | 1,493,000 | 0.44% | Call | |
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 174,000 | 1,416,000 | 0.42% | Put | |
| 33 | RAYMOND JAMES & ASSOCIATES | 171,350 | 1,395,000 | 0.41% | ||
| 34 | ALLEN OPERATIONS LLC | 157,372 | 1,281,000 | 0.38% | ||
| 35 | NORTHERN TRUST CORP | 156,179 | 1,271,000 | 0.37% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 150,905 | 1,228,000 | 0.36% | ||
| 37 | RENAISSANCE TECHNOLOGIES LLC | 137,500 | 1,119,000 | 0.33% | ||
| 38 | Bank of New York Mellon Corp | 129,132 | 1,051,000 | 0.31% | ||
| 39 | Iguana Healthcare Management, LLC | 120,000 | 977,000 | 0.29% | ||
| 40 | BlackRock Investment Management, LLC | 112,573 | 916,000 | 0.27% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 98,284 | 800,000 | 0.24% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 96,848 | 788,000 | 0.23% | ||
| 43 | CREDIT SUISSE AG/ | 92,346 | 752,000 | 0.22% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 87,850 | 715,000 | 0.21% | ||
| 45 | CONTINENTAL ADVISORS LLC | 78,200 | 637,000 | 0.19% | ||
| 46 | Empire Capital Management, L.L.C. | 75,000 | 611,000 | 0.18% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 74,723 | 608,000 | 0.18% | ||
| 48 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 69,612 | 567,000 | 0.17% | ||
| 49 | MILLENNIUM MANAGEMENT LLC | 67,025 | 546,000 | 0.16% | ||
| 50 | COLUMBUS CIRCLE INVESTORS | 61,811 | 503,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
