| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 21,851,074 | 579,053,000 | 15.83% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 10,617,860 | 281,373,000 | 7.69% | ||
| 3 | VANGUARD GROUP INC | 9,733,648 | 257,941,000 | 7.05% | ||
| 4 | FEDERATED HERMES, INC. | 9,391,600 | 248,877,000 | 6.81% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 8,534,772 | 226,171,000 | 6.18% | ||
| 6 | BAKER BROS. ADVISORS LP | 7,926,630 | 210,056,000 | 5.74% | ||
| 7 | BlackRock Fund Advisors | 5,390,809 | 142,856,000 | 3.91% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,612,666 | 122,236,000 | 3.34% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,750,897 | 99,399,000 | 2.72% | ||
| 10 | D. E. Shaw & Co., Inc. | 3,408,353 | 90,321,000 | 2.47% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 2,786,060 | 73,831,000 | 2.02% | ||
| 12 | RA CAPITAL MANAGEMENT, L.P. | 2,703,093 | 71,632,000 | 1.96% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,483,507 | 65,813,000 | 1.80% | ||
| 14 | JENNISON ASSOCIATES LLC | 2,294,365 | 60,801,000 | 1.66% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 1,786,315 | 47,337,000 | 1.29% | ||
| 16 | NORTHERN TRUST CORP | 1,616,334 | 42,833,000 | 1.17% | ||
| 17 | Cormorant Asset Management, LP | 1,400,000 | 37,100,000 | 1.01% | ||
| 18 | LORD, ABBETT & CO. LLC | 1,333,683 | 35,343,000 | 0.97% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 1,330,400 | 35,256,000 | 0.96% | ||
| 20 | NORGES BANK | 1,324,411 | 35,097,000 | 0.96% | ||
| 21 | WELLINGTON MANAGEMENT GROUP LLP | 1,314,620 | 34,837,000 | 0.95% | ||
| 22 | Invesco Ltd. | 1,252,628 | 33,195,000 | 0.91% | ||
| 23 | BLACKROCK ADVISORS LLC | 1,238,686 | 32,825,000 | 0.90% | ||
| 24 | ORBIMED ADVISORS LLC | 1,117,000 | 29,601,000 | 0.81% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 976,194 | 25,869,000 | 0.71% | ||
| 26 | AMERIPRISE FINANCIAL INC | 897,237 | 23,777,000 | 0.65% | ||
| 27 | Bank of New York Mellon Corp | 872,700 | 23,126,000 | 0.63% | ||
| 28 | FRANKLIN RESOURCES INC | 777,500 | 20,604,000 | 0.56% | ||
| 29 | VOYA INVESTMENT MANAGEMENT LLC | 741,159 | 19,641,000 | 0.54% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 730,210 | 19,351,000 | 0.53% | ||
| 31 | GOLDMAN SACHS GROUP INC | 659,471 | 17,476,000 | 0.48% | ||
| 32 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 650,000 | 17,225,000 | 0.47% | ||
| 33 | TWO SIGMA ADVISERS, LP | 643,438 | 17,051,000 | 0.47% | ||
| 34 | CITADEL ADVISORS LLC | 632,613 | 16,764,000 | 0.46% | ||
| 35 | BROWN ADVISORY INC | 620,145 | 16,434,000 | 0.45% | ||
| 36 | ArrowMark Colorado Holdings LLC | 606,972 | 16,085,000 | 0.44% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 599,585 | 15,889,000 | 0.43% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 589,647 | 15,626,000 | 0.43% | ||
| 39 | RTW INVESTMENTS, LP | 559,141 | 14,817,000 | 0.41% | ||
| 40 | BlackRock Investment Management, LLC | 554,207 | 14,686,000 | 0.40% | ||
| 41 | PANAGORA ASSET MANAGEMENT INC | 537,383 | 14,241,000 | 0.39% | ||
| 42 | Asset Management One Co., Ltd. | 539,293 | 13,962,000 | 0.38% | ||
| 43 | BRIDGER MANAGEMENT, LLC | 523,157 | 13,864,000 | 0.38% | ||
| 44 | GREAT POINT PARTNERS LLC | 472,739 | 12,528,000 | 0.34% | ||
| 45 | SENZAR ASSET MANAGEMENT, LLC | 440,433 | 11,671,000 | 0.32% | ||
| 46 | Visium Asset Management, LP | 417,567 | 11,066,000 | 0.30% | ||
| 47 | AXA S.A. | 417,330 | 11,059,000 | 0.30% | ||
| 48 | Allianz Asset Management GmbH | 400,010 | 10,601,000 | 0.29% | ||
| 49 | MACQUARIE GROUP LTD | 400,000 | 10,600,000 | 0.29% | ||
| 50 | RUSSELL FRANK CO/ | 390,281 | 10,342,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
