| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 13,584,600 | 137,476,000 | 10.60% | ||
| 2 | FMR LLC | 12,462,343 | 126,119,000 | 9.72% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 10,884,960 | 110,156,000 | 8.49% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 8,479,934 | 85,817,000 | 6.61% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 7,809,139 | 79,028,000 | 6.09% | ||
| 6 | BAKER BROS. ADVISORS LP | 6,157,789 | 62,317,000 | 4.80% | ||
| 7 | BlackRock Fund Advisors | 4,581,056 | 46,360,000 | 3.57% | ||
| 8 | VANGUARD GROUP INC | 4,325,863 | 43,778,000 | 3.37% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,791,132 | 38,366,000 | 2.96% | ||
| 10 | STATE STREET CORP | 3,639,665 | 36,831,000 | 2.84% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 3,263,401 | 33,026,000 | 2.55% | ||
| 12 | D. E. Shaw & Co., Inc. | 3,063,628 | 31,004,000 | 2.39% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,954,684 | 29,901,000 | 2.30% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 2,835,498 | 28,695,000 | 2.21% | ||
| 15 | JENNISON ASSOCIATES LLC | 2,010,562 | 20,347,000 | 1.57% | ||
| 16 | VHCP Management, LLC | 2,000,859 | 20,249,000 | 1.56% | ||
| 17 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,975,000 | 19,987,000 | 1.54% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,964,900 | 19,885,000 | 1.53% | ||
| 19 | QVT Financial LP | 1,656,300 | 16,762,000 | 1.29% | ||
| 20 | NORTHERN TRUST CORP | 1,573,126 | 15,920,000 | 1.23% | ||
| 21 | Cormorant Asset Management, LP | 1,500,000 | 15,180,000 | 1.17% | ||
| 22 | WELLINGTON MANAGEMENT GROUP LLP | 1,371,734 | 13,882,000 | 1.07% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 1,330,400 | 13,464,000 | 1.04% | ||
| 24 | BLACKROCK ADVISORS LLC | 1,154,213 | 11,680,000 | 0.90% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,112,612 | 11,260,000 | 0.87% | ||
| 26 | FRANKLIN RESOURCES INC | 1,033,600 | 10,460,000 | 0.81% | ||
| 27 | Bank of New York Mellon Corp | 872,703 | 8,831,000 | 0.68% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 834,941 | 8,449,000 | 0.65% | ||
| 29 | BNP Paribas Asset Management Holding S.A. | 834,390 | 8,444,000 | 0.65% | ||
| 30 | TWO SIGMA ADVISERS, LP | 802,938 | 8,126,000 | 0.63% | ||
| 31 | TEACHERS ADVISORS, LLC | 800,993 | 8,106,000 | 0.62% | ||
| 32 | BROWN ADVISORY INC | 793,084 | 8,025,000 | 0.62% | ||
| 33 | Cupps Capital Management, LLC | 787,827 | 7,972,000 | 0.61% | ||
| 34 | MACQUARIE GROUP LTD | 650,000 | 6,578,000 | 0.51% | ||
| 35 | AXA S.A. | 623,277 | 6,308,000 | 0.49% | ||
| 36 | MORGAN STANLEY | 621,999 | 6,295,000 | 0.49% | ||
| 37 | Asset Management One Co., Ltd. | 585,940 | 6,158,000 | 0.47% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 580,707 | 5,877,000 | 0.45% | ||
| 39 | TFS CAPITAL LLC | 552,812 | 5,594,000 | 0.43% | ||
| 40 | CITADEL ADVISORS LLC | 546,256 | 5,529,000 | 0.43% | ||
| 41 | GOLDMAN SACHS GROUP INC | 535,119 | 5,416,000 | 0.42% | ||
| 42 | SPHERA FUNDS MANAGEMENT LTD. | 517,556 | 5,238,000 | 0.40% | ||
| 43 | PANAGORA ASSET MANAGEMENT INC | 511,730 | 5,179,000 | 0.40% | ||
| 44 | DEUTSCHE BANK AG\ | 500,950 | 5,068,000 | 0.39% | ||
| 45 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 428,396 | 4,335,000 | 0.33% | ||
| 46 | BlackRock Investment Management, LLC | 423,252 | 4,283,000 | 0.33% | ||
| 47 | EverPoint Asset Management, LLC | 375,000 | 3,795,000 | 0.29% | ||
| 48 | TWO SIGMA INVESTMENTS, LP | 371,999 | 3,765,000 | 0.29% | ||
| 49 | DRIEHAUS CAPITAL MANAGEMENT LLC | 370,460 | 3,749,000 | 0.29% | ||
| 50 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 340,476 | 3,446,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
