| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 14,643,737 | 131,500,000 | 11.90% | ||
| 2 | FMR LLC | 12,262,143 | 110,114,000 | 9.97% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 11,806,990 | 106,027,000 | 9.60% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 7,436,470 | 66,780,000 | 6.04% | ||
| 5 | BlackRock Fund Advisors | 5,235,703 | 47,017,000 | 4.26% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 4,557,310 | 40,925,000 | 3.70% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 4,249,068 | 38,157,000 | 3.45% | ||
| 8 | VANGUARD GROUP INC | 4,095,573 | 36,778,000 | 3.33% | ||
| 9 | STATE STREET CORP | 4,062,057 | 36,477,000 | 3.30% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,786,478 | 34,003,000 | 3.08% | ||
| 11 | D. E. Shaw & Co., Inc. | 3,048,121 | 27,372,000 | 2.48% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 2,562,674 | 23,013,000 | 2.08% | ||
| 13 | BAKER BROS. ADVISORS LP | 2,531,766 | 22,735,000 | 2.06% | ||
| 14 | CITADEL ADVISORS LLC | 2,450,725 | 22,008,000 | 1.99% | ||
| 15 | QVT Financial LP | 2,309,000 | 20,735,000 | 1.88% | ||
| 16 | JANUS HENDERSON INVESTORS US LLC | 2,132,595 | 19,151,000 | 1.73% | ||
| 17 | VHCP Management, LLC | 2,000,859 | 17,968,000 | 1.63% | ||
| 18 | Cormorant Asset Management, LP | 2,000,000 | 17,960,000 | 1.63% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,988,100 | 17,853,000 | 1.62% | ||
| 20 | Invesco Ltd. | 1,684,668 | 15,128,000 | 1.37% | ||
| 21 | NORTHERN TRUST CORP | 1,626,591 | 14,606,000 | 1.32% | ||
| 22 | WELLINGTON MANAGEMENT GROUP LLP | 1,425,937 | 12,805,000 | 1.16% | ||
| 23 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,400,000 | 12,572,000 | 1.14% | ||
| 24 | FRANKLIN RESOURCES INC | 1,301,600 | 11,688,000 | 1.06% | ||
| 25 | EVENTIDE ASSET MANAGEMENT, LLC | 1,278,000 | 11,476,000 | 1.04% | ||
| 26 | BLACKROCK ADVISORS LLC | 1,102,153 | 9,898,000 | 0.90% | ||
| 27 | SAC Capital Advisors LP | 960,155 | 8,622,000 | 0.78% | ||
| 28 | TWO SIGMA ADVISERS, LP | 943,138 | 8,469,000 | 0.77% | ||
| 29 | DIMENSIONAL FUND ADVISORS LP | 836,063 | 7,508,000 | 0.68% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 818,654 | 7,351,000 | 0.67% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 790,250 | 7,097,000 | 0.64% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 742,804 | 6,670,000 | 0.60% | ||
| 33 | TWO SIGMA INVESTMENTS, LP | 737,424 | 6,622,000 | 0.60% | ||
| 34 | Bank of New York Mellon Corp | 689,542 | 6,191,000 | 0.56% | ||
| 35 | AXA S.A. | 652,512 | 5,860,000 | 0.53% | ||
| 36 | Tourbillon Capital Partners, L.P. | 600,000 | 5,388,000 | 0.49% | ||
| 37 | GOLDMAN SACHS GROUP INC | 591,705 | 5,313,000 | 0.48% | ||
| 38 | MACQUARIE GROUP LTD | 574,000 | 5,155,000 | 0.47% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 568,414 | 5,104,000 | 0.46% | ||
| 40 | DEUTSCHE BANK AG\ | 540,096 | 4,849,000 | 0.44% | ||
| 41 | RA CAPITAL MANAGEMENT, L.P. | 500,000 | 4,490,000 | 0.41% | Call | |
| 42 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 495,785 | 4,453,000 | 0.40% | ||
| 43 | ROYCE & ASSOCIATES LP | 485,600 | 4,361,000 | 0.39% | ||
| 44 | Cupps Capital Management, LLC | 451,774 | 4,056,000 | 0.37% | ||
| 45 | PANAGORA ASSET MANAGEMENT INC | 441,722 | 3,966,000 | 0.36% | ||
| 46 | BlackRock Investment Management, LLC | 370,854 | 3,330,000 | 0.30% | ||
| 47 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 282,386 | 2,536,000 | 0.23% | ||
| 48 | AQR CAPITAL MANAGEMENT LLC | 252,428 | 2,267,000 | 0.21% | ||
| 49 | BlackRock Group LTD | 245,141 | 2,202,000 | 0.20% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 244,702 | 2,197,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
