| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,922,779 | 233,276,000 | 10.45% | ||
| 2 | FEDERATED HERMES, INC. | 11,756,600 | 196,982,000 | 8.83% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 10,632,860 | 178,100,000 | 7.98% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 10,205,683 | 170,996,000 | 7.66% | ||
| 5 | VANGUARD GROUP INC | 8,497,037 | 142,366,000 | 6.38% | ||
| 6 | BAKER BROS. ADVISORS LP | 6,021,485 | 100,890,000 | 4.52% | ||
| 7 | BlackRock Fund Advisors | 5,205,344 | 87,216,000 | 3.91% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,273,126 | 71,596,000 | 3.21% | ||
| 9 | RA CAPITAL MANAGEMENT, L.P. | 4,207,594 | 70,498,000 | 3.16% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,864,266 | 64,746,000 | 2.90% | ||
| 11 | STATE STREET CORP | 3,570,335 | 59,820,000 | 2.68% | ||
| 12 | D. E. Shaw & Co., Inc. | 3,301,301 | 55,313,000 | 2.48% | ||
| 13 | JENNISON ASSOCIATES LLC | 2,279,119 | 38,187,000 | 1.71% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 2,231,617 | 37,391,000 | 1.68% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 1,777,000 | 29,774,000 | 1.33% | ||
| 16 | Invesco Ltd. | 1,671,270 | 28,002,000 | 1.25% | ||
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 1,604,035 | 26,876,000 | 1.20% | ||
| 18 | RTW INVESTMENTS, LP | 1,585,098 | 26,558,000 | 1.19% | ||
| 19 | NORTHERN TRUST CORP | 1,534,969 | 25,718,000 | 1.15% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 1,330,400 | 22,291,000 | 1.00% | ||
| 21 | NORGES BANK | 1,245,484 | 20,868,000 | 0.94% | ||
| 22 | BLACKROCK ADVISORS LLC | 1,157,143 | 19,388,000 | 0.87% | ||
| 23 | Cormorant Asset Management, LP | 1,138,900 | 19,082,000 | 0.85% | ||
| 24 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,131,414 | 18,957,000 | 0.85% | ||
| 25 | CITADEL ADVISORS LLC | 1,044,856 | 17,507,000 | 0.78% | ||
| 26 | VHCP Management, LLC | 1,000,659 | 16,766,000 | 0.75% | ||
| 27 | Asset Management One Co., Ltd. | 879,113 | 14,988,000 | 0.67% | ||
| 28 | VOYA INVESTMENT MANAGEMENT LLC | 879,333 | 14,733,000 | 0.66% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 864,271 | 14,480,000 | 0.65% | ||
| 30 | Bank of New York Mellon Corp | 842,981 | 14,125,000 | 0.63% | ||
| 31 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 800,000 | 13,404,000 | 0.60% | ||
| 32 | FRANKLIN RESOURCES INC | 777,500 | 13,027,000 | 0.58% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 760,340 | 12,740,000 | 0.57% | ||
| 34 | Visium Asset Management, LP | 748,934 | 12,548,000 | 0.56% | ||
| 35 | PRUDENTIAL FINANCIAL INC | 738,584 | 12,375,000 | 0.55% | ||
| 36 | BROWN ADVISORY INC | 720,388 | 12,070,000 | 0.54% | ||
| 37 | MACQUARIE GROUP LTD | 650,000 | 10,891,000 | 0.49% | ||
| 38 | TWO SIGMA ADVISERS, LP | 642,838 | 10,771,000 | 0.48% | ||
| 39 | QVT Financial LP | 597,866 | 10,017,000 | 0.45% | ||
| 40 | AXA S.A. | 573,783 | 9,614,000 | 0.43% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 543,357 | 9,104,000 | 0.41% | ||
| 42 | GOLDMAN SACHS GROUP INC | 527,886 | 8,845,000 | 0.40% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 499,100 | 8,362,000 | 0.37% | Put | |
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 493,200 | 8,264,000 | 0.37% | Call | |
| 45 | HealthCor Management, L.P. | 489,900 | 8,208,000 | 0.37% | ||
| 46 | PANAGORA ASSET MANAGEMENT INC | 462,014 | 7,741,000 | 0.35% | ||
| 47 | BNP Paribas Asset Management Holding S.A. | 452,509 | 7,582,000 | 0.34% | ||
| 48 | BlackRock Investment Management, LLC | 422,413 | 7,078,000 | 0.32% | ||
| 49 | MORGAN STANLEY | 416,069 | 6,970,000 | 0.31% | ||
| 50 | PERCEPTIVE ADVISORS LLC | 400,000 | 6,702,000 | 0.30% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
