| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 13,584,600 | 130,412,000 | 11.02% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 11,129,830 | 106,846,000 | 9.03% | ||
| 3 | FMR LLC | 11,044,370 | 106,026,000 | 8.96% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 9,982,578 | 95,833,000 | 8.10% | ||
| 5 | BAKER BROS. ADVISORS LP | 5,681,237 | 54,540,000 | 4.61% | ||
| 6 | BlackRock Fund Advisors | 4,605,886 | 44,217,000 | 3.74% | ||
| 7 | VANGUARD GROUP INC | 4,186,154 | 40,187,000 | 3.40% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 3,940,485 | 37,829,000 | 3.20% | ||
| 9 | STATE STREET CORP | 3,868,146 | 37,135,000 | 3.14% | ||
| 10 | JANUS HENDERSON INVESTORS US LLC | 3,783,506 | 36,322,000 | 3.07% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,717,013 | 35,683,000 | 3.01% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 3,179,562 | 30,524,000 | 2.58% | ||
| 13 | D. E. Shaw & Co., Inc. | 3,114,939 | 29,903,000 | 2.53% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 2,710,598 | 26,022,000 | 2.20% | ||
| 15 | QVT Financial LP | 2,193,600 | 21,059,000 | 1.78% | ||
| 16 | VHCP Management, LLC | 2,000,859 | 19,208,000 | 1.62% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,973,500 | 18,946,000 | 1.60% | ||
| 18 | Cormorant Asset Management, LP | 1,800,000 | 17,280,000 | 1.46% | ||
| 19 | CITADEL ADVISORS LLC | 1,639,858 | 15,743,000 | 1.33% | ||
| 20 | NORTHERN TRUST CORP | 1,567,848 | 15,052,000 | 1.27% | ||
| 21 | WELLINGTON MANAGEMENT GROUP LLP | 1,366,734 | 13,121,000 | 1.11% | ||
| 22 | EVENTIDE ASSET MANAGEMENT, LLC | 1,330,400 | 12,772,000 | 1.08% | ||
| 23 | FRANKLIN RESOURCES INC | 1,301,600 | 12,495,000 | 1.06% | ||
| 24 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,275,000 | 12,240,000 | 1.03% | ||
| 25 | BLACKROCK ADVISORS LLC | 1,186,916 | 11,394,000 | 0.96% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,104,732 | 10,606,000 | 0.90% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 830,939 | 7,977,000 | 0.67% | ||
| 28 | Bank of New York Mellon Corp | 829,664 | 7,965,000 | 0.67% | ||
| 29 | BNP Paribas Asset Management Holding S.A. | 785,800 | 7,544,000 | 0.64% | ||
| 30 | TWO SIGMA ADVISERS, LP | 767,338 | 7,366,000 | 0.62% | ||
| 31 | Cupps Capital Management, LLC | 732,672 | 7,033,000 | 0.59% | ||
| 32 | MORGAN STANLEY | 657,125 | 6,309,000 | 0.53% | ||
| 33 | SPHERA FUNDS MANAGEMENT LTD. | 650,000 | 6,240,000 | 0.53% | ||
| 34 | MACQUARIE GROUP LTD | 650,000 | 6,240,000 | 0.53% | ||
| 35 | AXA S.A. | 627,279 | 6,022,000 | 0.51% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 593,945 | 5,702,000 | 0.48% | ||
| 37 | BROWN ADVISORY INC | 551,025 | 5,289,000 | 0.45% | ||
| 38 | PANAGORA ASSET MANAGEMENT INC | 526,141 | 5,051,000 | 0.43% | ||
| 39 | GOLDMAN SACHS GROUP INC | 514,804 | 4,942,000 | 0.42% | ||
| 40 | PointState Capital LP | 500,000 | 4,800,000 | 0.41% | ||
| 41 | RENAISSANCE TECHNOLOGIES LLC | 469,186 | 4,504,000 | 0.38% | ||
| 42 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 459,685 | 4,413,000 | 0.37% | ||
| 43 | BlackRock Investment Management, LLC | 423,134 | 4,062,000 | 0.34% | ||
| 44 | DRIEHAUS CAPITAL MANAGEMENT LLC | 409,704 | 3,933,000 | 0.33% | ||
| 45 | HBK INVESTMENTS L P | 401,036 | 3,850,000 | 0.33% | ||
| 46 | DIMENSIONAL FUND ADVISORS LP | 398,297 | 3,824,000 | 0.32% | ||
| 47 | ROYCE & ASSOCIATES LP | 380,200 | 3,650,000 | 0.31% | ||
| 48 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 372,236 | 3,574,000 | 0.30% | ||
| 49 | DEUTSCHE BANK AG\ | 350,377 | 3,361,000 | 0.28% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 342,416 | 3,287,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
