| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,353,330 | 80,342,000 | 23.17% | ||
| 2 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 6,568,646 | 50,973,000 | 14.70% | ||
| 3 | MORGAN STANLEY | 3,145,014 | 24,405,000 | 7.04% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,648,423 | 20,552,000 | 5.93% | ||
| 5 | Redmile Group, LLC | 2,336,498 | 18,131,000 | 5.23% | ||
| 6 | Capital World Investors | 1,969,767 | 15,285,000 | 4.41% | ||
| 7 | BAILLIE GIFFORD & CO | 1,794,820 | 13,928,000 | 4.02% | ||
| 8 | PUTNAM INVESTMENTS LLC | 1,779,002 | 13,805,000 | 3.98% | ||
| 9 | VANGUARD GROUP INC | 1,660,886 | 12,888,000 | 3.72% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 1,355,789 | 10,521,000 | 3.03% | ||
| 11 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,251,390 | 9,711,000 | 2.80% | ||
| 12 | MAVERICK CAPITAL LTD | 1,144,324 | 8,880,000 | 2.56% | ||
| 13 | GAGNON SECURITIES LLC | 736,257 | 5,713,000 | 1.65% | ||
| 14 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 603,797 | 4,685,000 | 1.35% | ||
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 578,982 | 4,493,000 | 1.30% | ||
| 16 | Rock Springs Capital Management LP | 525,000 | 4,074,000 | 1.17% | ||
| 17 | Gagnon Advisors, LLC | 507,111 | 3,935,000 | 1.13% | ||
| 18 | JPMORGAN CHASE & CO | 391,155 | 3,036,000 | 0.88% | ||
| 19 | BlackRock Fund Advisors | 342,876 | 2,661,000 | 0.77% | ||
| 20 | BlueCrest Capital Management Ltd | 300,000 | 2,328,000 | 0.67% | ||
| 21 | Endurant Capital Management LP | 259,300 | 2,012,000 | 0.58% | ||
| 22 | STONERIDGE INVESTMENT PARTNERS LLC | 252,489 | 1,959,000 | 0.56% | ||
| 23 | Artal Group S.A. | 250,000 | 1,940,000 | 0.56% | ||
| 24 | Teton Advisors, Inc. | 239,278 | 1,857,000 | 0.54% | ||
| 25 | NEW YORK STATE COMMON RETIREMENT FUND | 225,804 | 1,752,000 | 0.51% | ||
| 26 | SABBY MANAGEMENT, LLC | 217,600 | 1,689,000 | 0.49% | ||
| 27 | GLG LLC | 213,607 | 1,658,000 | 0.48% | ||
| 28 | BlackRock Institutional Trust Company, N.A. | 205,644 | 1,596,000 | 0.46% | ||
| 29 | ArrowMark Colorado Holdings LLC | 200,835 | 1,558,000 | 0.45% | ||
| 30 | Iguana Healthcare Management, LLC | 200,000 | 1,552,000 | 0.45% | ||
| 31 | Alyeska Investment Group, L.P. | 193,102 | 1,498,000 | 0.43% | ||
| 32 | STATE STREET CORP | 185,695 | 1,438,000 | 0.41% | ||
| 33 | ALLEN OPERATIONS LLC | 157,372 | 1,221,000 | 0.35% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157,000 | 1,218,000 | 0.35% | Call | |
| 35 | ROYCE & ASSOCIATES LP | 153,400 | 1,190,000 | 0.34% | ||
| 36 | GOLDMAN SACHS GROUP INC | 152,600 | 1,184,000 | 0.34% | Call | |
| 37 | NORTHERN TRUST CORP | 136,315 | 1,058,000 | 0.31% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 108,658 | 843,000 | 0.24% | ||
| 39 | RAYMOND JAMES & ASSOCIATES | 101,050 | 784,000 | 0.23% | ||
| 40 | Bank of New York Mellon Corp | 72,394 | 562,000 | 0.16% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 68,550 | 532,000 | 0.15% | ||
| 42 | CONTINENTAL ADVISORS LLC | 68,200 | 529,000 | 0.15% | ||
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 67,278 | 522,000 | 0.15% | ||
| 44 | FEDERATED HERMES, INC. | 60,000 | 466,000 | 0.13% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,160 | 428,000 | 0.12% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 42,400 | 385,000 | 0.11% | ||
| 47 | GOLDMAN SACHS GROUP INC | 44,804 | 348,000 | 0.10% | ||
| 48 | Swiss National Bank | 40,700 | 316,000 | 0.09% | ||
| 49 | UBS Group AG | 38,760 | 301,000 | 0.09% | ||
| 50 | BlackRock Investment Management, LLC | 37,971 | 295,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
